Varykina Thackray • UCSD Profiles (original) (raw)

  1. Toll-like Receptor 4 Contributes to PCOS-like Metabolic and Reproductive Pathogenesis. bioRxiv. 2025 Oct 17. Wiggins K, Del Mundo Z, Angulo JA, Naidu N, Saba A, Garcia C, Nguyen C, Ujagar N, De La Torre JJ, De Robles G, Rivera A, Trinh D, Tinoco R, Kauffman AS, Thackray VG, Agrawal A, Seldin M, Sanchez GP, Nicholas D. PMID: 41279684; PMCID: PMC12632965.
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  2. A Point Mutation in an Otherwise Dispensable Upstream Fshb Enhancer Moderately Impairs Fertility in Female Mice. Endocrinology. 2025 Apr 22; 166(6). Bohaczuk SC, Tonsfeldt KJ, Slaiwa TI, Dunn GA, Gillette DLM, Yeo SE, Shi C, Cassin J, Thackray VG, Mellon PL. PMID: 40237337; PMCID: PMC12038155.
    View in: PubMed Mentions: Fields:
    Translation:AnimalsCells
  3. T cells are necessary for development of PCOS reproductive symptoms in a letrozole-induced mouse model of PCOS. bioRxiv. 2025 Jan 13. Ujagar N, Velez LM, De Robles G, Nguyen C, Wiggins K, Kim J, Naidu N, Angulo JA, Kauffman AS, Thackray VG, Banaszewska B, Wysocka E, Duleba A, Seldin M, Nicholas D. PMID: 39868135; PMCID: PMC11760259.
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  4. Genetic hypogonadal (Gnrh1hpg) mouse model uncovers influence of reproductive axis on maturation of the gut microbiome during puberty. bioRxiv. 2024 Jul 02. Sisk-Hackworth L, Akhavan SR, Krutkin DD, Kelley ST, Thackray VG. PMID: 39005422; PMCID: PMC11245025.
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  5. Harnessing the power within: engineering the microbiome for enhanced gynecologic health. Reprod Fertil. 2024 04 01; 5(2). Brennan C, Chan K, Kumar T, Maissy E, Brubaker L, Dothard MI, Gilbert JA, Gilbert KE, Lewis AL, Thackray VG, Zarrinpar A, Knight R. PMID: 38513356; PMCID: PMC11046331.
    View in: PubMed Mentions: 9 Fields:
    Translation:HumansAnimals
  6. Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities. Biol Sex Differ. 2023 11 06; 14(1):79. Sisk-Hackworth L, Brown J, Sau L, Levine AA, Tam LYI, Ramesh A, Shah RS, Kelley-Thackray ET, Wang S, Nguyen A, Kelley ST, Thackray VG. PMID: 37932822; PMCID: PMC10626657.
    View in: PubMed Mentions: 6 Fields:
    Translation:HumansAnimalsCells
  7. Metabolic dysregulation and gut dysbiosis linked to hyperandrogenism in female mice. Endocrinol Diabetes Metab. 2024 Jan; 7(1):e443. Chen A, Handzel A, Sau L, Cui L, Kelley ST, Thackray VG. PMID: 37872876; PMCID: PMC10782063.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansAnimals
  8. Metagenome-Assembled Genomes from Murine Fecal Microbiomes Dominated by Uncharacterized Bacteria. Microbiol Resour Announc. 2023 Mar 16; 12(3):e0116222. Rastegar K, Kelley ST, Thackray VG. PMID: 36779794; PMCID: PMC10019230.
    View in: PubMed Mentions: 1
  9. Sex, puberty, and the gut microbiome. Reproduction. 2023 02 01; 165(2):R61-R74. Sisk-Hackworth L, Kelley ST, Thackray VG. PMID: 36445259; PMCID: PMC9847487.
    View in: PubMed Mentions: 24 Fields:
    Translation:Humans
  10. Gut Metabolites Are More Predictive of Disease and Cohoused States than Gut Bacterial Features in a Polycystic Ovary Syndrome-Like Mouse Model. mSystems. 2021 Oct 26; 6(5):e0114920. Ho B, Ryback D, Benson B, Mason CN, Torres PJ, Quinn RA, Thackray VG, Kelley ST. PMID: 34519532; PMCID: PMC8547464.
