Thomas Ambrosi • UC Davis Profiles (original) (raw)

  1. Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens. Nat Nanotechnol. 2026 Jan 21. Zhao L, O'Donnell KL, Dubey M, Wang Y, Martinez NR, Zhang Y, Steininger HM, Ma C, Mallajosyula V, Lee LLY, Lachmansingh RN, Stavitsky S, Takematsu E, Hoover MY, Chen H, Guo J, Wu A, Ma Y, Wang X, Nalin AP, Jeong SD, Lu WJ, Nguyen PK, Clancy CS, Tal MC, Xiao J, Longaker MT, Lee AS, Kim BYS, Ambrosi TH, Weissman IL, Davis MM, Hasenkrug KJ, Chien YH, Jiang W, Marzi A, Chan CKF. PMID: 41565781.
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  2. Characterization of human skeletal stem cells in closed and open tibia fractures: a single center pilot study. Front Physiol. 2025; 16:1638064. Tresgallo-Parés R, Morales D, Tse S, Saade A, Fitzpatrick E, Campbell ST, Soles GL, Ambrosi TH, Lee MA, Saiz AM. PMID: 41103294; PMCID: PMC12521247.
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  3. Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis. Nat Commun. 2025 Aug 15; 16(1):7606. Ambrosi TH, Morales D, Chen K, Hunt EJ, Weldon KC, Maifeld AN, Chavez FIM, Wang Y, Zhao L, Wang L, Murphy MP, Cressman A, Wheeler EE, Saiz AM, Leach JK, Fierro FA, Chan CKF, Lane NE. PMID: 40817087; PMCID: PMC12356905.
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    Translation:HumansAnimalsCells
  4. Modulating immune-stem cell crosstalk enables robust bone regeneration via tuning compositions of macroporous scaffolds. NPJ Regen Med. 2025 Jul 01; 10(1):33. Su N, Saqib H, Villicana C, Kim S, Ambrosi TH, Freeman P, Kim T, Tong X, Ayushman M, Chan CKF, Yang F. PMID: 40595820; PMCID: PMC12219738.
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  5. Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites. Cell Stem Cell. 2025 May 01; 32(5):811-823.e11. Ambrosi TH, Taheri S, Chen K, Sinha R, Wang Y, Hunt EJ, Goodnough LH, Murphy MP, Steininger HM, Hoover MY, Felix F, Weldon KC, Koepke LS, Sokol J, Liu DD, Zhao L, Conley SD, Lu WJ, Morri M, Neff NF, Van Rysselberghe NL, Wheeler EE, Wang Y, Leach JK, Saiz A, Wang A, Yang GP, Goodman S, Bishop JA, Gardner MJ, Wan DC, Weissman IL, Longaker MT, Sahoo D, Chan CKF. PMID: 40118065; PMCID: PMC12048286.
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    Translation:HumansCells
  6. Harnessing the diversity and potential of endogenous skeletal stem cells for musculoskeletal tissue regeneration. Stem Cells. 2025 Mar 10; 43(3). Weldon KC, Longaker MT, Ambrosi TH. PMID: 39945760; PMCID: PMC11892563.
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    Translation:HumansAnimalsCells
  7. Surveying the landscape of emerging osteoanabolic therapies. Nat Rev Endocrinol. 2025 Feb; 21(2):75-76. Ambrosi TH. PMID: 39653789.
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  8. A maternal brain hormone that builds bone. Nature. 2024 Aug; 632(8024):357-365. Babey ME, Krause WC, Chen K, Herber CB, Torok Z, Nikkanen J, Rodriguez R, Zhang X, Castro-Navarro F, Wang Y, Wheeler EE, Villeda S, Leach JK, Lane NE, Scheller EL, Chan CKF, Ambrosi TH, Ingraham HA. PMID: 38987585; PMCID: PMC11306098.
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    Translation:HumansAnimalsCells
  9. Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females. bioRxiv. 2023 Nov 16. Babey ME, Krause WC, Herber CB, Chen K, Nikkanen J, Rodriquez R, Zhang X, Castro-Navarro F, Wang Y, Villeda S, Lane NE, Scheller EL, Chan CKF, Ambrosi TH, Ingraham HA. PMID: 37693376; PMCID: PMC10491109.
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  10. Purification and functional characterization of novel human skeletal stem cell lineages. Nat Protoc. 2023 07; 18(7):2256-2282. Hoover MY, Ambrosi TH, Steininger HM, Koepke LS, Wang Y, Zhao L, Murphy MP, Alam AA, Arouge EJ, Butler MGK, Takematsu E, Stavitsky SP, Hu S, Sahoo D, Sinha R, Morri M, Neff N, Bishop J, Gardner M, Goodman S, Longaker M, Chan CKF. PMID: 37316563; PMCID: PMC10495180.
