Jessica Rexach • UCLA Profiles (original) (raw)

1. Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer's disease. bioRxiv. 2026 Apr 01. Pereira FL, Lew C, Li SH, Rizzi L, Soloviev AV, Paes V, Brooks SD, Spina S, Rexach JE, Newell KL, Leite REP, Seeley WW, Suemoto CK, Ghetti B, Murray ME, Grinberg LT. PMID: 41959086; PMCID: PMC13060171.
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2. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. Cell. 2026 Mar 05; 189(5):1517-1534.e19. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Bose RS, Travaglini KJ, Lam VL, Goodness D, Ta T, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan HS, Carroll EC, Lawrence RE, Gestwicki JE, Rexach JE, Eisenberg DS, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. PMID: 41610849; PMCID: PMC12978015.
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3. Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain. Cell Rep Med. 2026 Jan 20; 7(1):102535. Chaubey K, Vázquez-Rosa E, Tripathi SJ, Shin MK, Yu Y, Dhar M, Chakraborty S, Yamakawa M, Wang X, Sridharan PS, Miller E, Bud Z, Corella SG, Barker S, Caradonna SG, Koh Y, Franke K, Cintrón-Pérez CJ, Rose S, Fang H, Cintrón-Pérez AA, Tomco T, Zhu X, Fujioka H, Gefen T, Flanagan ME, Williams NS, Wilson BM, Chen L, Dou L, Cheng F, Rexach JE, Woo JA, Kang DE, Paul BD, Pieper AA. PMID: 41435831; PMCID: PMC12866132.
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   Translation:HumansAnimalsCells
4. An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS. bioRxiv. 2025 Aug 25. Gautier O, Blum JA, Nguyen TP, Klemm S, Yamakawa M, Sinnott-Armstrong N, Zeng Y, Davis CO, Bombosch J, Nakayama L, Guttenplan KA, Chen D, Kathira A, Zhao L, Rexach JE, Greenleaf WJ, Gitler AD. PMID: 40909710; PMCID: PMC12407787.
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5. BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults. Alzheimers Dement (N Y). 2025 Apr-Jun; 11(2):e70106. Cadwallader CJ, VandeBunte AM, Fischer DL, Chen C, Diaz VE, Lee SY, Chan B, Lario-Lago A, Rojas JC, Ramos EM, Rexach JE, Yokoyama JS, Kramer JH, Paolillo EW, Saloner R, Casaletto KB. PMID: 40547329; PMCID: PMC12178939.
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6. Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states. bioRxiv. 2025 Jun 04. Han X, Zhang T, Lee CY, Ravi A, Spina S, Li AN, Grinberg LT, Seeley WW, Huckins LM, Raj T, Brennand KJ, Rexach JE. PMID: 40502140; PMCID: PMC12157633.
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7. Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference. Alzheimers Dement. 2025 Jan; 21(1):e14291. Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang YA, Jackvony S, Lai L, Guen YL, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MG, Wilcock DM. PMID: 39692624; PMCID: PMC11772715.
   View in: PubMed Mentions: 4 Fields:
   Translation:HumansAnimals
8. Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics. Cell. 2024 Oct 03; 187(20):5753-5774.e28. Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Han X, Yamakawa M, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH. PMID: 39265576; PMCID: PMC12017262.
   View in: PubMed Mentions: 10 Fields:
   Translation:HumansCells
9. CSF Proteomics in Patients With Progressive Supranuclear Palsy. Neurology. 2024 Aug 13; 103(3):e209585. Wise A, Li J, Yamakawa M, Loureiro J, Peterson B, Worringer K, Sivasankaran R, Palma JA, Mitic L, Heuer HW, Lario-Lago A, Staffaroni AM, Clark A, Taylor J, Ljubenkov PA, Vandevrede L, Grinberg LT, Spina S, Seeley WW, Miller BL, Boeve BF, Dickerson BC, Grossman M, Litvan I, Pantelyat A, Tartaglia MC, Zhang Z, Wills AA, Rexach J, Rojas JC, Boxer AL, as the 4-Repeat Tauopathy Neuroimaging Initiative. PMID: 38959435; PMCID: PMC11226322.
