Hyperserotoninemia and Altered Immunity in Autism (original) (raw)
References
Abramson, R. K., Self, S., Genco, P., Smith, N., Pendleton, A., Valentine, J., Wright, H. H., Cuccaro, M., & Powell, D. (1990). The relationship between lymphocyte cell surface markers and serotonin in autistic probands. American Journal of Human Genetics, 47, A45. Google Scholar
Ameisen, J. C., Meade, R., & Askenase, P. W. (1989). A new interpretation of the involvement of serotonin in delayed-type hypersensitivity. Serotonin-2 receptor antagonists inhibit contact sensitivity by an effect on T cells. Journal of Immunology, 142, 3171–3179. Google Scholar
Anderson, G. M., Feibel, F. C., & Cohen, D. J. (1987a). Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Science, 40, 1063–1070. Article Google Scholar
Anderson, G. M., Freedman, D. X., Cohen, D. J., Volkmar, F. R., Hoder, E. L., McPhedran, P., Minderaa, R. B., Hansen, C. R., & Young, J. G. (1987b). Whole blood serotonin in autistic and normal subjects. Journal of Child Psychology and Psychiatry, 28, 885–900. Article Google Scholar
Anderson, G. M., Gutknecht, L., Cohen, D. J., Brailly-Tabard, S., Cohen, J. H., Ferrari, P., Roubertoux, P. L., & Tordjman, S. (2002). Serotonin transporter promoter variants in autism: Functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry, 7, 831–836. ArticlePubMed Google Scholar
Askenase, P. W., Herzog, W. R., Millet, I., Paliwal, V., Ramabhadran, R., Rochester, C., Geba, G. P., & Ptak, W. (1991). Serotonin initiation of delayed-type hypersensitivity: mediation by a primitive Thy-1+ antigen-specific clone or by specific monoclonal IgE antibody. Skin Pharmacol, 4(Suppl 1), 25–42. ArticlePubMed Google Scholar
Aune, T. M., Golden, H. W., McGrath, K. M. (1994). Inhibitors of serotonin synthesis and antagonists of serotonin 1A receptors inhibit T lymphocyte function in vitro and cell-mediated immunity in vivo. Journal of Immunology, 153, 489–498. Google Scholar
Aune, T. M., McGrath, K. M., Sarr, T., Bombara, M. P. & Kelley, K. A. (1993). Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. Journal of Immunology, 151, 1175–1183. Google Scholar
Betancur, C., Corbex, M., Spielewoy, C., Philippe, A., Laplanche, J. L., Launay, J. M., Gillberg, C., Mouren-Simeoni, M. C., Hamon, M., Giros, B., Nosten-Bertrand, M., & Leboyer, M. (2002). Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder. Molecular Psychiatry, 7, 67–71. ArticlePubMed Google Scholar
Black, C., Kaye, J. A., & Jick, H. (2002). Relation of childhood gastrointestinal disorders to autism: Nested case-control study using data from the UK General Practice Research Database. BMJ, 325, 419–421. ArticlePubMed Google Scholar
Bonnet, M., Lespinats, G., & Burtin, C. (1984). Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and allogeneic cells. Cell Immunology, 83, 280–291. Article Google Scholar
Chess, S., (1971). Autism in children with congenital rubella. Journal of Autism and Childhood Schizophrenia, 1, 33–47. ArticlePubMed Google Scholar
Chugani, D. C., Muzik, O., Behen, M., Rothermel, R., Janisse, J. J., Lee, J., & Chugani, H. T. (1999). Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Annals of Neurology, 45, 287–295. ArticlePubMed Google Scholar
Chugani, D. C., Muzik, O., Rothermel, R., Behen, M., Chakraborty, P., Mangner, T., da Silva, E. A., & Chugani, H. T. (1997). Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Annals of Neurology, 42, 666–669. ArticlePubMed Google Scholar
Cohen, D. J., Shaywitz, B. A., Johnson, W. T., & Bowers, M., Jr. (1974). Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid. Archives of General Psychiatry, 31, 845–853. Google Scholar
Comi, A. M., Zimmerman, A. W., Frye, V. H., Law, P. A., & Peeden, J. N. (1999). Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. Journal of Child Neurology, 14, 388–394. ArticlePubMed Google Scholar
Connolly, A. M., Chez, M. G., Pestronk, A., Arnold, S. T., Mehta, S., & Deuel, R. K. (1999). Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. Journal of Pediatrics, 134, 607–613. ArticlePubMed Google Scholar
Cook, E. H., Jr., Arora, R. C., Anderson, G. M., Berry-Kravis, E. M., Yan, S. Y., Yeoh, H. C., Sklena, P. J., Charak, D. A., & Leventhal, B. L. (1993a). Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life Science, 52, 2005–2015.
