Seth Barishansky | Rutgers Robert Wood Johnson Medical School (original) (raw)

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Papers by Seth Barishansky

Research paper thumbnail of The Desire of Infertile Patients for Multiple Births: A Re-Examination with Updated Societal Guidelines and an Evolving Infertility Insurance Landscape

Fertility and Sterility, Apr 1, 2020

Between January 1976 and August 2001, endometrial samples from 87 women who underwent endometrial... more Between January 1976 and August 2001, endometrial samples from 87 women who underwent endometrial biopsy for abnormal uterine bleeding at the authors' institution were reported as "inadequate." The medical records of 76 women were suitable for review and were used to investigate the negative predictive value of inadequate endometrial specimens. Mean follow up was 26 months (range, 0-60 months). Follow-up management varied from observation to further diagnostic biopsy or ultrasound, or to treatment with hysteroscopy, dilation and curettage, or hysterectomy (Fig. 1). Fifty-five women were postmenopausal and 21 were premenopausal (mean age, 55 years). Follow-up tissue diagnoses were available for 37 women. In these patients, there was 1 histologic diagnosis of complex hyperplasia without atypia. Among the 38 women without follow-up tissue diagnoses, there were no reports of further bleeding.

Research paper thumbnail of What Happened Next? An Analysis of Pregnancy Outcomes in Patients Undergoing Frozen Blastocyst Transfer (FBT) Following a Previously Failed Cycle in a Randomized Controlled Trial Using Endometrial Receptivity Analysis (Era)

Fertility and Sterility, Jul 1, 2023

Research paper thumbnail of Not all intimate partner violence is physical and wealthy and/or white infertility patients are not immune to intimate partner violence

Research paper thumbnail of Factors, Motivations and Experiences of Infertility Patients Who Initially Considered Embryo Donation (Ed) with Supernumerary Embryos

Fertility and Sterility, Oct 1, 2022

Research paper thumbnail of Not all intimate partner violence is physical and wealthy and/or white infertility patients are not immune to intimate partner violence

Fertility and Sterility, Feb 1, 2023

Research paper thumbnail of Differences in Beliefs and Experiences of Embryo Donation (Ed) with or Without Use of Donor Gametes: A Survey Study

Research paper thumbnail of The parent trap: desire for multifetal gestation among patients treated for infertility

Journal of Assisted Reproduction and Genetics

Research paper thumbnail of Desire for Twin or Triplet Pregnancy in Infertility Patients and Patients Presenting for Planned Fertility Preservation (FP)

Fertility and Sterility, 2020

Research paper thumbnail of The Impact of COVID-19 on Fertility Care: An Evaluation of Society for Assisted Reproduction Technology (Sart) Member Clinics’ Websites

Fertility and Sterility, 2020

Objective: To evaluate the available COVID-19 content in regard to fertility care on the websites... more Objective: To evaluate the available COVID-19 content in regard to fertility care on the websites of Society for Assisted Reproductive Technology (SART) member clinics Design: Cross-sectional study Materials and Methods: From March 17 to March 30, 2020, following the release of the first American Society for Reproductive Medicine (ASRM) COVID-19 recommendations, SART member clinics’ websites were examined The presence of information on COVID-19 and pregnancy implications, acknowledgement of and compliance with ASRM recommendations, description of Centers for Disease Control and Prevention (CDC) risk mitigation strategies and local health department guidelines, as well as advertisement of telehealth and available mental health resources were queried Websites were categorized by practice size (small: <500 vs large: ≥500 cycles/year), type (academic vs private) and degree of statewide COVID-19 burden based on CDC data (low: 0-1000;high: ≥1000 diagnosed cases) Group differences were ...

