Ching-Hsien Chen • UC Davis Profiles (original) (raw)

  1. Let-7f-5p Has Antifibrotic Properties and Is Reduced in Circulatory Small Extracellular Vesicles in Progressive Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2025 Dec; 211(12):2410-2413. Tan DBA, Stentenbach M, Bolitho E, Tedja C, Aresgado E, Chen CH, Linderholm A, Oldham J, Moodley Y, AIPFR. PMID: 40961262; PMCID: PMC12700245.
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  2. Repurposing flavopiridol as an inhaled therapeutic for pulmonary fibrosis. Eur J Pharmacol. 2025 Oct 15; 1005:178058. Chen CH, Chaudhary SK, Chang WH, Yang DC, Chang SY, Xu J, Hsu SW, Yik JH, Liu GY, Haudenschild DR. PMID: 40816528; PMCID: PMC12479379.
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    Translation:HumansAnimalsCells
  3. Proteomic Biomarkers of Survival in Non-Idiopathic Pulmonary Fibrosis Interstitial Lung Disease. Am J Respir Crit Care Med. 2025 Aug; 211(8):1452-1462. Alqalyoobi S, Smith JA, Maddali MV, Pugashetti JV, Newton CA, Kim JS, Linderholm AL, Chen CH, Ma SF, Bose S, Murray S, Adegunsoye A, Strek ME, Garcia CK, Wolters PJ, Martinez FJ, Noth I, Oldham JM. PMID: 40208180; PMCID: PMC12369864.
    View in: PubMed Mentions: 6 Fields:
    Translation:Humans
  4. Protocol for a patient-derived preclinical platform to model tumor-immune interactions and evaluate therapeutic efficacy. STAR Protoc. 2025 Mar 21; 6(1):103623. Chang WH, Chin AI, Chen CH. PMID: 39918963; PMCID: PMC11848467.
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    Translation:HumansCells
  5. Biological Age, Chronological Age, and Survival in Pulmonary Fibrosis: A Causal Mediation Analysis. Am J Respir Crit Care Med. 2024 Sep 01; 210(5):639-647. Pugashetti JV, Kim JS, Bose S, Adegunsoye A, Linderholm AL, Chen CH, Strek ME, Flaherty KR, Murray S, Newton CA, Alqalyoobi S, Ma SF, Mychaleckyj JC, Bowler RP, Han MK, Curtis JL, Martinez FJ, Smith JA, Noth I, Oldham JM. PMID: 38843133; PMCID: PMC11389564.
    View in: PubMed Mentions: 6 Fields:
    Translation:Humans
  6. Molecular Endotypes of Idiopathic Pulmonary Fibrosis: A Latent Class Analysis of Two Multicenter Observational Cohorts. Am J Respir Crit Care Med. 2024 Aug 15; 210(4):455-464. Maddali MV, Moore AR, Sinha P, Newton CA, Kim JS, Adegunsoye A, Ma SF, Strek ME, Chen CH, Linderholm AL, Zemans RL, Moore BB, Wolters PJ, Martinez FJ, Rogers AJ, Raj R, Noth I, Oldham JM. PMID: 38913573; PMCID: PMC11351813.
    View in: PubMed Mentions: 10 Fields:
    Translation:Humans
  7. Inhibition of MARCKS phosphorylation attenuates of dendritic cell migration in a murine model of acute asthma. Eur J Pharmacol. 2024 Oct 05; 980:176867. Lee CC, Chen CH, Kenyon NJ, Wang CN, Tsai HC, Chiu CL, Chen Y, Forteza RM, Wu R. PMID: 39111683.
    View in: PubMed Mentions: 2 Fields:
    Translation:HumansAnimalsCells
  8. Single-Cell Spatial Transcriptomics Unveils Platelet-Fueled Cycling Macrophages for Kidney Fibrosis. Adv Sci (Weinh). 2024 08; 11(29):e2308505. Liu J, Zheng B, Cui Q, Zhu Y, Chu L, Geng Z, Mao Y, Wan L, Cao X, Xiong Q, Guo F, Yang DC, Hsu SW, Chen CH, Yan X. PMID: 38838052; PMCID: PMC11304276.
