The functional status of DNA repair pathways determines the sensitization effect to cisplatin in non-small cell lung cancer cells (original) (raw)

References

  1. C. Zeng, W. Fan, X. Zhang, RRMI expression is associated with the outcome of gemcitabine-based treatment of non-small cell lung cancer patients – a short report. Cell. Oncol. 38, 319–325 (2015)
    Article CAS Google Scholar
  2. E. Prodromaki, A. Korpetinou, E. Giannopoulou, E. Vlotinou, M. Chatziathanasiadou, N. I. Papachristou, C. D. Scopa, H. Papadaki, H. P. Kalofonos, D. J. Papachristou, Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinoma. Cell. Oncol. 38, 307–317 (2015)
    Article CAS Google Scholar
  3. Z. B. Cincin, M. Unlu, B. Kiran, E. S. Bireller, Y. Baran, B. Cakmakoglu, Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells. Cell. Oncol. 38, 195–204 (2015)
    Article Google Scholar
  4. S. N. Bichev, D. M. Marinova, Y. G. Slavova, A. S. Savov, Epidermal growth factor receptor mutations in east European non-small cell lung cancer patients. Cell. Oncol. 38, 145–153 (2015)
    Article CAS Google Scholar
  5. J. Cadranel, G. Zalcman, L. Sequist, Genetic profiling and epidermal growth factor receptor-directed therapy in nonsmall cell lung cancer. Eur. Respir. J. 37, 183–193 (2011)
    Article CAS PubMed Google Scholar
  6. M.A. Socinski, T. Evans, S. Gellinger, T.A. Hensing, L.V.D. Sequisct, B. Ireland, T.E. Stinchcombe, Treatment of stage VI non-small cell lung cancer: diagnosis and management of lung cancer 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 143 (suppl.), e341s-e368s (2013)
  7. I. A. Voutsadakis, The chemosensitivity of testicular germ cell tumors. Cell. Oncol. 37, 79–94 (2014)
    Article CAS Google Scholar
  8. L. Galluzzi, L. Senovilla, I. Vitale, J. Michels, I. Martins, O. Kepp, M. Castedo, G. kroemer, Molecular mechanisms of cisplatin resistance. Oncogene 31, 1869–1883 (2012)
    Article CAS PubMed Google Scholar
  9. Z. H. Siddik, Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22, 7265–7279 (2003)
    Article CAS PubMed Google Scholar
  10. X. Li, W. D. Heyer, Homologous recombination in DNA repair and DNA damage tolerance. Cell Res. 18, 99–113 (2008)
    Article CAS PubMed PubMed Central Google Scholar
  11. D. Branzei, M. Foiani, Maintaining genome stability to the replication fork. Nat. Rev. Mol. Cell Biol. 11, 208–219 (2010)
  12. W. L. de Laat, N. G. J. Jaspers, J. H. J. Hoeijmakers, Molecular mechanism of nucleotide excision repair. Genes Dev. 13, 768–785 (1999)
    Article PubMed Google Scholar
  13. Y. Jung, S. J. Lippard, Direct cellular responses to platinum-induced DNA damage. Chem. Rev. 107, 1387–1407 (2007)
    Article CAS PubMed Google Scholar
  14. N. Bhagwat, A. L. Olsen, A. T. Wang, K. Hanada, P. Stuchert, R. Kanaar, A. D’Andrea, L. J. Niedernhofer, P. J. McHugh, XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol. Cell. Biol. 29, 6427–6437 (2009)
    Article CAS PubMed PubMed Central Google Scholar
  15. M. Räschle, P. Knipscheer, M. Enoiu, T. Anggelou, J. Sun, J. D. Griffith, T. E. Ellenberger, O. D. Schärer, J. C. Walter, Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134, 969–980 (2008)
    Article PubMed PubMed Central Google Scholar
  16. Y. Kee, A. D. D’Andrea, Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev. 24, 1680–1694 (2010)
    Article CAS PubMed PubMed Central Google Scholar
  17. H. Kim, A.D. D’Andrea, Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev. 26, 1393–1408 (2012)
  18. S. J. Araujo, F. Tirode, F. Coin, H. Pospiech, J. E. Syvaoja, M. Stucki, U. Hubscher, J. M. Egly, R. D. Wood, Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors: active forms of TFIIH, and modulation by CAK. Genes Dev. 14, 349–359 (2000)