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   Translation:Humans
10. Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study. JMIR Aging. 2024 Jun 26; 7:e52831. Paolillo EW, Casaletto KB, Clark AL, Taylor JC, Heuer HW, Wise AB, Dhanam S, Sanderson-Cimino M, Saloner R, Kramer JH, Kornak J, Kremers W, Forsberg L, Appleby B, Bayram E, Bozoki A, Brushaber D, Darby RR, Day GS, Dickerson BC, Domoto-Reilly K, Elahi F, Fields JA, Ghoshal N, Graff-Radford N, G H Hall M, Honig LS, Huey ED, Lapid MI, Litvan I, Mackenzie IR, Masdeu JC, Mendez MF, Mester C, Miyagawa T, Naasan G, Pascual B, Pressman P, Ramos EM, Rankin KP, Rexach J, Rojas JC, VandeVrede L, Wong B, Wszolek ZK, Boeve BF, Rosen HJ, Boxer AL, Staffaroni AM, ALLFTD Consortium. PMID: 38922667; PMCID: PMC11237775.
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    Translation:Humans
11. Pharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimer's disease. Alzheimers Dement. 2024 08; 20(8):5236-5246. Morales J, Gabriel N, Natarajan L, LaCroix AZ, Shadyab AH, Xu R, Silverman J, Feldman HH, Hernandez I, Powder for Pennies Collaboration. PMID: 39030734; PMCID: PMC11350022.
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    Translation:Humans
12. Loss of TBC1D2B causes a progressive neurological disorder with gingival overgrowth. Eur J Hum Genet. 2024 May; 32(5):558-566. Harms FL, Rexach JE, Efthymiou S, Aynekin B, Per H, Güleç A, Nampoothiri S, Sampaio H, Sachdev R, Stoeva R, Myers K, Pena LDM, Kalfa TA, Chard M, Klassen M, Pries M, Kutsche K. PMID: 38374468; PMCID: PMC11061173.
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    Translation:Humans
13. Cell States and Interactions of CD8 T Cells and Disease-Enriched Microglia in Human Brains with Alzheimer's Disease. Biomedicines. 2024 Jan 29; 12(2). Yamakawa M, Rexach JE. PMID: 38397909; PMCID: PMC10886701.
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14. Novel avenues of tau research. Alzheimers Dement. 2024 03; 20(3):2240-2261. Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC. PMID: 38170841; PMCID: PMC10984447.
    View in: PubMed Mentions: 8 Fields:
    Translation:Humans
15. Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics. bioRxiv. 2023 Sep 30. Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH. PMID: 37808727; PMCID: PMC10557766.
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16. Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults. Alzheimers Dement. 2023 08; 19(8):3448-3457. Saloner R, Paolillo EW, Wojta KJ, Fonseca C, Gontrum EQ, Lario-Lago A, Rabinovici GD, Yokoyama JS, Rexach JE, Kramer JH, Casaletto KB. PMID: 36807763; PMCID: PMC10435666.
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    Translation:Humans
17. Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system. Front Immunol. 2022; 13:1056417. Houser MC, Uriarte Huarte O, Wallings RL, Keating CE, MacPherson KP, Herrick MK, Kannarkat GT, Kelly SD, Chang J, Varvel NH, Rexach JE, Tansey MG. PMID: 36618392; PMCID: PMC9814971.
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    Translation:AnimalsCells
18. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 06 25; 12(1):3958. Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. PMID: 34172753; PMCID: PMC8233314.
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    Translation:HumansAnimalsCells
19. C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron. 2021 07 21; 109(14):2275-2291.e8. Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. PMID: 34133945; PMCID: PMC8298293.
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    Translation:AnimalsCells
20. Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression. Cell Rep. 2020 11 17; 33(7):108398. Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, Trojanowski JQ, Malhotra D, Geschwind DH. PMID: 33207193; PMCID: PMC7842189.
    View in: PubMed Mentions: 55 Fields:
    Translation:HumansAnimalsCells
21. Sex-related differences in the relationship between β-amyloid and cognitive trajectories in older adults. Neuropsychology. 2020 Nov; 34(8):835-850. Lindbergh CA, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Edwards L, Tsoy E, Elahi F, Walters SM, Cotter D, You M, Apple AC, Asken B, Neuhaus J, Rexach JE, Wojta KJ, Rabinovici G, Kramer JH, Hillblom Aging Network. PMID: 33030915; PMCID: PMC7839841.
    View in: PubMed Mentions: 8 Fields:
    Translation:Humans
22. Selective Neuronal Vulnerability in Alzheimer's Disease: A Modern Holy Grail. Neuron. 2020 09 09; 107(5):763-765. Rexach J, Geschwind D. PMID: 32910887.
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    Translation:HumansCells
23. Emotional detachment, gait ataxia, and cerebellar dysconnectivity associated with compound heterozygous mutations in the SPG7 gene. Neurocase. 2020 10; 26(5):299-304. Ringman JM, Qiao Y, Garbin A, Fisher BE, Fogel B, Watari Knoell K, Chui HC, Shi Y, Rexach JE. PMID: 32893728; PMCID: PMC7530119.