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    Translation:HumansAnimalsCells
  11. Optimizing Delivery of Therapeutic Growth Factors for Bone and Cartilage Regeneration. Gels. 2023 May 03; 9(5). Takematsu E, Murphy M, Hou S, Steininger H, Alam A, Ambrosi TH, Chan CKF. PMID: 37232969; PMCID: PMC10217467.
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  12. A Combination of Distinct Vascular Stem/Progenitor Cells for Neovascularization and Ischemic Rescue. Arterioscler Thromb Vasc Biol. 2023 07; 43(7):1262-1277. Zhao L, Lee AS, Sasagawa K, Sokol J, Wang Y, Ransom RC, Zhao X, Ma C, Steininger HM, Koepke LS, Borrelli MR, Brewer RE, Lee LLY, Huang X, Ambrosi TH, Sinha R, Hoover MY, Seita J, Weissman IL, Wu JC, Wan DC, Xiao J, Longaker MT, Nguyen PK, Chan CKF. PMID: 37051932; PMCID: PMC10281192.
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    Translation:HumansAnimalsCells
  13. A seed-and-soil theory for blood ageing. Nat Cell Biol. 2023 01; 25(1):9-11. Ambrosi TH, Chan CKF. PMID: 36650380; PMCID: PMC10611483.
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  14. Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration. Nat Commun. 2022 10 30; 13(1):6491. Andrew TW, Koepke LS, Wang Y, Lopez M, Steininger H, Struck D, Boyko T, Ambrosi TH, Tong X, Sun Y, Gulati GS, Murphy MP, Marecic O, Tevlin R, Schallmoser K, Strunk D, Seita J, Goodman SB, Yang F, Longaker MT, Yang GP, Chan CKF. PMID: 36310174; PMCID: PMC9618571.
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    Translation:HumansAnimalsCells
  15. Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs. Front Endocrinol (Lausanne). 2022; 13:924927. Goodnough LH, Ambrosi TH, Steininger HM, Butler MGK, Hoover MY, Choo H, Van Rysselberghe NL, Bellino MJ, Bishop JA, Gardner MJ, Chan CKF. PMID: 36093067; PMCID: PMC9454294.
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    Translation:HumansAnimalsCells
  16. Aging of Skeletal Stem Cells. Adv Geriatr Med Res. 2022; 4(2). Butler MGK, Ambrosi TH, Murphy MP, Chan CKF. PMID: 36037035; PMCID: PMC9409336.
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  17. Aged skeletal stem cells generate an inflammatory degenerative niche. Nature. 2021 09; 597(7875):256-262. Ambrosi TH, Marecic O, McArdle A, Sinha R, Gulati GS, Tong X, Wang Y, Steininger HM, Hoover MY, Koepke LS, Murphy MP, Sokol J, Seo EY, Tevlin R, Lopez M, Brewer RE, Mascharak S, Lu L, Ajanaku O, Conley SD, Seita J, Morri M, Neff NF, Sahoo D, Yang F, Weissman IL, Longaker MT, Chan CKF. PMID: 34381212; PMCID: PMC8721524.
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    Translation:AnimalsCells
  18. Distinct skeletal stem cell types orchestrate long bone skeletogenesis. Elife. 2021 07 19; 10. Ambrosi TH, Sinha R, Steininger HM, Hoover MY, Murphy MP, Koepke LS, Wang Y, Lu WJ, Morri M, Neff NF, Weissman IL, Longaker MT, Chan CK. PMID: 34280086; PMCID: PMC8289409.
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    Translation:AnimalsCells
  19. Skeletal Stem Cells as the Developmental Origin of Cellular Niches for Hematopoietic Stem and Progenitor Cells. Curr Top Microbiol Immunol. 2021; 434:1-31. Ambrosi TH, Chan CKF. PMID: 34850280; PMCID: PMC8864730.
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    Translation:Cells
  20. Human skeletal stem cell aging. Aging (Albany NY). 2020 Sep 14; 12(17):16669-16671. Ambrosi TH, Goodnough LH, Chan CKF. PMID: 32929053; PMCID: PMC7521487.
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  21. Delayed Union of a Diaphyseal Forearm Fracture Associated With Impaired Osteogenic Differentiation of Prospectively Isolated Human Skeletal Stem Cells. JBMR Plus. 2020 Oct; 4(10):e10398. Goodnough LH, Ambrosi TH, Steininger H, DeBaun MR, Abrams GD, McAdams TR, Gardner MJ, Chan CK, Bishop JA. PMID: 33103027; PMCID: PMC7574703.