    View in: PubMed Mentions: 11 Fields:
  11. Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB. Endocrinology. 2021 07 01; 162(7). Bohaczuk SC, Cassin J, Slaiwa TI, Thackray VG, Mellon PL. PMID: 33824966; PMCID: PMC8157479.
    View in: PubMed Mentions: 7 Fields:
  12. Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes. Mol Cell Endocrinol. 2021 06 15; 530:111286. Ryan GE, Bohaczuk SC, Cassin J, Witham EA, Shojaei S, Ho EV, Thackray VG, Mellon PL. PMID: 33872733; PMCID: PMC8177864.
    View in: PubMed Mentions: 7 Fields:
    Translation:AnimalsCells
  13. FSHB Transcription is Regulated by a Novel 5' Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism. Endocrinology. 2021 01 01; 162(1). Bohaczuk SC, Thackray VG, Shen J, Skowronska-Krawczyk D, Mellon PL. PMID: 33009549; PMCID: PMC7846141.
    View in: PubMed Mentions: 13 Fields:
    Translation:HumansAnimalsCells
  14. Intersection of Polycystic Ovary Syndrome and the Gut Microbiome. J Endocr Soc. 2021 Feb 01; 5(2):bvaa177. Rizk MG, Thackray VG. PMID: 33381671; PMCID: PMC7757431.
    View in: PubMed Mentions: 44
  15. Alterations in Gut Microbiota Do Not Play a Causal Role in Diet-independent Weight Gain Caused by Ovariectomy. J Endocr Soc. 2021 Jan 01; 5(1):bvaa173. Sau L, Olmstead CM, Cui LJ, Chen A, Shah RS, Kelley ST, Thackray VG. PMID: 33324864; PMCID: PMC7724750.
    View in: PubMed Mentions: 7
  16. Hyperactive LH Pulses and Elevated Kisspeptin and NKB Gene Expression in the Arcuate Nucleus of a PCOS Mouse Model. Endocrinology. 2020 04 01; 161(4). Esparza LA, Schafer D, Ho BS, Thackray VG, Kauffman AS. PMID: 32031594; PMCID: PMC7341557.
    View in: PubMed Mentions: 40 Fields:
    Translation:AnimalsCells
  17. Insulin-induced hypoglycaemia suppresses pulsatile luteinising hormone secretion and arcuate Kiss1 cell activation in female mice. J Neuroendocrinol. 2019 12; 31(12):e12813. McCosh RB, Kreisman MJ, Tian K, Ho BS, Thackray VG, Breen KM. PMID: 31758872; PMCID: PMC6933080.
    View in: PubMed Mentions: 13 Fields:
    Translation:AnimalsCells
  18. Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome. PLoS One. 2019; 14(9):e0223274. Arroyo P, Ho BS, Sau L, Kelley ST, Thackray VG. PMID: 31568518; PMCID: PMC6768472.
    View in: PubMed Mentions: 35 Fields:
    Translation:HumansAnimals
  19. Age- and Sex-Dependent Patterns of Gut Microbial Diversity in Human Adults. mSystems. 2019 Jul-Aug; 4(4). de la Cuesta-Zuluaga J, Kelley ST, Chen Y, Escobar JS, Mueller NT, Ley RE, McDonald D, Huang S, Swafford AD, Knight R, Thackray VG. PMID: 31098397; PMCID: PMC6517691.
    View in: PubMed Mentions: 215 Fields:
  20. Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model. Endocrinology. 2019 05 01; 160(5):1193-1204. Torres PJ, Ho BS, Arroyo P, Sau L, Chen A, Kelley ST, Thackray VG. PMID: 30924862; PMCID: PMC6482036.
    View in: PubMed Mentions: 51 Fields:
    Translation:HumansAnimals
  21. Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice. BMC Microbiol. 2019 03 12; 19(1):57. Torres PJ, Skarra DV, Ho BS, Sau L, Anvar AR, Kelley ST, Thackray VG. PMID: 30871463; PMCID: PMC6419356.
    View in: PubMed Mentions: 25 Fields:
    Translation:Animals
  22. Sex, Microbes, and Polycystic Ovary Syndrome. Trends Endocrinol Metab. 2019 01; 30(1):54-65. Thackray VG. PMID: 30503354; PMCID: PMC6309599.