Research paper thumbnail of Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid

International Journal of Molecular Sciences, 2021

The female reproductive system ages before any other organ system in the body. This phenomenon ca... more The female reproductive system ages before any other organ system in the body. This phenomenon can have tangible clinical implications leading to infertility, miscarriages, birth defects and systemic deterioration due to estrogen loss. “Fibroinflammation” is a hallmark of aging tissues; there is an increase in inflammatory cytokines and fibrotic tissue in the aging ovarian stroma. We systematically evaluated immunomodulatory factors in human follicular fluid, which, like the stroma, is a critical ovarian microenvironment directly influencing the oocyte. Using a cytokine antibody array, we identified a unique fibroinflammatory cytokine signature in follicular fluid across an aging series of women (27.7–44.8 years). This signature (IL-3, IL-7, IL-15, TGFβ1, TGFβ3 and MIP-1) increased with chronologic age, was inversely correlated to anti-Müllerian hormone (AMH) levels, and was independent of body mass index (BMI). We focused on one specific protein, TGFβ3, for further validation. By i...

Research paper thumbnail of Social Media in the Time of COVID-19: An Evaluation of Society for Assisted Reproductive Technology (Sart) Member Clinics

Objective: To evaluate the available COVID-19 content in regard to fertility care on the social m... more Objective: To evaluate the available COVID-19 content in regard to fertility care on the social media (SM) platforms from Society for Assisted Reproductive Technology (SART) member clinics Design: Cross-sectional study Materials and Methods: From March 17-30/2020, following the release of the first American Society for Reproductive Medicine (ASRM) COVID-19 recommendations, SART member clinics’ SM platforms including Facebook and Twitter were examined The presence of information on COVID-19, its pregnancy implications, acknowledgement of and compliance with ASRM recommendations, mention of Centers for Disease Control and Prevention (CDC) risk mitigation strategies and local health department guidelines, as well as advertisement for telehealth and availability of mental health resources were queried Websites were categorized by practice size (<500 vs ≥500 cycles/year), type (academic vs private) and degree of statewide COVID-19 burden based on CDC surveillance data (low: 0-1000;hig...

Research paper thumbnail of Reproductive endocrinologists’ knowledge and attitudes in the identification of intimate partner violence

Research paper thumbnail of Malnutrition is Associated with Poor Postoperative Outcomes Following Laparoscopic Hysterectomy

JSLS : Journal of the Society of Laparoscopic & Robotic Surgeons

Background:Malnutrition continues to be pervasive among the general population, with rates as hig... more Background:Malnutrition continues to be pervasive among the general population, with rates as high as 50% of patients undergoing surgical procedures. Data is limited about women undergoing surgery for non-malignant gynecologic indications (generally elective laparoscopic hysterectomies, after failed conservative measures). With the significant increase in benign gynecologic surgery, it is of the upmost importance that surgeons optimize modifiable risk factors for patients undergoing laparoscopic hysterectomy. The purpose of this study is to identify the impact of malnutrition on postoperative outcomes in patients undergoing laparoscopic hysterectomy for benign conditions.Methods:A retrospective cohort study was conducted utilizing data that was collected through the American College of Surgeon’s National Surgical Quality Improvement Program (NSQIP) Database. All patients that underwent laparoscopic hysterectomy for benign indications were identified. Patients with malnutrition were identified by either low albumin (≤ 3.5 g/dL), low body mass index (≤ 18.5), or 10% weight loss within 6 months. The frequency of postoperative complications was evaluated with univariate and multivariate analyses where appropriate.Results:Following adjustment, multivariate analysis illustrated pre-operative malnutrition to be a risk factor for the following complications: any complication, death, bleeding requiring transfusion, wound, cardiac, pulmonary, renal, thromboembolic, sepsis complications, extended length of stay, and reoperation (p ≤ 0.05 for all).Conclusion:Malnourished patients were at significantly higher risk of developing postoperative complications during the acute postoperative period. With elective laparoscopic hysterectomies, pre-operative evaluation and intervention for malnutrition should be considered to improve nutritional status.