Cook, E. H., Jr., Courchesne, R., Lord, C., Cox, N. J., Yan, S., Lincoln, A., Haas, R., Courchesne, E., & Leventhal, B. L. (1997). Evidence of linkage between the serotonin transporter and autistic disorder. Molecular Psychiatry, 2, 247–250. Google Scholar
Cook, E. H., Jr., Leventhal, B. L., & Freedman, D. X. (1988). Free serotonin in plasma: Autistic children and their first-degree relatives. Biological Psychiatry, 24, 488–491. Google Scholar
Cook, E. H., Jr., Leventhal, B. L., Heller, W., Metz, J., Wainwright, M., & Freedman, D. X. (1990). Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence. Journal of Neuropsychiatry and Clinical Neurosciences, 2, 268–274. Google Scholar
Cook, E. H., Jr., Perry, B. D., Dawson, G., Wainwright, M. S., & Leventhal, B. L. (1993b). Receptor inhibition by immunoglobulins: Specific inhibition by autistic children, their relatives, and control subjects. Journal of Autism and Developmental Disorders, 23, 67–78. Google Scholar
Courchesne, E., Carper, R., & Akshoomoff, N. (2003). Evidence of brain overgrowth in the first year of life in autism. JAMA, 290, 337–344. ArticlePubMed Google Scholar
Croonenberghs, J., Delmeire, L., Verkerk, R., Lin, A. H., Meskal, A., Neels, H., Van der, P. M., Scharpe, S., Deboutte, D., Pison, G., & Maes, M. (2000). Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder. Neuropsychopharmacology, 22, 275–283. Google Scholar
Curin, J. M., Terzic, J., Petkovic, Z. B., Zekan, L., Terzic, I. M., & Susnjara, I. M. (2003). Lower cortisol and higher ACTH levels in individuals with autism. Journal of Autism and Developmental Disorders, 33, 443–448. ArticlePubMed Google Scholar
DeFelice, M. L., Ruchelli, E. D., Markowitz, J. E., Strogatz, M., Reddy, K. P., Kadivar, K., Mulberg, A. E., & Brown, K. A. (2003). Intestinal cytokines in children with pervasive developmental disorders. American Journal of Gastroenterology, 98, 1777–1782. ArticlePubMed Google Scholar
DelGiudice-Asch, G., & Hollander, E. (1997). Altered immune function in autism. CNS Spectrums, 2, 61–67. Google Scholar
Denney, D. R., Frei, B. W., & Gaffney, G. R. (1996). Lymphocyte subsets and interleukin-2 receptors in autistic children. Journal of Autism and Developmental Disorders, 26, 87–97. ArticlePubMed Google Scholar
Dietsch, G. N., & Hinrichs, D. J. (1989). The role of mast cells in the elicitation of experimental allergic encephalomyelitis. Journal of Immunology, 142, 1476–1481. Google Scholar
Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297–321. ArticlePubMed Google Scholar
Foon, K. A., Wahl, S. M., Oppenheim, J. J., & Rosenstreich, D. L. (1976). Serotonin-induced production of a monocyte chemotactic factor by human peripheral blood leukocytes. Journal of Immunology, 117, 1545–1552. Google Scholar
Gabrilovac, J., Cicin-Sain, L., Osmak, M., & Jernej, B. (1992). Alteration of NK- and ADCC-activities in rats genetically selected for low or high platelet serotonin level. Journal of Neuroimmunology,37, 213–222. ArticlePubMed Google Scholar
Geba, G. P., Ptak, W., Anderson, G. M., Paliwal, V., Ratzlaff, R. E., Levin, J., & Askenase, P. W. (1996). Delayed-type hypersensitivity in mast cell-deficient mice: dependence on platelets for expression of contact sensitivity. Journal of Immunology, 157, 557–565. Google Scholar
Gillberg, C., Svennerholm, L., & Hamilton-Hellberg, C. (1983). Childhood psychosis and monoamine metabolites in spinal fluid. Journal of Autism and Developmental Disorders, 13, 383–396. ArticlePubMed Google Scholar
Gray, R. S., McCorkle, F. M., Denno, K. M., & Taylor, R. L., Jr. (1991). Modulation of chicken plaque-forming cells by serotonin and dopamine. Poultry Science, 70, 1521–1526. Google Scholar
