XGlab Alberti | Politecnico di Milano (original) (raw)

Papers by XGlab Alberti

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007

ABSTRACT

2008 IEEE Nuclear Science Symposium Conference Record, 2008

PIXE (Particle Induced X-ray Emission) is a very powerful technique for the detection of medium-l... more PIXE (Particle Induced X-ray Emission) is a very powerful technique for the detection of medium-light elements (down to Z=11 − Na) due to its superior cross-sections in this atomic number region. However, a common problem in all PIXE setups is the backscattering of protons from the target that perturbs the electronic system, causing front-end electronics saturation, increasing the dead-time and

2006 IEEE Nuclear Science Symposium Conference Record, 2006

This work aims to assess the feasibility of studying the distribution of drugs and diagnostic age... more This work aims to assess the feasibility of studying the distribution of drugs and diagnostic agents in biological specimens by means of XRF detected with high-resolution and high sensitivity Silicon Drift Detectors. In the present study we have employed as diagnostic agent a gadolinium complex (Gadocoletic acid trisodium salt - B22956/1). The primary excitation beam was the light of the SYRMEP beamline of the Elettra synchrotron light source. For calibration purposes we analyzed solutions of the Gd complex in water at different dilutions. The minimum level of Gd detected is 5 mug/ml. We measured the Gd complex distribution in different organs (liver, kidney, spleen, lung) and in blood of mice at different times after a single injection of B22956 (250 mg/Kg body weight) and the Gd complex uptake in human liver-derived cells. This technique will allow the measure of pharmacokinetics and the study of the homogeneity of drug distribution inside organs providing a new tool in the development, follow-up and tracking of drug delivery in vitro.

IEEE Transactions on Nuclear Science, 2015

2008 IEEE Nuclear Science Symposium Conference Record, 2008

In this work we present a recently developed Low Energy X-ray Fluorescence spectrometer (LEXRF) s... more In this work we present a recently developed Low Energy X-ray Fluorescence spectrometer (LEXRF) system combined with a soft and multi-keV X-ray Microscope. The LEXRF setup is a modular system based on the use of multiple large area Silicon Drift Detectors (SDD), with the option of up-scaling it to 8 detectors. The detectors are read-out by a custom designed electronics

X-RAY SPECTROMETRY 44(4) · MAY 2015, May 2015

We present a multi-analytical non-invasive approach for the characterisation of yellow paints use... more We present a multi-analytical non-invasive approach for the characterisation of yellow paints used in three paintings from the International Gallery of Modern Art Cà Pesaro, Venice. The paintings selected for this study were executed in oil-based media between 1940 and 1960, they are unvarnished and have large monochromatic yellow areas. We focus on the identification of yellow pigments with a combined approach based on non-invasive portable X-ray Fluorescence spectrometry, complemented with VIS reflectance, remote-Fourier Transform Infrared and Raman spectroscopies. Different yellow pigments including Chrome yellow Naples Yellow and Cadmium-based yellow were identified. Their identification is of fundamental importance because several modern inorganic yellow pigments (in particular chrome and cadmium-based pigments) are known to exhibit peculiar degradation patterns, leading to noteworthy aesthetic changes in paint such as darkening and fading. This work highlights the suitability of non-destructive techniques for the characterisation of modern paints and the utility of an integrated approach to obtain useful information for preventive conservation. Results demonstrate the need to complement elemental data acquired using portable X-ray Fluorescence with suitable complementary molecular spectroscopic techniques. Copyright © 2015 John Wiley & Sons, Ltd.

A Digital Pulse Processor (DPP) developed for high resolution and ultra-fast X-Ray Spectroscopy i... more A Digital Pulse Processor (DPP) developed for high resolution and ultra-fast X-Ray Spectroscopy is presented. The system is principally suitable for spectrometers based on last generation Silicon Drift Detector (SDD) used in application with high speed elemental mapping.