    View in: PubMed Mentions: 10 Fields:
    Translation:AnimalsCells
  9. A multidimensional classifier to support lung transplant referral in patients with pulmonary fibrosis. J Heart Lung Transplant. 2024 07; 43(7):1174-1182. Pugashetti JV, Kim JS, Combs MP, Ma SF, Adegunsoye A, Linderholm AL, Strek ME, Chen CH, Dilling DF, Whelan TPM, Flaherty KR, Martinez FJ, Noth I, Oldham JM. PMID: 38556070; PMCID: PMC11451110.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  10. Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis. Redox Rep. 2023 Dec; 28(1):2152607. Dong XQ, Chu LK, Cao X, Xiong QW, Mao YM, Chen CH, Bi YL, Liu J, Yan XM. PMID: 36692085; PMCID: PMC9879199.
    View in: PubMed Mentions: 23 Fields:
    Translation:Animals
  11. Spatial Decoding of Immune Cell Contribution to Fibroblastic Foci in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023 09 15; 208(6):728-731. Yang DC, Hsu SW, Li JM, Oldham J, Chen CH. PMID: 37487177; PMCID: PMC10515576.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansCells
  12. Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis. Respir Res. 2023 May 16; 24(1):132. Li JM, Chang WH, Li L, Yang DC, Hsu SW, Kenyon NJ, Chen CH. PMID: 37194070; PMCID: PMC10189934.
    View in: PubMed Mentions: 7 Fields:
    Translation:AnimalsCells
  13. Associations of Long-Term Physical Activity Trajectories With All-Cause Mortality in a General Population. Int J Public Health. 2023; 68:1605332. Lee CL, Liu WJ, Chen CH, Wang JS. PMID: 36726527; PMCID: PMC9884672.
    View in: PubMed Mentions: 3 Fields:
    Translation:Humans
  14. MTAP deficiency contributes to immune landscape remodelling and tumour evasion. Immunology. 2023 02; 168(2):331-345. Chang WH, Hsu SW, Zhang J, Li JM, Yang DD, Chu CW, Yoo EE, Zhang W, Yu SL, Chen CH. PMID: 36183155; PMCID: PMC9840685.
    View in: PubMed Mentions: 10 Fields:
    Translation:HumansAnimalsCells
  15. The Role of MARCKS in Metastasis and Treatment Resistance of Solid Tumors. Cancers (Basel). 2022 Oct 08; 14(19). Chiu CL, Zhao H, Chen CH, Wu R, Brooks JD. PMID: 36230850; PMCID: PMC9563266.
    View in: PubMed Mentions: 10
  16. Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP-deficient lung cancer. EMBO Rep. 2022 08 03; 23(8):e54265. Chang WH, Chen YJ, Hsiao YJ, Chiang CC, Wang CY, Chang YL, Hong QS, Lin CY, Lin SU, Chang GC, Chen HY, Chen YJ, Chen CH, Yang PC, Yu SL. PMID: 35766227; PMCID: PMC9346486.
    View in: PubMed Mentions: 13 Fields:
    Translation:Humans
  17. A Novel Renoprotective Strategy: Upregulation of PD-L1 Mitigates Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2021 Dec 10; 22(24). Liu J, Yang DC, Zhang J, Hsu SW, Weiss RH, Chen CH. PMID: 34948109; PMCID: PMC8706395.
    View in: PubMed Mentions: 5 Fields:
    Translation:AnimalsCells
  18. Targeting the AXL Receptor in Combating Smoking-related Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2021 06; 64(6):734-746. Yang DC, Gu S, Li JM, Hsu SW, Chen SJ, Chang WH, Chen CH. PMID: 33730527; PMCID: PMC8456879.
    View in: PubMed Mentions: 14 Fields:
    Translation:HumansAnimalsCells
  19. L-arginine as a potential GLP-1-mediated immunomodulator of Th17-related cytokines in people with obesity and asthma. Obes Sci Pract. 2021 Jun; 7(3):339-345. Liao SY, Linderholm A, Showalter MR, Chen CH, Fiehn O, Kenyon NJ. PMID: 34123401; PMCID: PMC8170586.
    View in: PubMed Mentions: 7
  20. MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer. Theranostics. 2021; 11(9):4122-4136. Liu J, Chen SJ, Hsu SW, Zhang J, Li JM, Yang DC, Gu S, Pinkerton KE, Chen CH. PMID: 33754052; PMCID: PMC7977464.
    View in: PubMed Mentions: 24 Fields:
    Translation:HumansAnimalsCells
  21. Therapeutic targeting of argininosuccinate synthase 1 (ASS1)-deficient pulmonary fibrosis. Mol Ther. 2021 04 07; 29(4):1487-1500. Li JM, Yang DC, Oldham J, Linderholm A, Zhang J, Liu J, Kenyon NJ, Chen CH. PMID: 33508432; PMCID: PMC8058484.