Hanley, H. G., Stahl, S. M., & Freedman, D. X. (1977). Hyperserotonemia and amine metabolites in autistic and retarded children. Archives of General Psychiatry, 34, 521–531. PubMed Google Scholar
Hellstrand, K., Czerkinsky, C., Ricksten, A., Jansson, B., Asea, A., Kylefjord, H., & Hermodsson, S. (1993). Role of serotonin in the regulation of interferon-gamma production by human natural killer cells. Journal of Interferon Research, 13, 33–38. PubMed Google Scholar
Hellstrand, K., & Hermodsson, S. (1987). Role of serotonin in the regulation of human natural killer cell cytotoxicity. Journal of Immunology, 139, 869–875. Google Scholar
Hellstrand, K., & Hermodsson, S. (1990). Enhancement of human natural killer cell cytotoxicity by serotonin: Role of non-T/CD16+ NK cells, accessory monocytes, and 5-HT1A receptors. Cell Immunology, 127, 199–214. Article Google Scholar
Henson, P. M., & Spiegelberg, H. L. (1973). Release of serotonin from human platelets induced by aggregated immunoglobulins of different classes and subclasses. Journal of Clinical Investigation, 52, 1282–1288. ArticlePubMed Google Scholar
Hérault, J., Petit, E., Martineau, J., Cherpi, C., Perrot, A., Barthélémy, C., Lelord, G., & Müh, J. P. (1996). Serotonin and autism: Biochemical and molecular biology features. Psychiatry Research, 65, 33–43. ArticlePubMed Google Scholar
Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tildon, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics, 135, 559–563. ArticlePubMed Google Scholar
Huh, G. S., Boulanger, L. M., Du, H., Riquelme, P. A., Brotz, T. M., & Shatz, C. J. (2000). Functional requirement for class I MHC in CNS development and plasticity. Science, 290, 2155–2159. ArticlePubMed Google Scholar
Jackson, J. C., Cross, R. J., Walker, R. F., Markesbery, W. R., Brooks, W. H., & Roszman, T. L. (1985). Influence of serotonin on the immune response. Immunology, 54, 505–512. PubMed Google Scholar
Jackson, J. C., Walker, R. F., Brooks, W. H., & Roszman, T. L. (1988). Specific uptake of serotonin by murine macrophages. Life Science, 42, 1641–1650. Article Google Scholar
Kemper, T. L., Bauman, M. (1998). Neuropathology of infantile autism. Journal of Neuropathology and Experimental Neurology, 57, 645–652. ArticlePubMed Google Scholar
Khan, N.-A., & Poisson, J.-P. (1999). 5-HT3 receptor-channels coupled with Na+ influx in human T cells: Role in T cell activation. Journal of Neuroimmunology, 99, 53–60. ArticlePubMed Google Scholar
Klareskog, L., Forsum, U., Scheynius, A., Kabelitz, D., & Wigzell, H. (1982). Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis. Proceedings of the National Academy of Sciences of the USA, 79, 3632–3636. ArticlePubMed Google Scholar
Klauck, S. M., Poustka, F., Benner, A., Lesch, K. P., & Poustka, A. (1997). Serotonin transporter (5-HTT) gene variants associated with autism? Human Molecular Genetics, 6, 2233–2238. ArticlePubMed Google Scholar
Kuperman, S., Beeghly, J. H., Burns, T. L., & Tsai, L. Y. (1985). Serotonin relationships of autistic probands and their first-degree relatives. Journal of the American Academy of Child and Adolescent Psychiatry, 24, 186–190. Article Google Scholar
Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., & Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531. ArticlePubMed Google Scholar
Linden, D. R., Chen, J.-X., Gershon, M. D., Sharkey, K. A., & Mawe, G. M. (2003). Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 285, G207–G216. PubMed Google Scholar
Maestrini, E., Lai, C., Marlow, A., Matthews, N., Wallace, S., Bailey, A., Cook, E. H., Jr., Weeks, D. E., & Monaco, A. P. (1999). Serotonin transporter (5-HTT) and γ-aminobutyric acid receptor subunit β3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. The International Molecular Genetic Study of Autism Consortium. American Journal of Medical Genetics, 88, 492–496. Google Scholar