2008 IEEE Nuclear Science Symposium Conference Record, 2008

We have developed a PIXE (Particle Induced X-ray Emission) spectrometer for light element analysi... more We have developed a PIXE (Particle Induced X-ray Emission) spectrometer for light element analysis based on a Silicon Drift Detector and on a polycapillary lens. The polycapillary lens is needed to guarantee a good solid angle for X-ray detection while minimizing the rate of back-scattered protons impinging on the detector. To this aim we are using a polycapillary lens with

2007 IEEE Nuclear Science Symposium Conference Record, 2007

We have developed a detection module based on a Silicon Drift Detector to assess the feasibility ... more We have developed a detection module based on a Silicon Drift Detector to assess the feasibility of medium light elements (down to Z=11 - Na) detection in PIXE measurements at on of the beam-lines with external proton beam at the Tandetron in LABEC (INFN, Firenze, Italy). The achieved energy resolution is of the order of 134 eV FWHM at Mn

IEEE Nuclear Science Symposium Conference Record, 2005, 2005

An ultra-fast XRF spectrometer based on a novel ring-shaped semiconductor drift detector (SDD) an... more An ultra-fast XRF spectrometer based on a novel ring-shaped semiconductor drift detector (SDD) and on a novel readout and processing electronics is introduced and its performance is discussed. The new detector is based on 4 independent "droplet" type SDDs monolithically integrated on the same chip. The detector shape optimizes the collection angle for the fluorescence radiation. The excitation X-ray beam

Microscopy and Microanalysis, 2014

Journal of Instrumentation, 2014

2011 IEEE Nuclear Science Symposium Conference Record, 2011

We present a monolithic CMOS charge preamplifier named “CUBE”. It is specifically designed to be ... more We present a monolithic CMOS charge preamplifier named “CUBE”. It is specifically designed to be used with Silicon Drift Detectors (SDD). We will show that the use a MOSFET as input transistor allows superior noise performances at very short shaping times respect to the state-of-the-art externally connected JFET devices. We will show the achievable energy resolutions using a 10mm2 reference

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007

ABSTRACT

2008 IEEE Nuclear Science Symposium Conference Record, 2008

PIXE (Particle Induced X-ray Emission) is a very powerful technique for the detection of medium-l... more PIXE (Particle Induced X-ray Emission) is a very powerful technique for the detection of medium-light elements (down to Z=11 − Na) due to its superior cross-sections in this atomic number region. However, a common problem in all PIXE setups is the backscattering of protons from the target that perturbs the electronic system, causing front-end electronics saturation, increasing the dead-time and

2006 IEEE Nuclear Science Symposium Conference Record, 2006

This work aims to assess the feasibility of studying the distribution of drugs and diagnostic age... more This work aims to assess the feasibility of studying the distribution of drugs and diagnostic agents in biological specimens by means of XRF detected with high-resolution and high sensitivity Silicon Drift Detectors. In the present study we have employed as diagnostic agent a gadolinium complex (Gadocoletic acid trisodium salt - B22956/1). The primary excitation beam was the light of the SYRMEP beamline of the Elettra synchrotron light source. For calibration purposes we analyzed solutions of the Gd complex in water at different dilutions. The minimum level of Gd detected is 5 mug/ml. We measured the Gd complex distribution in different organs (liver, kidney, spleen, lung) and in blood of mice at different times after a single injection of B22956 (250 mg/Kg body weight) and the Gd complex uptake in human liver-derived cells. This technique will allow the measure of pharmacokinetics and the study of the homogeneity of drug distribution inside organs providing a new tool in the development, follow-up and tracking of drug delivery in vitro.

