Benjamin Zaepfel • UCSD Profiles (original) (raw)

  1. 5-ethynyluridine perturbs nuclear RNA metabolism to promote the nuclear accumulation of TDP-43 and other RNA binding proteins. bioRxiv. 2025 Apr 03. Hayes LR, Zaepfel B, Duan L, Starner AC, Bartels MD, Rothacher RL, Martin S, French R, Zhang Z, Sinha IR, Ling JP, Sun S, Ayala YM, Coller J, Van Nostrand EL, Florea L, Kalab P. PMID: 40236187; PMCID: PMC11996483.
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  2. A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model. Acta Neuropathol Commun. 2024 12 26; 12(1):203. Thompson EG, Spead O, Akerman SC, Curcio C, Zaepfel BL, Kent ER, Philips T, Vijayakumar BG, Zacco A, Zhou W, Nagappan G, Rothstein JD. PMID: 39722074; PMCID: PMC11670477.
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    Translation:HumansAnimalsCells
  3. A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV- C9ORF72 (G 4 C 2) 66 mouse model. Res Sq. 2024 Dec 10. Thompson EG, Spead O, Akerman SC, Curcio C, Zaepfel BL, Kent ER, Philips T, Vijayakumar BG, Zacco A, Zhou W, Nagappan G, Rothstein JD. PMID: 39711523; PMCID: PMC11661372.
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  4. A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV-C9ORF72 (G4C2)66 mouse model. bioRxiv. 2024 Aug 27. Thompson EG, Spead O, Akerman SC, Curcio C, Zaepfel BL, Kent ER, Philips T, Vijayakumar BG, Zacco A, Zhou W, Nagappan G, Rothstein JD. PMID: 39253499; PMCID: PMC11383318.
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  5. Counter-regulation of RNA stability by UPF1 and TDP43. bioRxiv. 2024 Feb 15. Gomez N, Hsieh C, Li X, Dykstra M, Waksmacki J, Altheim C, Bechar Y, Klim J, Zaepfel B, Rothstein J, Tank EE, Barmada SJ. PMID: 38352350; PMCID: PMC10862862.
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  6. Nuclear Pore Dysfunction in Neurodegeneration. Neurotherapeutics. 2022 07; 19(4):1050-1060. Spead O, Zaepfel BL, Rothstein JD. PMID: 36070178; PMCID: PMC9587172.
    View in: PubMed Mentions: 19 Fields:
    Translation:HumansCells
  7. Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export. Cell Rep. 2022 07 19; 40(3):111106. Duan L, Zaepfel BL, Aksenova V, Dasso M, Rothstein JD, Kalab P, Hayes LR. PMID: 35858577; PMCID: PMC9345261.
    View in: PubMed Mentions: 37 Fields:
    Translation:HumansCells
  8. Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress. Front Cell Dev Biol. 2021; 9:809859. Zaepfel BL, Rothstein JD. PMID: 34970554; PMCID: PMC8712688.
    View in: PubMed Mentions: 1
  9. Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. Sci Transl Med. 2021 07 28; 13(604). Coyne AN, Baskerville V, Zaepfel BL, Dickson DW, Rigo F, Bennett F, Lusk CP, Rothstein JD. PMID: 34321318; PMCID: PMC9022198.
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    Translation:HumansCells
  10. RNA Is a Double-Edged Sword in ALS Pathogenesis. Front Cell Neurosci. 2021; 15:708181. Zaepfel BL, Rothstein JD. PMID: 34349625; PMCID: PMC8326408.
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  11. UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction. Cell Rep. 2021 03 30; 34(13):108925. Zaepfel BL, Zhang Z, Maulding K, Coyne AN, Cheng W, Hayes LR, Lloyd TE, Sun S, Rothstein JD. PMID: 33789100; PMCID: PMC8063722.
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    Translation:HumansAnimalsCells
  12. G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron. 2020 09 23; 107(6):1124-1140.e11. Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. PMID: 32673563; PMCID: PMC8077944.
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    Translation:HumansCells
  13. Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. Cell Rep. 2017 Oct 03; 21(1):110-125. Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC. PMID: 28978466; PMCID: PMC5679478.
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    Translation:HumansAnimalsCells
  14. Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS. Front Cell Neurosci. 2017; 11:243. Coyne AN, Zaepfel BL, Zarnescu DC. PMID: 28860970; PMCID: PMC5562674.
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  15. Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Hum Mol Genet. 2015 Dec 15; 24(24):6886-98. Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, Zarnescu DC. PMID: 26385636; PMCID: PMC5007633.
    View in: PubMed Mentions: 53 Fields:
    Translation:HumansAnimalsCells

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This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.

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