Research paper thumbnail of Cytokine profiling reveals a unique inflammaging signature in human follicular fluid and the ovary

Research paper thumbnail of Impact of insurance coverage for fertility treatment on patient preference for singleton gestation

Research paper thumbnail of Perceptions of multifetal gestation amongst patients being treated for infertility

Research paper thumbnail of Safeguarding Trainee Health: A Call for an Annual Opt-Out Mental Health Screening

American Journal of Psychiatry Residents' Journal

Research paper thumbnail of The Desire of Infertile Patients for Multiple Births: A Re-Examination with Updated Societal Guidelines and an Evolving Infertility Insurance Landscape

Fertility and Sterility, Apr 1, 2020

Between January 1976 and August 2001, endometrial samples from 87 women who underwent endometrial... more Between January 1976 and August 2001, endometrial samples from 87 women who underwent endometrial biopsy for abnormal uterine bleeding at the authors' institution were reported as "inadequate." The medical records of 76 women were suitable for review and were used to investigate the negative predictive value of inadequate endometrial specimens. Mean follow up was 26 months (range, 0-60 months). Follow-up management varied from observation to further diagnostic biopsy or ultrasound, or to treatment with hysteroscopy, dilation and curettage, or hysterectomy (Fig. 1). Fifty-five women were postmenopausal and 21 were premenopausal (mean age, 55 years). Follow-up tissue diagnoses were available for 37 women. In these patients, there was 1 histologic diagnosis of complex hyperplasia without atypia. Among the 38 women without follow-up tissue diagnoses, there were no reports of further bleeding.

Research paper thumbnail of What Happened Next? An Analysis of Pregnancy Outcomes in Patients Undergoing Frozen Blastocyst Transfer (FBT) Following a Previously Failed Cycle in a Randomized Controlled Trial Using Endometrial Receptivity Analysis (Era)

Fertility and Sterility, Jul 1, 2023

Research paper thumbnail of Not all intimate partner violence is physical and wealthy and/or white infertility patients are not immune to intimate partner violence

Research paper thumbnail of Factors, Motivations and Experiences of Infertility Patients Who Initially Considered Embryo Donation (Ed) with Supernumerary Embryos

Fertility and Sterility, Oct 1, 2022

Research paper thumbnail of Not all intimate partner violence is physical and wealthy and/or white infertility patients are not immune to intimate partner violence

Fertility and Sterility, Feb 1, 2023

Research paper thumbnail of Differences in Beliefs and Experiences of Embryo Donation (Ed) with or Without Use of Donor Gametes: A Survey Study

Research paper thumbnail of The parent trap: desire for multifetal gestation among patients treated for infertility

Journal of Assisted Reproduction and Genetics

Research paper thumbnail of Desire for Twin or Triplet Pregnancy in Infertility Patients and Patients Presenting for Planned Fertility Preservation (FP)

Fertility and Sterility, 2020

Research paper thumbnail of The Impact of COVID-19 on Fertility Care: An Evaluation of Society for Assisted Reproduction Technology (Sart) Member Clinics’ Websites

Fertility and Sterility, 2020

Objective: To evaluate the available COVID-19 content in regard to fertility care on the websites... more Objective: To evaluate the available COVID-19 content in regard to fertility care on the websites of Society for Assisted Reproductive Technology (SART) member clinics Design: Cross-sectional study Materials and Methods: From March 17 to March 30, 2020, following the release of the first American Society for Reproductive Medicine (ASRM) COVID-19 recommendations, SART member clinics’ websites were examined The presence of information on COVID-19 and pregnancy implications, acknowledgement of and compliance with ASRM recommendations, description of Centers for Disease Control and Prevention (CDC) risk mitigation strategies and local health department guidelines, as well as advertisement of telehealth and available mental health resources were queried Websites were categorized by practice size (small: <500 vs large: ≥500 cycles/year), type (academic vs private) and degree of statewide COVID-19 burden based on CDC data (low: 0-1000;high: ≥1000 diagnosed cases) Group differences were ...