Marchetti, B., Scifo, R., Batticane, N., & Scapagnini, U. (1990). Immunological significance of opioid peptide dysfunction in infantile autism. Brain Dysfunction, 3, 346–354. Google Scholar
Mårtensson, U., & Nässberger, L. (1993). Influence of antidepressants on mitogen stimulation of human lymphocytes. Toxic in Vitro, 7, 241–245. Article Google Scholar
McBride, P. A., Anderson, G. M., Hertzig, M. E., Snow, M. E., Thompson, S. M., Khait, V. D., Shapiro, T., & Cohen, D. J. (1998). Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 767–776. ArticlePubMed Google Scholar
McBride, P. A., Anderson, G. M., Hertzig, M. E., Sweeney, J. A., Kream, J., Cohen, D. J., & Mann, J. J. (1989). Serotonergic responsivity in male young adults with autistic disorder. Results of a pilot study. Archives of General Psychiatry, 46, 213–221. PubMed Google Scholar
McDougle, C. J., Holmes, J. P., Carlson, D. C., Pelton, G. H., Cohen, D. J., & Price, L. H. (1998). A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Archives of General Psychiatry, 55, 633–641. ArticlePubMed Google Scholar
McDougle, C. J., Naylor, S. T., Cohen, D. J., Aghajanian, G. K., Heninger, G. R., & Price, L. H. (1996a). Effects of tryptophan depletion in drug-free adults with autistic disorder. Archives of General Psychiatry, 53, 993–1000. Google Scholar
McDougle, C. J., Naylor, S. T., Cohen, D. J., Volkmar, F. R., Heninger, G. R., & Price, L. H. (1996b). A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Archives of General Psychiatry, 53, 1001–1008. Google Scholar
Ménage, P., Thibault, G., Barthélémy, C., Lelord, G., & Bardos, P. (1992). CD4+ CD45RA+ T lymphocyte deficiency in autistic children: Effect of a pyridoxine-magnesium treatment. Brain Dysfunction, 5, 326–333. Google Scholar
Minderaa, R. B., Anderson, G. M., Volkmar, F. R., Akkerhuis, G. W., & Cohen, D. J. (1987). Urinary 5-hydroxyindoleacetic acid and whole blood serotonin and tryptophan in autistic and normal subjects. Biological Psychiatry, 22, 933–940. ArticlePubMed Google Scholar
Money, J., Bobrow, N. A., & Clarke, F. C. (1971). Autism and autoimmune disease: A family study. Journal of Autism and Childhood Schizophrenia, 1, 146–160. ArticlePubMed Google Scholar
Mössner, R., & Lesch, K.-P. (1998). Role of serotonin in the immune system and in neuroimmune interactions. Brain Behavior and Immunity, 12, 249–271. Article Google Scholar
Mulder, E. J., Anderson, G. M., Kema, I. P., de Bildt, A., van Lang, N. D., den Boer, J. A., Minderaa, R. B. (2004). Platelet serotonin levels in pervasive developmental disorders and mental retardation: diagnostic group differences, within-group distribution, and behavioral correlates. Journal of the American Academy of Child and Adolescent Psychiatry, 43, 491–499. ArticlePubMed Google Scholar
Paegelow, I., Werner, H., Hagen, M., Wartner, U., & Lange, P. (1985). Influence of serotonin on lymphokine secretion in vitro. International Journal of Immunopharmacology, 7, 889–896. ArticlePubMed Google Scholar
Perry, B. D., Cook, E. H., Jr., Leventhal, B. L., Wainwright, M. S., & Freedman, D. X. (1991). Platelet 5-HT2 serotonin receptor binding sites in autistic children and their first-degree relatives. Biological Psychiatry, 30, 121–130. Google Scholar
Persico, A. M., Militerni, R., Bravaccio, C., Schneider, C., Melmed, R., Conciatori, M., Damiani, V., Baldi, A., & Keller, F. (2000). Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. American Journal of Medical Genetics, 96, 123–127. ArticlePubMed Google Scholar