IEEE Transactions on Nuclear Science, 2015

2008 IEEE Nuclear Science Symposium Conference Record, 2008

In this work we present a recently developed Low Energy X-ray Fluorescence spectrometer (LEXRF) s... more In this work we present a recently developed Low Energy X-ray Fluorescence spectrometer (LEXRF) system combined with a soft and multi-keV X-ray Microscope. The LEXRF setup is a modular system based on the use of multiple large area Silicon Drift Detectors (SDD), with the option of up-scaling it to 8 detectors. The detectors are read-out by a custom designed electronics

X-RAY SPECTROMETRY 44(4) · MAY 2015, May 2015

We present a multi-analytical non-invasive approach for the characterisation of yellow paints use... more We present a multi-analytical non-invasive approach for the characterisation of yellow paints used in three paintings from the International Gallery of Modern Art Cà Pesaro, Venice. The paintings selected for this study were executed in oil-based media between 1940 and 1960, they are unvarnished and have large monochromatic yellow areas. We focus on the identification of yellow pigments with a combined approach based on non-invasive portable X-ray Fluorescence spectrometry, complemented with VIS reflectance, remote-Fourier Transform Infrared and Raman spectroscopies. Different yellow pigments including Chrome yellow Naples Yellow and Cadmium-based yellow were identified. Their identification is of fundamental importance because several modern inorganic yellow pigments (in particular chrome and cadmium-based pigments) are known to exhibit peculiar degradation patterns, leading to noteworthy aesthetic changes in paint such as darkening and fading. This work highlights the suitability of non-destructive techniques for the characterisation of modern paints and the utility of an integrated approach to obtain useful information for preventive conservation. Results demonstrate the need to complement elemental data acquired using portable X-ray Fluorescence with suitable complementary molecular spectroscopic techniques. Copyright © 2015 John Wiley & Sons, Ltd.

A Digital Pulse Processor (DPP) developed for high resolution and ultra-fast X-Ray Spectroscopy i... more A Digital Pulse Processor (DPP) developed for high resolution and ultra-fast X-Ray Spectroscopy is presented. The system is principally suitable for spectrometers based on last generation Silicon Drift Detector (SDD) used in application with high speed elemental mapping.

2008 IEEE Nuclear Science Symposium Conference Record, 2008

We have developed a PIXE (Particle Induced X-ray Emission) spectrometer for light element analysi... more We have developed a PIXE (Particle Induced X-ray Emission) spectrometer for light element analysis based on a Silicon Drift Detector and on a polycapillary lens. The polycapillary lens is needed to guarantee a good solid angle for X-ray detection while minimizing the rate of back-scattered protons impinging on the detector. To this aim we are using a polycapillary lens with

2007 IEEE Nuclear Science Symposium Conference Record, 2007

We have developed a detection module based on a Silicon Drift Detector to assess the feasibility ... more We have developed a detection module based on a Silicon Drift Detector to assess the feasibility of medium light elements (down to Z=11 - Na) detection in PIXE measurements at on of the beam-lines with external proton beam at the Tandetron in LABEC (INFN, Firenze, Italy). The achieved energy resolution is of the order of 134 eV FWHM at Mn

IEEE Nuclear Science Symposium Conference Record, 2005, 2005

An ultra-fast XRF spectrometer based on a novel ring-shaped semiconductor drift detector (SDD) an... more An ultra-fast XRF spectrometer based on a novel ring-shaped semiconductor drift detector (SDD) and on a novel readout and processing electronics is introduced and its performance is discussed. The new detector is based on 4 independent "droplet" type SDDs monolithically integrated on the same chip. The detector shape optimizes the collection angle for the fluorescence radiation. The excitation X-ray beam

Microscopy and Microanalysis, 2014

Journal of Instrumentation, 2014

2011 IEEE Nuclear Science Symposium Conference Record, 2011

We present a monolithic CMOS charge preamplifier named “CUBE”. It is specifically designed to be ... more We present a monolithic CMOS charge preamplifier named “CUBE”. It is specifically designed to be used with Silicon Drift Detectors (SDD). We will show that the use a MOSFET as input transistor allows superior noise performances at very short shaping times respect to the state-of-the-art externally connected JFET devices. We will show the achievable energy resolutions using a 10mm2 reference