Research paper thumbnail of Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid

International Journal of Molecular Sciences, 2021

The female reproductive system ages before any other organ system in the body. This phenomenon ca... more The female reproductive system ages before any other organ system in the body. This phenomenon can have tangible clinical implications leading to infertility, miscarriages, birth defects and systemic deterioration due to estrogen loss. “Fibroinflammation” is a hallmark of aging tissues; there is an increase in inflammatory cytokines and fibrotic tissue in the aging ovarian stroma. We systematically evaluated immunomodulatory factors in human follicular fluid, which, like the stroma, is a critical ovarian microenvironment directly influencing the oocyte. Using a cytokine antibody array, we identified a unique fibroinflammatory cytokine signature in follicular fluid across an aging series of women (27.7–44.8 years). This signature (IL-3, IL-7, IL-15, TGFβ1, TGFβ3 and MIP-1) increased with chronologic age, was inversely correlated to anti-Müllerian hormone (AMH) levels, and was independent of body mass index (BMI). We focused on one specific protein, TGFβ3, for further validation. By i...

Research paper thumbnail of Social Media in the Time of COVID-19: An Evaluation of Society for Assisted Reproductive Technology (Sart) Member Clinics

Objective: To evaluate the available COVID-19 content in regard to fertility care on the social m... more Objective: To evaluate the available COVID-19 content in regard to fertility care on the social media (SM) platforms from Society for Assisted Reproductive Technology (SART) member clinics Design: Cross-sectional study Materials and Methods: From March 17-30/2020, following the release of the first American Society for Reproductive Medicine (ASRM) COVID-19 recommendations, SART member clinics’ SM platforms including Facebook and Twitter were examined The presence of information on COVID-19, its pregnancy implications, acknowledgement of and compliance with ASRM recommendations, mention of Centers for Disease Control and Prevention (CDC) risk mitigation strategies and local health department guidelines, as well as advertisement for telehealth and availability of mental health resources were queried Websites were categorized by practice size (<500 vs ≥500 cycles/year), type (academic vs private) and degree of statewide COVID-19 burden based on CDC surveillance data (low: 0-1000;hig...

Research paper thumbnail of Reproductive endocrinologists’ knowledge and attitudes in the identification of intimate partner violence

Research paper thumbnail of Malnutrition is Associated with Poor Postoperative Outcomes Following Laparoscopic Hysterectomy

JSLS : Journal of the Society of Laparoscopic & Robotic Surgeons

Background:Malnutrition continues to be pervasive among the general population, with rates as hig... more Background:Malnutrition continues to be pervasive among the general population, with rates as high as 50% of patients undergoing surgical procedures. Data is limited about women undergoing surgery for non-malignant gynecologic indications (generally elective laparoscopic hysterectomies, after failed conservative measures). With the significant increase in benign gynecologic surgery, it is of the upmost importance that surgeons optimize modifiable risk factors for patients undergoing laparoscopic hysterectomy. The purpose of this study is to identify the impact of malnutrition on postoperative outcomes in patients undergoing laparoscopic hysterectomy for benign conditions.Methods:A retrospective cohort study was conducted utilizing data that was collected through the American College of Surgeon’s National Surgical Quality Improvement Program (NSQIP) Database. All patients that underwent laparoscopic hysterectomy for benign indications were identified. Patients with malnutrition were identified by either low albumin (≤ 3.5 g/dL), low body mass index (≤ 18.5), or 10% weight loss within 6 months. The frequency of postoperative complications was evaluated with univariate and multivariate analyses where appropriate.Results:Following adjustment, multivariate analysis illustrated pre-operative malnutrition to be a risk factor for the following complications: any complication, death, bleeding requiring transfusion, wound, cardiac, pulmonary, renal, thromboembolic, sepsis complications, extended length of stay, and reoperation (p ≤ 0.05 for all).Conclusion:Malnourished patients were at significantly higher risk of developing postoperative complications during the acute postoperative period. With elective laparoscopic hysterectomies, pre-operative evaluation and intervention for malnutrition should be considered to improve nutritional status.

Research paper thumbnail of Cytokine profiling reveals a unique inflammaging signature in human follicular fluid and the ovary

Research paper thumbnail of Impact of insurance coverage for fertility treatment on patient preference for singleton gestation

Research paper thumbnail of Perceptions of multifetal gestation amongst patients being treated for infertility

Research paper thumbnail of Safeguarding Trainee Health: A Call for an Annual Opt-Out Mental Health Screening

American Journal of Psychiatry Residents' Journal