Ibtisam SENUSSI | Misurata University (original) (raw)
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University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca
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Papers by Ibtisam SENUSSI
Journal of Advanced Research in Dental & Oral Health, 2019
Background: Class II division 1 malocclusion can be produced by protrusion of upper anterior teet... more Background: Class II division 1 malocclusion can be produced by protrusion of upper anterior teeth with normal maxillary basis relationship, that can be as a result of mandibular deficiency with normal dental position or posterior rotation of the mandible due to the excessive vertical growth of the maxilla. Deep bite usually associated with class II malocclusion, in which the mandibular incisor crowns are excessively overlapped vertically by the maxillary incisors where the teeth are in centric occlusion, which can be seen in children as well as in adults. So that for the successful treatment of Class II/ 1 required controlling the deep bite before starting the virtual treatment of this malocclusion to get better retention. Aim: The aim of this study was to investigate the morphological changes in maxillary and mandibular bones relationship after using the anterior bite plane appliance. Material and Methods: Evaluative analysis of cephalograms by superimposing two lateral cephalograms before and after the treatment of 27 patients (12 girls and 15 boys) class II division 1 malocclusion with mean age 11.7 years old. They treated by utilization of anterior bite plane while the period of fixed orthodontic therapy. Cephalometric data were analyzed with the following methods: Delaire, Danguy and classical and the morphological changes were evaluated. Results: The results of superposition of every patient before and after treatment showed a significant (P<0.05) reduction of deep bite and the facial convexity reduced in an average of 2.49°, anterior-posterior discrepancy reduced also very significantly (P=0.001), with a mean value of 1.81° and increasing in total mandibular length with a mean value of 2.95 mm. The decrease of the overbite can be due especially to the mandibular rotation and also supra-eruption of posterior teeth. Change in the mandibular length and the maxillary position improved facial profile but did not correct it completely as the mandible moved forward and also downward due to vertical and horizontal ramus growth and condylar remodeling.
Bone, 2014
The homeobox gene Msx1 encodes a transcription factor that is highly expressed during embryogenes... more The homeobox gene Msx1 encodes a transcription factor that is highly expressed during embryogenesis and postnatal development in bone. Mutations of the MSX1 gene in humans are associated with cleft palate and (or) tooth agenesis. A similar phenotype is observed in newborn mice invalidated for the Msx1 gene. However, little is known about Msx1 function in osteoblast differentiation and bone mineralization in vivo. In the present study, we aimed to explore the variations of individualized bone shape in a subtle way avoiding the often severe consequences associated with gene mutations. We established transgenic mice that specifically express Msx1 in mineral-matrix-secreting cells under the control of the mouse 2.3 kb collagen 1 alpha 1 (Col1α1) promoter, which enabled us to investigate Msx1 function in bone in vivo. Adult transgenic mice (Msx1-Tg) presented altered skull shape and mineralization resulting from increased Msx1 expression during bone development. Serial section analysis of the mandibles showed a high amount of bone matrix in these mice. In addition, osteoblast number, cell proliferation and apoptosis were higher in Msx1-Tg mice than in controls with regional differences that could account for alterations of bone shape. However, Von Kossa staining and μCT analysis showed that bone mineralization was lower in Msx1-Tg mice than in controls due to alteration of osteoblastic differentiation. Msx1 appears to act as a modeling factor for membranous bone; it stimulates trabecular bone metabolism but limits cortical bone growth by promoting apoptosis, and concomitantly controls the collagen-based mineralization process.
Rôle de Msx1 dans l’os : établissement d’un modèle animal surexprimant Msx1 dans les ostéoblastes
Le but de mon travail de these fut de generer un modele experimental qui permette de comprendre l... more Le but de mon travail de these fut de generer un modele experimental qui permette de comprendre les fonctions de Msx1 dans la mineralisation osseuse in vivo. Pour cela, un modele de souris transgeniques fut etabli a partir de l’ADNc Msx1 sous le controle du promoteur 2,3kb du collagene1a1. Les mandibules presentaient une augmentation du volume trabeculaire pouvant etre expliquee par un nombre accru d’osteoblastes et d’osteoclastes. Parallelement, l’apoptose etait egalement augmentee dans l’os cortical pouvant expliquer la limitation du volume osseux total. Ces resultats traduisent un metabolisme osseux accru en presence de Msx1 qui semble jouer un role trophique specifique de site. Parallelement, la mineralisation etait diminuee. Une analyse fine des resultats a montre une alteration du depot des fibres de collagene et une limitation de la differenciation terminale. Par ailleurs, l’analyse de la densite osseuse des os longs de souris adultes a montre une diminution de la qualite oss...