Plioplys, A. V. (1998). Intravenous immunoglobulin treatment of children with autism. Journal of Child Neurology, 13, 79–82. ArticlePubMed Google Scholar
Plioplys, A. V., Greaves, A., Kazemi, K., & Silverman, E. (1994). Lymphocyte function in autism and Rett syndrome. Neuropsychobiology, 29, 12–16. ArticlePubMed Google Scholar
Poljak-Blazi, M., Jernej, B., Cicin-Sain, L., Boranic, M. (1990). Immunological response of rats selected for high or low platelet serotonin content. Periodicum Biologorum, 92, 189–190. Google Scholar
Rogers, T., Kalaydjieva, L., Hallmayer, J., Petersen, P. B., Nicholas, P., Pingree, C., McMahon, W. M., Spiker, D., Lotspeich, L., Kraemer, H., McCague, P., Dimiceli, S., Nouri, N., Peachy, T., Yang, J., Hinds, D., Risch, N., & Myers, R.M. (1999). Exclusion of linkage to the HLA region in ninety multiplex sibships with autism. Journal of Autism and Developmental Disorders, 29, 195–201. ArticlePubMed Google Scholar
Schain, R. J., & Freedman, D. X. (1961). Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. Journal of Pediatrics, 58, 315–320. ArticlePubMed Google Scholar
Scifo, R., Cioni, M., Nicolosi, A., Batticane, N., Tirolo, C., Testa, N., Quattropani, M. C., Morale, M. C., Gallo, F., & Marchetti, B. (1996). Opioid-immune interactions in autism: behavioural and immunological assessment during a double-blind treatment with naltrexone. Annali dell’Istituo Superiore di Sanita, 32, 351–359. Google Scholar
Singh, V. K., & Rivas, W. H. (2004). Prevalence of serum antibodies to caudate nucleus in autistic children. Neuroscience Letters, 355, 53–56. ArticlePubMed Google Scholar
Singh, V. K., Singh, E. A., & Warren, R. P. (1997). Hyperserotoninemia and serotonin receptor antibodies in children with autism but not mental retardation. Biological Psychiatry, 41, 753–755. ArticlePubMed Google Scholar
Singh, V. K., Warren, R. P., Odell, J. D., Warren, W. L., & Cole, P. (1993). Antibodies to myelin basic protein in children with autistic behavior. Brain Behavior and Immunity, 7, 97–103. Article Google Scholar
Singh, V. K., Warren, R. P., & Singh, E. A. (1990). Binding of 3H serotonin to lymphocytes in patients with neuropsychiatric disorders. Molecular and Chemical Neuropathology, 13, 167–173. ArticlePubMed Google Scholar
Slauson, D. O., Walker, C., Kristensen, F., Wang, Y., & de Weck, A. L. (1984). Mechanisms of serotonin-induced lymphocyte proliferation inhibition. Cell Immunology, 84, 240–252. Article Google Scholar
Sternberg, E. M., Trial, J., & Parker, C. W. (1986). Effect of serotonin on murine macrophages: suppression of Ia expression by serotonin and its reversal by 5-HT2 serotonergic receptor antagonists. Journal of Immunology, 137, 276–282. Google Scholar
Stubbs, E.G. (1978). Autistic symptoms in a child with congenital cytomegalovirus infection. Journal of Autism and Childhood Schizophrenia, 8, 37–43. ArticlePubMed Google Scholar
Stubbs, E. G., Crawford, M. L., Burger, D. R., Vandenbark, A. A. (1977). Depressed lymphocyte responsiveness in autistic children. Journal of Autism and Childhood Schizophrenia, 7, 49–55. ArticlePubMed Google Scholar
Sweeten, T. L., Bowyer, S. L., Posey, D. J., Halberstadt, G. M., & McDougle, C. J. (2003). Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics, 112, e420. ArticlePubMed Google Scholar
Sweeten, T. L., Posey, D. J., & McDougle, C. J. (2004). Autistic disorder in three children with cytomegalovirus infection. Journal of Autism and Developmental Disorders, 34, 583–586. ArticlePubMed Google Scholar
Sweeten, T. L., Posey, D. J., Shekhar, A., & McDougle, C. J. (2002). The amygdala and related structures in the pathophysiology of autism. Pharmacology Biochemistry and Behavior, 71, 449–455. Article Google Scholar
