Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study (original) (raw)

Abstract

Purpose

Diet after prostate cancer diagnosis may impact disease progression. We hypothesized that consuming saturated fat after prostate cancer diagnosis would increase risk of mortality, and consuming vegetable fat after diagnosis would lower the risk of mortality.

Methods

This was a prospective study among 926 men with non-metastatic prostate cancer in the Physicians’ Health Study who completed a food frequency questionnaire a median of 5 years after diagnosis and were followed for a median of 10 years after the questionnaire. We examined post-diagnostic saturated, monounsaturated, polyunsaturated, and trans fat, as well as animal and vegetable fat, intake in relation to all-cause and prostate cancer-specific mortality. Hazard ratios (HR) and 95 % confidence intervals (CI) were estimated using multivariate Cox proportional hazards regression.

Results

We observed 333 deaths (56 prostate cancer deaths) during follow-up. Men who obtained 5 % more of their daily calories from saturated fat and 5 % less of their daily calories from carbohydrate after diagnosis had a 1.8-fold increased risk of all-cause mortality (HR 1.81; 95 % CI 1.20, 2.74; p value 0.005) and a 2.8-fold increased risk of prostate cancer-specific mortality (HR 2.78; 95 % CI 1.01, 7.64; p value 0.05). Men who obtained 10 % more of their daily calories from vegetable fats and 10 % less of their daily calories from carbohydrates had a 33 % lower risk of all-cause mortality (HR 0.67; 95 % CI 0.47, 0.96; p value 0.03).

Conclusions

Among men with non-metastatic prostate cancer, saturated fat intake may increase risk of death and vegetable fat intake may lower risk of death.

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Acknowledgments

This work was supported by grants from the United States Department of Defense (W81XWH-11-1-0529), the National Institutes of Health (CA42182, CA58684, CA90598, CA141298, HL35464, CA167552, CA34944, CA40360, HL26490, HL34595), and the Prostate Cancer Foundation.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, University of California, Mission Hall: Global Health and Clinical Sciences Building, 550 16th St. 2nd Flr., UCSF Box 0560, San Francisco, CA, 94158, USA
    Erin L. Van Blarigan & June M. Chan
  2. Department of Urology, University of California, San Francisco, CA, USA
    Erin L. Van Blarigan, Stacey A. Kenfield & June M. Chan
  3. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Meng Yang, Meir J. Stampfer & Jorge E. Chavarro
  4. Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
    Howard D. Sesso & Meir J. Stampfer
  5. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
    Jing Ma, Meir J. Stampfer & Jorge E. Chavarro
  6. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Jing Ma, Meir J. Stampfer & Jorge E. Chavarro

Authors

  1. Erin L. Van Blarigan
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  2. Stacey A. Kenfield
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  3. Meng Yang
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  4. Howard D. Sesso
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  5. Jing Ma
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  6. Meir J. Stampfer
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  7. June M. Chan
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  8. Jorge E. Chavarro
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Corresponding author

Correspondence toErin L. Van Blarigan.

Additional information

Dr. Van Blarigan and Dr. Kenfield contributed equally to this work.

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Van Blarigan, E.L., Kenfield, S.A., Yang, M. et al. Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study.Cancer Causes Control 26, 1117–1126 (2015). https://doi.org/10.1007/s10552-015-0606-4

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