Increased serum interleukin 17 in patients with systemic lupus erythematosus (original) (raw)

Abstract

Interleukin 17 (IL-17) is a Th17 cytokine associated with inflammation, autoimmunity and defense against some bacteria, it has been implicated in many chronic autoimmune diseases including psoriasis, multiple sclerosis and systemic sclerosis. However, whether IL-17 plays a role in the pathogenesis of systemic lupus erythematosus (SLE) remains unclear. In the present study, we aimed to investigate the serum IL-17 level in patients with SLE and it’s associations with disease manifestations and activity. Fifty-seven patients with SLE and 30 healthy volunteers were recruited. Serum IL-17 levels were examined by enzyme linked immunosorbent assay (ELISA). Statistic analyzes were performed by SPSS 10.01. Results show that serum IL-17 levels were significantly elevated in SLE patients as compared with normal controls. Nevertheless, no associations of serum IL-17 level with clinical and laboratory parameters were found; no significant difference regarding serum IL-17 level between SLE patients with nephritis and those without nephritis was found; no significant difference was found between Less active SLE and More active SLE; Correlation analysis between serum IL-17 levels and SLEDAI showed no association. Taken together, our results indicate increased serum IL-17 levels in SLE patients, suggesting that this cytokine may trigger the inflammatory process in SLE. However, no associations of serum IL-17 level with disease manifestations were found. Therefore, further studies are required to confirm this preliminary data.

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Acknowledgments

This work was partly supported by grants from the National Natural Science Foundation of China (30571608, 30771848) and the key program of National Natural Science Foundation of China (30830089).

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Authors and Affiliations

1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, People’s Republic of China
   Xue-Fei Zhao, Hai-Feng Pan, Hui Yuan, Wen-Hui Zhang, Hong Su, Fa-Ming Pan, Wen-Xian Li, Lian-Hong Li, Guo-Ping Chen & Dong-Qing Ye
2. Department of Rheumatology, Anhui Provincial Hospital, 17 Lujiang Road, 230001, Hefei, Anhui, People’s Republic of China
   Xiang-Pei Li & Gui-Hong Wang
3. Department of Pharmacology, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, People’s Republic of China
   Guo-Cui Wu

Authors

1. Xue-Fei Zhao
2. Hai-Feng Pan
3. Hui Yuan
4. Wen-Hui Zhang
5. Xiang-Pei Li
6. Gui-Hong Wang
7. Guo-Cui Wu
8. Hong Su
9. Fa-Ming Pan
10. Wen-Xian Li
11. Lian-Hong Li
12. Guo-Ping Chen
13. Dong-Qing Ye

Corresponding author

Correspondence toDong-Qing Ye.

Additional information

X.-F. Zhao and H.-F. Pan contributed equally to this work and should be considered co-first authors.

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Zhao, XF., Pan, HF., Yuan, H. et al. Increased serum interleukin 17 in patients with systemic lupus erythematosus.Mol Biol Rep 37, 81–85 (2010). https://doi.org/10.1007/s11033-009-9533-3

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• Received: 11 September 2008
• Accepted: 28 January 2009
• Published: 04 April 2009
• Issue date: January 2010
• DOI: https://doi.org/10.1007/s11033-009-9533-3

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