    View in: PubMed Mentions: 94 Fields:
    Translation:Humans
  23. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May-Jun; 3(3). McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, Aksenov AA, Behsaz B, Brennan C, Chen Y, DeRight Goldasich L, Dorrestein PC, Dunn RR, Fahimipour AK, Gaffney J, Gilbert JA, Gogul G, Green JL, Hugenholtz P, Humphrey G, Huttenhower C, Jackson MA, Janssen S, Jeste DV, Jiang L, Kelley ST, Knights D, Kosciolek T, Ladau J, Leach J, Marotz C, Meleshko D, Melnik AV, Metcalf JL, Mohimani H, Montassier E, Navas-Molina J, Nguyen TT, Peddada S, Pevzner P, Pollard KS, Rahnavard G, Robbins-Pianka A, Sangwan N, Shorenstein J, Smarr L, Song SJ, Spector T, Swafford AD, Thackray VG, Thompson LR, Tripathi A, Vázquez-Baeza Y, Vrbanac A, Wischmeyer P, Wolfe E, Zhu Q, American Gut Consortium , Knight R. PMID: 29795809; PMCID: PMC5954204.
    View in: PubMed Mentions: 465 Fields:
  24. Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism. J Clin Endocrinol Metab. 2018 04 01; 103(4):1502-1511. Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, Thackray VG. PMID: 29370410; PMCID: PMC6276580.
    View in: PubMed Mentions: 196 Fields:
    Translation:Humans
  25. Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance. Endocrinology. 2017 09 01; 158(9):2988-3003. Skarra DV, Hernández-Carretero A, Rivera AJ, Anvar AR, Thackray VG. PMID: 28911175; PMCID: PMC5659661.
    View in: PubMed Mentions: 25 Fields:
    Translation:Animals
  26. The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. PLoS One. 2016; 11(1):e0146509. Kelley ST, Skarra DV, Rivera AJ, Thackray VG. PMID: 26731268; PMCID: PMC4701222.
    View in: PubMed Mentions: 99 Fields:
    Translation:Animals
  27. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. PMID: 26203175; PMCID: PMC4710190.
    View in: PubMed Mentions: 105 Fields:
    Translation:Animals
  28. FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes. Mol Cell Endocrinol. 2015 Apr 15; 405:14-24. Skarra DV, Thackray VG. PMID: 25676570; PMCID: PMC4363278.
    View in: PubMed Mentions: 4 Fields:
    Translation:AnimalsCells
  29. Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. PLoS One. 2014; 9(11):e113839. Park CH, Skarra DV, Rivera AJ, Arriola DJ, Thackray VG. PMID: 25423188; PMCID: PMC4244159.
    View in: PubMed Mentions: 5 Fields:
    Translation:AnimalsCells
  30. Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):62-70. Thackray VG. PMID: 24099863; PMCID: PMC3947687.
    View in: PubMed Mentions: 15 Fields:
    Translation:HumansAnimalsCells
  31. Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes. Mol Endocrinol. 2013 Nov; 27(11):1825-39. Skarra DV, Arriola DJ, Benson CA, Thackray VG. PMID: 24065703; PMCID: PMC3805845.
    View in: PubMed Mentions: 11 Fields:
    Translation:HumansAnimalsCells
  32. A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription. Endocrinology. 2013 Sep; 154(9):3016-21. Benson CA, Kurz TL, Thackray VG. PMID: 23766128; PMCID: PMC3749480.
    View in: PubMed Mentions: 17 Fields:
    Translation:HumansAnimalsCells
  33. FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells. J Biol Chem. 2012 Sep 28; 287(40):33424-35. Arriola DJ, Mayo SL, Skarra DV, Benson CA, Thackray VG. PMID: 22865884; PMCID: PMC3460444.
    View in: PubMed Mentions: 21 Fields:
    Translation:HumansAnimalsCells
  34. Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. Breen KM, Thackray VG, Hsu T, Mak-McCully RA, Coss D, Mellon PL. PMID: 22851703; PMCID: PMC3458227.
    View in: PubMed Mentions: 26 Fields:
    Translation:AnimalsCells
  35. FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter. Endocrinology. 2012 Apr; 153(4):2023-33. Ghochani Y, Saini JK, Mellon PL, Thackray VG. PMID: 22294749; PMCID: PMC3320250.