    CAS PubMed PubMed Central Google Scholar
  19. J. Michl, J. Zimmer, M. Tarsounas, Interplay between fanconi anemia and homologous recombination pathways in genome integrity. EMBO J. 35, 909–923 (2016)
    Article CAS PubMed PubMed Central Google Scholar
  20. J. Huang, M. S. Y. Huen, H. Kim, C. C. Y. Leung, J. N. M. Glover, X. Yu, J. Chen, RAD18 transmits DNA damage signaling to elicit homologous recombination repair. Nat. Cell Biol. 11, 592–603 (2009)
    Article CAS PubMed PubMed Central Google Scholar
  21. S. A. Williams, S. Longerich, P. Sung, C. Vaziri, G. M. Kupfer, The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromation loading of FANCD2 and FANCI. Blood 11, 5078–5087 (2011)
    Article Google Scholar
  22. M.A. Cohn, P. Kowal, K. Yang, W. Haas, T.T. Huang, S.P. Gggi, A.D. D’Andrea, A UAF1- Containing multisubunit protein. Mol. Cell 28, 786–789 (2007)
  23. R. Roy, J. Chun, S. N. Powell, BRCA1 and BRCA2: different role in a common pathway of genome protection. Nat. Rev. Cancer 12, 68–78 (2012)
    Article CAS Google Scholar
  24. M. E. Mognhan, A. J. Pierce, M. Jasin, BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263–272 (2001)
    Article Google Scholar
  25. Y. Qing, M. Yamazoe, K. Hirota, D. Dejsuphong, W. Sakai, K. N. Yamamoto, D. K. Bishop, X. Wu, S. Takeda, The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS Genet. 7, e1002148 (2011)
    Article CAS PubMed PubMed Central Google Scholar
  26. J. San Filippo, P. Sung, H. Klein, Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 77, 229–257 (2008)
  27. D. T. Long, M. Raschle, V. Joukov, J. C. Waeter, Mechanism of RAD51-dependent DNA interstrand cross-link repair. Science 333, 84–87 (2011)
    Article CAS PubMed PubMed Central Google Scholar
  28. M. Yamazoe, E. Sonoda, H. Hochegger, S. Takeda, Reverse genetic studies of the DNA damage response in the chicken B lymphocyte cells DT40. DNA Repair 3, 1175–1185 (2004)
    Article CAS PubMed Google Scholar
  29. K. Kurkitt, M. Ljungman, Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin. Mol. Cancer 7, 24 (2008)
    Article Google Scholar
  30. J. Chen, T. S. Dexheimer, Y. Ai, Q. Liang, M. A. Villamil, J. Inglese, D. J. Maloney, A. Jadhav, A. Simeonov, Z. Zhuang, Selective and cell-active inhibitors of the USP1/UAF1 deubiqitinase complex reverse cispcatin resistance in non-small cell lung cancer cells. Chem. Biol. 18, 1390–1400 (2011)
    Article CAS PubMed PubMed Central Google Scholar
  31. D. Chirnomas, T. Taniguchi, M. dela Vega, A. P. Vaidya, M. Vasserman, A.-R. Hartman, R. Kennedy, J. Mahoney, M. V. Seiden, A. D. D’Andrea, Chemosensitization to cisplatin by inhibitors of the Fanconi anemia BRCA pathway. Mol. Cancer Ther. 5, 952–961 (2006)
    Article CAS PubMed Google Scholar
  32. W. Duan, L. Gao, B. Aguila, A. Kalvala, G. A. Otterson, M. A. Villalona-Calero, Fanconi anemia repair pathway dysfunction, a potential therapeutic target in lung cancer. Front. Oncol. 4, 368 (2014)
    Article PubMed PubMed Central Google Scholar
  33. S. Arora, A. Kothandapani, K. Tillison, V. Kalman-Maltese, S. M. Patrick, Downregulation of XPE-ERCC1 enhance cisplatin efficacy in cancer cells. DNA Repair 9, 745–753 (2010)
    Article CAS PubMed PubMed Central Google Scholar
  34. P. Chen, J. Li, H.-G. Jiang, T. Lan, Y.-C. Chen, Curcumin reverses cisplatin resistance in cisplatin-resistant lung cancer cells by inhibiting FA/BRCA pathway. Tumor Biol. 36, 3591–3599 (2015)
    Article CAS Google Scholar