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    Translation:Humans
24. The Neurodevelopmental and Motor Phenotype of SCA21 (ATX-TMEM240). J Child Neurol. 2020 12; 35(14):953-962. Burdekin ED, Fogel BL, Jeste SS, Martinez J, Rexach JE, DiStefano C, Hyde C, Safari T, Wilson RB. PMID: 32705938; PMCID: PMC7674185.
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    Translation:Humans
25. A diagnostic ceiling for exome sequencing in cerebellar ataxia and related neurological disorders. Hum Mutat. 2020 02; 41(2):487-501. Ngo KJ, Rexach JE, Lee H, Petty LE, Perlman S, Valera JM, Deignan JL, Mao Y, Aker M, Posey JE, Jhangiani SN, Coban-Akdemir ZH, Boerwinkle E, Muzny D, Nelson AB, Hassin-Baer S, Poke G, Neas K, Geschwind MD, Grody WW, Gibbs R, Geschwind DH, Lupski JR, Below JE, Nelson SF, Fogel BL. PMID: 31692161; PMCID: PMC7182470.
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    Translation:HumansCells
26. A family with spinocerebellar ataxia and retinitis pigmentosa attributed to an ELOVL4 mutation. Neurol Genet. 2019 10; 5(5):e357. Xiao C, Binkley EM, Rexach J, Knight-Johnson A, Khemani P, Fogel BL, Das S, Stone EM, Gomez CM. PMID: 31750392; PMCID: PMC6812731.
    View in: PubMed Mentions: 19
27. Clinical application of next-generation sequencing to the practice of neurology. Lancet Neurol. 2019 05; 18(5):492-503. Rexach J, Lee H, Martinez-Agosto JA, Németh AH, Fogel BL. PMID: 30981321; PMCID: PMC7055532.
    View in: PubMed Mentions: 47 Fields:
    Translation:Humans
28. Next generation sequencing in clinical diagnosis. Lancet Neurol. 2019 May; 18(5):426. Lee H, Martinez-Agosto JA, Rexach J, Fogel BL. PMID: 30981320.
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29. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nat Med. 2019 01; 25(1):152-164. Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH. PMID: 30510257; PMCID: PMC6602064.
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    Translation:HumansAnimalsCells
30. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):15120-15125. Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC. PMID: 27956640; PMCID: PMC5206508.
    View in: PubMed Mentions: 115 Fields:
    Translation:HumansAnimalsCells
31. A Case of Spinocerebellar Ataxia With a Reversible Splenium Lesion Due to Malnutrition and Vitamin Deficiency. J Clin Neuromuscul Dis. 2015 Dec; 17(2):95-7. Trikamji B, Rexach J, Mishra SK. PMID: 26583499.
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    Translation:Humans
32. Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags. Curr Protoc Chem Biol. 2013; 5(4):281-302. Clark PM, Rexach JE, Hsieh-Wilson LC. PMID: 24391098; PMCID: PMC3931299.
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    Translation:HumansAnimalsCells
33. Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation. Nat Chem Biol. 2012 Jan 22; 8(3):253-61. Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC. PMID: 22267118; PMCID: PMC3288555.
    View in: PubMed Mentions: 130 Fields:
    Translation:AnimalsCells
34. Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags. Nat Chem Biol. 2010 Sep; 6(9):645-51. Rexach JE, Rogers CJ, Yu SH, Tao J, Sun YE, Hsieh-Wilson LC. PMID: 20657584; PMCID: PMC2924450.
    View in: PubMed Mentions: 101 Fields:
    Translation:Cells
35. Chemical approaches to understanding O-GlcNAc glycosylation in the brain. Nat Chem Biol. 2008 Feb; 4(2):97-106. Rexach JE, Clark PM, Hsieh-Wilson LC. PMID: 18202679; PMCID: PMC3250351.
    View in: PubMed Mentions: 68 Fields:
    Translation:HumansAnimalsCells
36. Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics. Nat Chem Biol. 2007 Jun; 3(6):339-48. Khidekel N, Ficarro SB, Clark PM, Bryan MC, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC. PMID: 17496889.
    View in: PubMed Mentions: 183 Fields:
    Translation:AnimalsCells
37. The Chlamydomonas reinhardtii Nar1 gene encodes a chloroplast membrane protein involved in nitrite transport. Plant Cell. 2000 Aug; 12(8):1441-53. Rexach J, Fernández E, Galván A. PMID: 10948261; PMCID: PMC149114.
    View in: PubMed Mentions: 25 Fields:
    Translation:AnimalsCells

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