    View in: PubMed Mentions: 24 Fields:
    Translation:HumansAnimalsCells
  22. Metabolic reprogramming: A driver of cigarette smoke-induced inflammatory lung diseases. Free Radic Biol Med. 2021 02 01; 163:392-401. Li L, Yang DC, Chen CH. PMID: 33387604; PMCID: PMC7870291.
    View in: PubMed Mentions: 19 Fields:
    Translation:HumansAnimals
  23. Potential New Therapeutic Approaches for Renal Cell Carcinoma. Semin Nephrol. 2020 01; 40(1):86-97. Yang DC, Chen CH. PMID: 32130970.
    View in: PubMed Mentions: 25 Fields:
    Translation:Humans
  24. Approximate Mortality Risks between Hyperuricemia and Diabetes in the United States. J Clin Med. 2019 Dec 03; 8(12). Chen PH, Chen YW, Liu WJ, Hsu SW, Chen CH, Lee CL. PMID: 31816820; PMCID: PMC6947281.
    View in: PubMed Mentions: 12
  25. Tackling MARCKS-PIP3 circuit attenuates fibroblast activation and fibrosis progression. FASEB J. 2019 12; 33(12):14354-14369. Yang DC, Li JM, Xu J, Oldham J, Phan SH, Last JA, Wu R, Chen CH. PMID: 31661644; PMCID: PMC6894092.
    View in: PubMed Mentions: 14 Fields:
    Translation:HumansAnimalsCells
  26. Targeting the phosphorylation site of myristoylated alanine-rich C kinase substrate alleviates symptoms in a murine model of steroid-resistant asthma. Br J Pharmacol. 2019 04; 176(8):1122-1134. Wang CN, Lin YC, Chang BC, Chen CH, Wu R, Lee CC. PMID: 30706455; PMCID: PMC6451065.
    View in: PubMed Mentions: 10 Fields:
    Translation:AnimalsCells
  27. Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma. Signal Transduct Target Ther. 2019; 4:2. Xu J, Chang WH, Fong LWR, Weiss RH, Yu SL, Chen CH. PMID: 30701095; PMCID: PMC6345872.
    View in: PubMed Mentions: 17 Fields:
  28. Cigarette Smoking-Mediated Macrophage Reprogramming: Mechanistic Insights and Therapeutic Implications. J Nat Sci. 2018 Nov; 4(11). Yang DC, Chen CH. PMID: 30801020; PMCID: PMC6383770.
    View in: PubMed Mentions: 22
  29. An oxidation-resistant, recombinant alpha-1 antitrypsin produced in Nicotiana benthamiana. Free Radic Biol Med. 2018 05 20; 120:303-310. Silberstein DZ, Karuppanan K, Aung HH, Chen CH, Cross CE, McDonald KA. PMID: 29551638; PMCID: PMC6093210.
    View in: PubMed Mentions: 9 Fields:
    Translation:HumansAnimalsCells
  30. Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers. Cancer Metastasis Rev. 2017 Dec; 36(4):737-747. Fong LWR, Yang DC, Chen CH. PMID: 29039083.
    View in: PubMed Mentions: 42 Fields:
    Translation:HumansAnimals
  31. Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction. Int J Mol Sci. 2017 Nov 10; 18(11). Chang WH, Thai P, Xu J, Yang DC, Wu R, Chen CH. PMID: 29125538; PMCID: PMC5713355.
    View in: PubMed Mentions: 7 Fields:
    Translation:HumansCells
  32. GHetting to know ADPKD proliferative signaling, STAT. Kidney Int. 2017 03; 91(3):524-526. Chen CH, Weiss RH. PMID: 28202165.
    View in: PubMed Mentions: 2 Fields:
    Translation:HumansCells
  33. Upregulation of MARCKS in kidney cancer and its potential as a therapeutic target. Oncogene. 2017 06 22; 36(25):3588-3598. Chen CH, Fong LWR, Yu E, Wu R, Trott JF, Weiss RH. PMID: 28166200; PMCID: PMC5926797.
    View in: PubMed Mentions: 29 Fields:
    Translation:HumansAnimalsCells
  34. Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. Oncotarget. 2016 10 11; 7(41):66540-66557. Trott JF, Kim J, Abu Aboud O, Wettersten H, Stewart B, Berryhill G, Uzal F, Hovey RC, Chen CH, Anderson K, Graef A, Sarver AL, Modiano JF, Weiss RH. PMID: 27572319; PMCID: PMC5341819.