  35. C.-H. Dai, J. Li, P. Chen, H.-G. Jiang, M. Wu, Y.-C. Chen, RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistance lung cancer cells. J. Biomed. Sci. 22, 77 (2015)
    Article PubMed PubMed Central Google Scholar
  36. A. Rothfuss, M. Grompe, Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol. Cell. Biol. 24, 123–134 (2004)
    Article CAS PubMed PubMed Central Google Scholar
  37. F. Cavallo, G. Graziani, C. Antinozzi, D.R. Feldman, J. Houldswoth, G.J. Bosl, R.S. Chaganti, M.E. Moynahan, M. Jasin, M. Barchi, Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to cisplatin and poly (ADP-ribose) polymerase inhibition. PLoS One 7, e51563 (2012)
  38. C. Plasencia, E. Martinez-Balibrea, A. Martinez-Cardus, D. I. Quinn, A. Abad, N. Neamati, Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT 29 colon cancer cells. Int. J. Oncol. 29, 225–235 (2006)
    CAS PubMed Google Scholar
  39. P. H. Clingen, J. Y. Wu, J. Miller, N. Mistry, F. Chin, P. .Wynne, K. M. Prise, J. A. Hartley, Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstread crosslink cancer chemotherapy. Biochem. Pharmacol. 76, 19–29 (2008)
    Article CAS PubMed Google Scholar
  40. M. Huang, A. D. D’ Andrea, A new nuclease member of the FAN club. Nat. Struct. Mol. Biol. 17, 926–928 (2010)
    Article CAS PubMed PubMed Central Google Scholar
  41. A. Ciccia, N. McDonal, S. C. West, Structural and functional relationships of the XPE/Mus 81 family of proteins. Annu. Rev. Biochem. 77, 259–287 (2008)
    Article CAS PubMed Google Scholar
  42. M. R. Hodskinson, J. Silhan, G. P. Crossan, J. I. Garaycoe-chea, S. Mukherjee, C. M. Johnson, O. D. Scharer, K. J. Patel, Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPE-ERCC1 in DNA crosslink repair. Mol. Cell 54, 472–484 (2014)
    Article CAS PubMed PubMed Central Google Scholar
  43. M. Selvakumaran, D. A. Pisarcik, R. Bao, A. T. Yeung, T. C. Hamilton, Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines. Cancer Res. 63, 1311–1316 (2003)
    CAS PubMed Google Scholar
  44. X. Wu, W. Fan, S. Xu, Y. Zhou, Sensitization to the cytotoxicity of cisplatin by transfection with nucleotide excision repair gene xeroderma pigmentosum group a antisense RNA in human lung adenocarcinoma cell. Clin. Cancer Res. 9, 5874–5879 (2003)
    CAS PubMed Google Scholar
  45. B. Orelli, T. B. McClendon, O. V. Tsodikov, T. Ellenberger, L. J. Miedernhofer, O. D. Scharer, The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathway. J. Biol. Chem. 28, 3705–3712 (2010)
    Article Google Scholar
  46. M. Cummings, K. Higginbotton, C. J. McGurk, O. G. Wong, B. Koberle, R. T. Oliver, J. R. Masters, XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair. Biochem. Pharmacol. 72, 166–175 (2006)
    Article CAS PubMed Google Scholar
  47. L. J. Niedernhofer, H. Odijk, M. Budzowska, E. van Drumen, A. Maas, A. F. Theil, J. de Wit, N. G. Jasper, H. B. Beverloo, J. H. Hoeijmakers, R. Kanaar, The structure-specific endonuclease Ercc-Xpf is required to resolve DNA interstrand cross-link-induced double breaks. Mol. Cell. Biol. 24, 5776–5787 (2004)
    Article CAS PubMed PubMed Central Google Scholar
  48. S. Usanova, A. Piee-Staffa, U. Sied, J. Thomale, A. Schneider, B. Kaina, B. Koberle, Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crasslink repair and low ERCC1-XPE expression. Mol. Cancer 9, 248 (2010)
    Article PubMed PubMed Central Google Scholar
  49. Y. Huang, J. W. C. Leung, M. Lowery, N. Matsushita, Y. Wang, X. Shen, D. Huong, M. Takata, J. Chen, L. Li, Modularized functions of the Fanconi anemia core complex. Cell Rep. 7, 1–9 (2014)
    Article Google Scholar

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