Journal of Advanced Research in Dental & Oral Health, 2019
Background: Class II division 1 malocclusion can be produced by protrusion of upper anterior teet... more Background: Class II division 1 malocclusion can be produced by protrusion of upper anterior teeth with normal maxillary basis relationship, that can be as a result of mandibular deficiency with normal dental position or posterior rotation of the mandible due to the excessive vertical growth of the maxilla. Deep bite usually associated with class II malocclusion, in which the mandibular incisor crowns are excessively overlapped vertically by the maxillary incisors where the teeth are in centric occlusion, which can be seen in children as well as in adults. So that for the successful treatment of Class II/ 1 required controlling the deep bite before starting the virtual treatment of this malocclusion to get better retention. Aim: The aim of this study was to investigate the morphological changes in maxillary and mandibular bones relationship after using the anterior bite plane appliance. Material and Methods: Evaluative analysis of cephalograms by superimposing two lateral cephalograms before and after the treatment of 27 patients (12 girls and 15 boys) class II division 1 malocclusion with mean age 11.7 years old. They treated by utilization of anterior bite plane while the period of fixed orthodontic therapy. Cephalometric data were analyzed with the following methods: Delaire, Danguy and classical and the morphological changes were evaluated. Results: The results of superposition of every patient before and after treatment showed a significant (P<0.05) reduction of deep bite and the facial convexity reduced in an average of 2.49°, anterior-posterior discrepancy reduced also very significantly (P=0.001), with a mean value of 1.81° and increasing in total mandibular length with a mean value of 2.95 mm. The decrease of the overbite can be due especially to the mandibular rotation and also supra-eruption of posterior teeth. Change in the mandibular length and the maxillary position improved facial profile but did not correct it completely as the mandible moved forward and also downward due to vertical and horizontal ramus growth and condylar remodeling.
Bone, 2014
The homeobox gene Msx1 encodes a transcription factor that is highly expressed during embryogenes... more The homeobox gene Msx1 encodes a transcription factor that is highly expressed during embryogenesis and postnatal development in bone. Mutations of the MSX1 gene in humans are associated with cleft palate and (or) tooth agenesis. A similar phenotype is observed in newborn mice invalidated for the Msx1 gene. However, little is known about Msx1 function in osteoblast differentiation and bone mineralization in vivo. In the present study, we aimed to explore the variations of individualized bone shape in a subtle way avoiding the often severe consequences associated with gene mutations. We established transgenic mice that specifically express Msx1 in mineral-matrix-secreting cells under the control of the mouse 2.3 kb collagen 1 alpha 1 (Col1α1) promoter, which enabled us to investigate Msx1 function in bone in vivo. Adult transgenic mice (Msx1-Tg) presented altered skull shape and mineralization resulting from increased Msx1 expression during bone development. Serial section analysis of the mandibles showed a high amount of bone matrix in these mice. In addition, osteoblast number, cell proliferation and apoptosis were higher in Msx1-Tg mice than in controls with regional differences that could account for alterations of bone shape. However, Von Kossa staining and μCT analysis showed that bone mineralization was lower in Msx1-Tg mice than in controls due to alteration of osteoblastic differentiation. Msx1 appears to act as a modeling factor for membranous bone; it stimulates trabecular bone metabolism but limits cortical bone growth by promoting apoptosis, and concomitantly controls the collagen-based mineralization process.
Rôle de Msx1 dans l’os : établissement d’un modèle animal surexprimant Msx1 dans les ostéoblastes
Le but de mon travail de these fut de generer un modele experimental qui permette de comprendre l... more Le but de mon travail de these fut de generer un modele experimental qui permette de comprendre les fonctions de Msx1 dans la mineralisation osseuse in vivo. Pour cela, un modele de souris transgeniques fut etabli a partir de l’ADNc Msx1 sous le controle du promoteur 2,3kb du collagene1a1. Les mandibules presentaient une augmentation du volume trabeculaire pouvant etre expliquee par un nombre accru d’osteoblastes et d’osteoclastes. Parallelement, l’apoptose etait egalement augmentee dans l’os cortical pouvant expliquer la limitation du volume osseux total. Ces resultats traduisent un metabolisme osseux accru en presence de Msx1 qui semble jouer un role trophique specifique de site. Parallelement, la mineralisation etait diminuee. Une analyse fine des resultats a montre une alteration du depot des fibres de collagene et une limitation de la differenciation terminale. Par ailleurs, l’analyse de la densite osseuse des os longs de souris adultes a montre une diminution de la qualite oss...