    View in: PubMed Mentions: 36 Fields:
    Translation:HumansAnimalsCells
  35. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth. Mol Cancer Ther. 2016 09; 15(9):2119-29. Abu Aboud O, Chen CH, Senapedis W, Baloglu E, Argueta C, Weiss RH. PMID: 27390344; PMCID: PMC5010932.
    View in: PubMed Mentions: 78 Fields:
    Translation:HumansAnimalsCells
  36. HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. Oncogene. 2016 10 27; 35(43):5674-5685. Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL. PMID: 27065329.
    View in: PubMed Mentions: 23 Fields:
    Translation:HumansAnimalsCells
  37. Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment. Oncotarget. 2015 Jun 20; 6(17):15194-208. Chen CH, Cheng CT, Yuan Y, Zhai J, Arif M, Fong LW, Wu R, Ann DK. PMID: 26015406; PMCID: PMC4558145.
    View in: PubMed Mentions: 29 Fields:
    Translation:HumansAnimalsCells
  38. IIIDB: a database for isoform-isoform interactions and isoform network modules. BMC Genomics. 2015; 16 Suppl 2:S10. Tseng YT, Li W, Chen CH, Zhang S, Chen JJ, Zhou X, Liu CC. PMID: 25707505; PMCID: PMC4331710.
    View in: PubMed Mentions: 16 Fields:
    Translation:HumansCells
  39. Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1127-38. Chen CH, Statt S, Chiu CL, Thai P, Arif M, Adler KB, Wu R. PMID: 25318062; PMCID: PMC4299640.
    View in: PubMed Mentions: 44 Fields:
    Translation:HumansAnimalsCells
  40. Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):433-44. Chen CC, Chen HY, Su KY, Hong QS, Yan BS, Chen CH, Pan SH, Chang YL, Wang CJ, Hung PF, Yuan S, Chang GC, Chen JJ, Yang PC, Yang YC, Yu SL. PMID: 25036006.
    View in: PubMed Mentions: 28 Fields:
    Translation:HumansAnimalsCells
  41. A novel predictor of cancer malignancy: up-regulation of myristoylated alanine-rich C kinase substrate phosphorylation in lung cancer. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1002-4. Chen CH, Chiu CL, Adler KB, Wu R. PMID: 24735036; PMCID: PMC4098099.
    View in: PubMed Mentions: 13 Fields:
    Translation:HumansCells
  42. A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis. Oncogene. 2014 Jul 10; 33(28):3696-706. Chen CH, Thai P, Yoneda K, Adler KB, Yang PC, Wu R. PMID: 23955080; PMCID: PMC4631387.
    View in: PubMed Mentions: 50 Fields:
    Translation:HumansAnimalsCells
  43. Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):204-11. Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R. PMID: 23672216; PMCID: PMC3824039.
    View in: PubMed Mentions: 135 Fields:
    Translation:HumansCellsCTClinical Trials
  44. Deletion of ATG5 shows a role of autophagy in salivary homeostatic control. J Dent Res. 2013 Oct; 92(10):911-7. Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH. PMID: 23884556; PMCID: PMC3775371.
    View in: PubMed Mentions: 24 Fields:
    Translation:AnimalsCells
  45. A novel function of YWHAZ/β-catenin axis in promoting epithelial-mesenchymal transition and lung cancer metastasis. Mol Cancer Res. 2012 Oct; 10(10):1319-31. Chen CH, Chuang SM, Yang MF, Liao JW, Yu SL, Chen JJ. PMID: 22912335.
    View in: PubMed Mentions: 63 Fields:
    Translation:HumansAnimalsCells
  46. Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain. BMC Microbiol. 2011 Mar 08; 11:50. Lin YC, Lu MC, Tang HL, Liu HC, Chen CH, Liu KS, Lin C, Chiou CS, Chiang MK, Chen CM, Lai YC. PMID: 21385400; PMCID: PMC3060850.
    View in: PubMed Mentions: 69 Fields:
    Translation:HumansAnimalsCells
  47. Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells. Exp Cell Res. 2010 Oct 15; 316(17):2910-21. Chen CH, Lin H, Chuang SM, Lin SY, Chen JJ. PMID: 20615403.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansCells
  48. Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol Cancer Ther. 2008 Nov; 7(11):3527-38. Lee CY, Sher HF, Chen HW, Liu CC, Chen CH, Lin CS, Yang PC, Tsay HS, Chen JJ. PMID: 19001436.
    View in: PubMed Mentions: 50 Fields:
    Translation:HumansAnimalsCells

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