Cerebral involvement with disseminated intravascular coagulation in intestinal disease (original) (raw)

Abstract

Over a two-and-a-half-year period at the Sheffield Royal Infirmary, six patients developed disseminated intravascular coagulation as a serious complication of intestinal disease. There was clinical evidence of cerebral involvement in all six patients, and small vessel thrombi were demonstrated in the brains of all three cases examined post mortem. Where the true significance of the cerebral disorder was not recognised, this led to delay in the diagnosis with serious risk to the patient. In the single case in which the diagnosis was made early, the intravascular coagulation was completely reversed with heparin therapy.

551

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Borda I. T., Southern R. F., Brown W. F. Cerebral venous thrombosis in ulcerative colitis. Gastroenterology. 1973 Jan;64(1):116–119. [PubMed] [Google Scholar]
  2. ELLIS B. C., STRANSKY A. A quick and accurate method for the determination of fibronogen in plasma. J Lab Clin Med. 1961 Sep;58:477–488. [PubMed] [Google Scholar]
  3. HJORT P. F., RAPAPORT S. I. THE SHWARTZMAN REACTION: PATHOGENETIC MECHANISMS AND CLINICAL MANIFESTATIONS. Annu Rev Med. 1965;16:135–168. doi: 10.1146/annurev.me.16.020165.001031. [DOI] [PubMed] [Google Scholar]
  4. Harrison M. J., Truelove S. C. Cerebral venous thrombosis as a complication of ulcerative colitis. Am J Dig Dis. 1967 Oct;12(10):1025–1028. doi: 10.1007/BF02233262. [DOI] [PubMed] [Google Scholar]
  5. Lam A., Borda I. T., Inwood M. J., Thomson S. Coagulation studies in ulcerative colitis and Crohn's disease. Gastroenterology. 1975 Feb;68(2):245–251. [PubMed] [Google Scholar]
  6. Ryan F. P., Preston F. E., Smart R. C., Holdsworth C. D. Proceedings: Abnormalities of splenic function in ulcerative colitis and Crohn's disease. Gut. 1975 Oct;16(10):834–834. [PubMed] [Google Scholar]
  7. Silverstein A., Present D. H. Cerebrovascular occlusions in relatively young patients with regional enteritis. JAMA. 1971 Feb 8;215(6):976–977. [PubMed] [Google Scholar]
  8. Timperley W. R., Preston F. E., Ward J. D. Cerebral intravascular coagulation in diabetic ketoacidosis. Lancet. 1974 May 18;1(7864):952–956. doi: 10.1016/s0140-6736(74)91261-6. [DOI] [PubMed] [Google Scholar]