Todd, R. D., & Ciaranello, R. D. (1985). Demonstration of inter- and intraspecies differences in serotonin binding sites by antibodies from an autistic child. Proceedings of the National Academy of Sciences of the USA, 82, 612–616. ArticlePubMed Google Scholar
Torres, A. R., Maciulis, A., Stubbs, E. G., Cutler, A., & Odell, D. (2002). The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder. Human Immunology, 63, 311–316. ArticlePubMed Google Scholar
van Gent, T., Heijnen, C. J., & Treffers, P. D. (1997). Autism and the immune system. Journal of Child Psychology and Psychiatry, 38, 337–349. ArticlePubMed Google Scholar
Veenstra-VanderWeele, J., Kim, S. J., Lord, C., Courchesne, R., Akshoomoff, N., Leventhal, B. L., Courchesne, E., & Cook, E. H., Jr. (2002). Transmission disequilibrium studies of the serotonin 5-HT2A receptor gene (HTR2A) in autism. American Journal of Medical Genetics, 114, 277–283. Google Scholar
Wakefield, A. J., Anthony, A., Murch, S. H., Thomson, M., Montgomery, S. M., Davies, S., O’Leary, J. J., Berelowitz, M., & Walker-Smith, J. A. (2000). Enterocolitis in children with developmental disorders. American Journal Gastroenterology, 95, 2285–2295. Article Google Scholar
Walther, D. J., Peter, J. U., Bashammakh, S., Hortnagl, H., Voits, M., Fink, H., & Bader, M. (2003). Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science, 299, 76. ArticlePubMed Google Scholar
Warren, R. P., Foster A. & Margaretten, N. C. (1987). Reduced natural killer cell activity in autism. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 333–335 ArticlePubMed Google Scholar
Warren, R. P., Kane, K. K., Burger, R. A., Singh, V. K. (1990). Serotonin-induced suppression of lymphocyte DNA synthesis and natural killer cell activity. Annals of the New York Academy of Sciences, 594, 429–431. Article Google Scholar
Warren, R. P., Margaretten, N. C., Pace, N. C., & Foster, A. (1986). Immune abnormalities in patients with autism. Journal of Autism and Developmental Disorders, 16, 189–197. ArticlePubMed Google Scholar
Warren, R. P., & Singh, V. K. (1996). Elevated serotonin levels in autism: Association with the major histocompatibility complex. Neuropsychobiology, 34, 72–75. ArticlePubMed Google Scholar
Warren, R. P., Singh, V. K., Cole, P., Odell, J. D., Pingree, C. B., Warren, W. L., DeWitt, C. W., & McCullough, M. (1992). Possible association of the extended MHC haplotype B44-SC30-DR4 with autism. Immunogenetics, 36, 203–207. ArticlePubMed Google Scholar
Warren, R. P., Yonk, J., Burger, R. W., Odell, D., & Warren, W. L. (1995). DR-positive T cells in autism: Association with decreased plasma levels of the complement C4B protein. Neuropsychobiology, 31, 53–57. ArticlePubMed Google Scholar
Yirmiya, N., Pilowsky, T., Nemanov, L., Arbelle, S., Feinsilver, T., Fried, I., Ebstein, R. P. (2001). Evidence for an association with the serotonin transporter promoter region polymorphism and autism. American Journal of Medical Genetics, 105, 381–386. ArticlePubMed Google Scholar
Young, M. R. I., Kut, J. L., Coogan, M. P., Wright, M. A., Young, M. E., & Matthews, J. (1993). Stimulation of splenic T-lymphocyte function by endogenous serotonin and by low-dose exogenous serotonin. Immunology, 80, 395–400. PubMed Google Scholar
Yuwiler, A., Shih, J. C., Chen, C. H., Ritvo, E. R., Hanna, G., Ellison, G. W., & King, B. H. (1992). Hyperserotoninemia and antiserotonin antibodies in autism and other disorders. Journal of Autism and Developmental Disorders, 22, 33–45. ArticlePubMed Google Scholar
Zhong, N., Ye, L., Ju, W., Brown, W. T., Tsiouris, J., & Cohen, I. (1999). 5-HTTLPR variants not associated with autistic spectrum disorders. Neurogenetics, 2, 129–131. ArticlePubMed Google Scholar