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  22. Articular cartilage regeneration by activated skeletal stem cells. Nat Med. 2020 10; 26(10):1583-1592. Murphy MP, Koepke LS, Lopez MT, Tong X, Ambrosi TH, Gulati GS, Marecic O, Wang Y, Ransom RC, Hoover MY, Steininger H, Zhao L, Walkiewicz MP, Quarto N, Levi B, Wan DC, Weissman IL, Goodman SB, Yang F, Longaker MT, Chan CKF. PMID: 32807933; PMCID: PMC7704061.
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    Translation:HumansAnimalsCells
  23. Geriatric fragility fractures are associated with a human skeletal stem cell defect. Aging Cell. 2020 07; 19(7):e13164. Ambrosi TH, Goodnough LH, Steininger HM, Hoover MY, Kim E, Koepke LS, Marecic O, Zhao L, Seita J, Bishop JA, Gardner MJ, Chan CKF. PMID: 32537886; PMCID: PMC7370785.
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    Translation:HumansCells
  24. FGF21, not GCN2, influences bone morphology due to dietary protein restrictions. Bone Rep. 2020 Jun; 12:100241. McNulty MA, Goupil BA, Albarado DC, Castaño-Martinez T, Ambrosi TH, Puh S, Schulz TJ, Schürmann A, Morrison CD, Laeger T. PMID: 31921941; PMCID: PMC6950640.
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  25. A Revised Perspective of Skeletal Stem Cell Biology. Front Cell Dev Biol. 2019; 7:189. Ambrosi TH, Longaker MT, Chan CKF. PMID: 31572721; PMCID: PMC6753172.
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  26. Identification of the Human Skeletal Stem Cell. Cell. 2018 09 20; 175(1):43-56.e21. Chan CKF, Gulati GS, Sinha R, Tompkins JV, Lopez M, Carter AC, Ransom RC, Reinisch A, Wearda T, Murphy M, Brewer RE, Koepke LS, Marecic O, Manjunath A, Seo EY, Leavitt T, Lu WJ, Nguyen A, Conley SD, Salhotra A, Ambrosi TH, Borrelli MR, Siebel T, Chan K, Schallmoser K, Seita J, Sahoo D, Goodnough H, Bishop J, Gardner M, Majeti R, Wan DC, Goodman S, Weissman IL, Chang HY, Longaker MT. PMID: 30241615; PMCID: PMC6400492.
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    Translation:HumansAnimalsCells
  27. Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism. Aging Cell. 2018 Oct; 17(5):e12810. Graja A, Garcia-Carrizo F, Jank AM, Gohlke S, Ambrosi TH, Jonas W, Ussar S, Kern M, Schürmann A, Aleksandrova K, Blüher M, Schulz TJ. PMID: 30088333; PMCID: PMC6156450.
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    Translation:HumansAnimalsCells
  28. Loss of the Hematopoietic Stem Cell Factor GATA2 in the Osteogenic Lineage Impairs Trabecularization and Mechanical Strength of Bone. Mol Cell Biol. 2018 06 15; 38(12). Tolkachov A, Fischer C, Ambrosi TH, Bothe M, Han CT, Muenzner M, Mathia S, Salminen M, Seifert G, Thiele M, Duda GN, Meijsing SH, Sauer S, Schulz TJ, Schupp M. PMID: 29581184; PMCID: PMC5974429.
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    Translation:AnimalsCells
  29. The emerging role of bone marrow adipose tissue in bone health and dysfunction. J Mol Med (Berl). 2017 Dec; 95(12):1291-1301. Ambrosi TH, Schulz TJ. PMID: 29101431.
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    Translation:HumansAnimals
  30. Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration. Cell Stem Cell. 2017 06 01; 20(6):771-784.e6. Ambrosi TH, Scialdone A, Graja A, Gohlke S, Jank AM, Bocian C, Woelk L, Fan H, Logan DW, Schürmann A, Saraiva LR, Schulz TJ. PMID: 28330582; PMCID: PMC5459794.
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    Translation:AnimalsCells
  31. Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action. Mol Metab. 2016 Feb; 5(2):79-90. Ost M, Coleman V, Voigt A, van Schothorst EM, Keipert S, van der Stelt I, Ringel S, Graja A, Ambrosi T, Kipp AP, Jastroch M, Schulz TJ, Keijer J, Klaus S. PMID: 26909316; PMCID: PMC4735627.
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  32. A Focused Low-Intensity Pulsed Ultrasound (FLIPUS) System for Cell Stimulation: Physical and Biological Proof of Principle. IEEE Trans Ultrason Ferroelectr Freq Control. 2016 Jan; 63(1):91-100. Puts R, Ruschke K, Ambrosi TH, Kadow-Romacker A, Knaus P, Jenderka KV, Raum K. PMID: 26552085.
    View in: PubMed Mentions: 4 Fields:
    Translation:AnimalsCells

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