    View in: PubMed Mentions: 14 Fields:
    Translation:AnimalsCells
  36. A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab. 2010 Sep; 21(9):562-8. Coss D, Mellon PL, Thackray VG. PMID: 20598900; PMCID: PMC2933269.
    View in: PubMed Mentions: 23 Fields:
    Translation:HumansAnimalsCells
  37. Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. Breen KM, Thackray VG, Coss D, Mellon PL. PMID: 20357224; PMCID: PMC2875819.
    View in: PubMed Mentions: 10 Fields:
    Translation:AnimalsCells
  38. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010 Jan 27; 314(2):192-203. Thackray VG, Mellon PL, Coss D. PMID: 19747958; PMCID: PMC2815122.
    View in: PubMed Mentions: 68 Fields:
    Translation:HumansAnimalsCells
  39. Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology. 2009 May; 150(5):2395-403. Thackray VG, Hunnicutt JL, Memon AK, Ghochani Y, Mellon PL. PMID: 19106225; PMCID: PMC2671912.
    View in: PubMed Mentions: 13 Fields:
    Translation:HumansAnimalsCells
  40. Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology. 2008 Jul; 149(7):3643-55. Sasson R, Luu SH, Thackray VG, Mellon PL. PMID: 18403486; PMCID: PMC2453092.
    View in: PubMed Mentions: 8 Fields:
    Translation:HumansCells
  41. Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008 Mar; 149(3):1091-102. Thackray VG, Mellon PL. PMID: 18079204; PMCID: PMC2275352.
    View in: PubMed Mentions: 21 Fields:
    Translation:AnimalsCells
  42. Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology. 2007 Feb; 148(2):762-73. McGillivray SM, Thackray VG, Coss D, Mellon PL. PMID: 17082263; PMCID: PMC2932480.
    View in: PubMed Mentions: 30 Fields:
    Translation:AnimalsCells
  43. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006 Sep; 20(9):2062-79. Thackray VG, McGillivray SM, Mellon PL. PMID: 16675544; PMCID: PMC2941439.
    View in: PubMed Mentions: 35 Fields:
    Translation:HumansAnimalsCells
  44. Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol. 2005 Oct; 19(10):2610-23. Coss D, Thackray VG, Deng CX, Mellon PL. PMID: 15961509; PMCID: PMC2932483.
    View in: PubMed Mentions: 36 Fields:
    Translation:AnimalsCells
  45. Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004 Apr; 18(4):925-40. Spady TJ, Shayya R, Thackray VG, Ehrensberger L, Bailey JS, Mellon PL. PMID: 14701939; PMCID: PMC2932479.
    View in: PubMed Mentions: 24 Fields:
    Translation:HumansAnimalsCells
  46. Novel activation step required for transcriptional competence of progesterone receptor on chromatin templates. Mol Endocrinol. 2003 Dec; 17(12):2543-53. Thackray VG, Toft DO, Nordeen SK. PMID: 14551264.
    View in: PubMed Mentions: 7 Fields:
    Translation:HumansAnimalsCells
  47. High-yield purification of functional, full-length steroid receptor coactivator 1 expressed in insect cells. Biotechniques. 2002 Feb; 32(2):260, 262-3. Thackray VG, Nordeen SK. PMID: 11848398.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansAnimalsCells
  48. Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor. Mol Endocrinol. 2001 Jan; 15(1):17-31. Wan Y, Coxe KK, Thackray VG, Housley PR, Nordeen SK. PMID: 11145736.
    View in: PubMed Mentions: 8 Fields:
    Translation:AnimalsCells
  49. Estrogen agonist and antagonist action on the human estrogen receptor in Drosophila. Endocrinology. 2000 Oct; 141(10):3912-5. Thackray VG, Young RH, Hooper JE, Nordeen SK. PMID: 11014249.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansAnimals
  50. Phylogenetic analyses reveal ancient duplication of estrogen receptor isoforms. J Mol Evol. 1999 Nov; 49(5):609-14. Kelley ST, Thackray VG. PMID: 10552042.
    View in: PubMed Mentions: 9 Fields:
    Translation:HumansAnimals
  51. Differential gene induction by glucocorticoid and progesterone receptors. J Steroid Biochem Mol Biol. 1998 Aug; 66(4):171-8. Thackray VG, Lieberman BA, Nordeen SK. PMID: 9744514.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansAnimalsCells

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