Shashi Pratap Singh | Pranveer Singh Institute Of Technology (original) (raw)
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Papers by Shashi Pratap Singh
Indian Journal of Medical Sciences, 2013
Ipomoea aquatica (I. aquatica) (Convolvulaceae) is commonly grown green leafy vegetable found thr... more Ipomoea aquatica (I. aquatica) (Convolvulaceae) is commonly grown green leafy vegetable found throughout India, Ceylon, Tropical Asia, Africa, and Australia. Traditionally, I. aquatica used as carminative agent and lessens inflammation, and is useful in fever, jaundice, biliousness, bronchitis, liver complaints, etc., I. aquatica is a rich source of vitamins, minerals, proteins, fibers, carotenes, and flavanoids with many health benefits. The objective of this review is to highlight the pharmacognostical, phytochemical, and pharmacological information of this plant.
Pharmaceutical and Biological Evaluations, 2016
Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in... more Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis, the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. The lesions of atherosclerosis occur principally in large and medium-sized elastic and muscular arteries and can lead to ischemia of the heart, brain, or extremities, resulting in infarction. They may be present throughout a person’s lifetime. Among patients with established cardiovascular disease, mortality is lower among those who participate in an exercise program than among those who do not. Furthermore, recent studies have reported positive lipid-lowering effects from estrogen and/or progestogen in postmenopausal women but there are still conflicting reports on the use of these agents in dyslipidae...
Rheumatoid arthritis (RA) is characterized by joint inflammation and swelling, rheumatoid factor ... more Rheumatoid arthritis (RA) is characterized by joint inflammation and swelling, rheumatoid factor (RF) and anticitrullinated protein antibody (ACPA) production, and bone and cartilage destruction. Drug Trend Report spending on rheumatologics grew 69 percent in the pediatric population in 2004, indicating that children are treated with biotech drugs at an increasing rate Recent studies indicate that early and aggressive therapy, including the use of specialty biotech drugs, can improve outcomes for children with JRA Patients with RA ultimately require DMARD therapy but adequate analgesia is also important. Paracetamol remains the analgesic of choice given its excellent safety profile and is prescribed in regular divided doses to a maximum of 4 g/day. Alone, however, it may provide. Tofacitinib (formerly tasocitinib) was recommended for approval by the Arthritis Advisory Committee to the FDA in May 2012. If approved, this will be the first RA treatment in a new class of medications kno...
Pharmaceutical and Biological Evaluations, 2018
The endocrine system is the group of glands that secrete hormone directly into the circulatory sy... more The endocrine system is the group of glands that secrete hormone directly into the circulatory system moves towards distant target organs and affects them. This system release hormones that help control many important body functions. Dysfunctioning in the endocrine system may develop many disorders like diabetes, thyroid, growth disorders and sexual dysfunction. Poly cystic ovarian syndrome is one of the common endocrine disorder. PCOS is a common condition that causes a range of symptoms including irregular periods, unwanted hair growth, acne and weight problems. Increased circulating levels of testosterone can be considered as the major cause of development of polycystic ovarian syndrome. It is a male hormone, but women’s bodies make it too. Higher than normal testosterone level, makes women to experience PCOS. The physicians target on regular menstruation. In order to maintain the regular periods physicians basically administer Estrogen and Progesterone injection. Metformin is us...
Current Trends in Pharmacy and Pharmaceutical Chemistry, 2022
Arsenic is a pollutant in the environment, and its poisoning of drinking water is considered a se... more Arsenic is a pollutant in the environment, and its poisoning of drinking water is considered a severe global health issue. Chronic arsenic exposure is linked to an increased risk of a variety of diseases, including cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. Furthermore, arsenic exposure has been linked to changes in liver function and the development of hepatotoxicity. Furthermore, only a few studies have shown that persistent exposure to arsenic causes carcinogenesis, particularly cancers of the skin, bladder, and lungs. The current study looks at a variety of processes that play a role in arsenic-induced toxicity and end-organ damage.
Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in... more Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis, the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. The lesions of atherosclerosis occur principally in large and medium-sized elastic and muscular arteries and can lead to ischemia of the heart, brain, or extremities, resulting in infarction. They may be present throughout a person's lifetime. Among patients with established cardiovascular disease, mortality is lower among those who participate in an exercise program than among those who do not. Furthermore, recent studies have reported positive lipid-lowering effects from estrogen and/or progestogen in postmenopausal women but there are still conflicting reports on the use of these agents in dyslipi...
Elemental or metallic silver (Ag) is a very malleable and ductile transition metal that is white ... more Elemental or metallic silver (Ag) is a very malleable and ductile transition metal that is white metallic luster appearance. Nanoparticles are fine particles that have size nano-meter in range, that have dimension less than 100 nm (1nm-100nm). As their nano sized they have special physiochemical properties. Silver nano-particles (AgNPs) are one of most widely used nano-material that are used in personal care products, dressings as treatments for external wounds, ointments, and surgical instruments because of their effective antibacterial activity. AgNPs have broad spectrum antibacterial action that acts on both gram-negative and grampositive bacteria both, including antibiotic-resistant strains. AgNPs (diameter 5-20 nm, average diameter ~10 nm) also exhibit the antiviral property against HIV-1, hepatitis B virus, respiratory syncytial virus, herpes simplex virus type 1, and monkey pox virus. AgNPs as well as nano silver-derived solution and their product have showed the potent anti-inflammatory properties. As the consumption of nano-silver products are increasing, the chances of adverse effect on human health and environment are increasing. Generally AgNPs are less toxic than silver ion, but here are several in vitro in vivo studies shown that on exposure of AgNPs leads to cytotoxicity, immunotoxicity and genotoxicity to vertebrates. AgNPs causes blood diseases and colon cancer when it has been found in the blood and colon of patients respectively. kim et al 2008. Reported than 28 oral exposures of AgNPs at 30 mg/kg, 300 mg/kg and 1000 mg/kg in sprague dawley rats show dose dependent distribution of AgNPs in various organs and gender specific two fold more accumulation in female kidneys in comparison to male kidney. Usually the in vivo studies, in vitro studies with AgNPs showed that shown genotoxic effects, induction of DNA strand breaks, micronuclei, and chromosomal aberrationsat low non-cytotoxic doses in different types of human and mammalian cells.
Indian Journal of Medical Sciences, 2013
Ipomoea aquatica (I. aquatica) (Convolvulaceae) is commonly grown green leafy vegetable found thr... more Ipomoea aquatica (I. aquatica) (Convolvulaceae) is commonly grown green leafy vegetable found throughout India, Ceylon, Tropical Asia, Africa, and Australia. Traditionally, I. aquatica used as carminative agent and lessens inflammation, and is useful in fever, jaundice, biliousness, bronchitis, liver complaints, etc., I. aquatica is a rich source of vitamins, minerals, proteins, fibers, carotenes, and flavanoids with many health benefits. The objective of this review is to highlight the pharmacognostical, phytochemical, and pharmacological information of this plant.
Pharmaceutical and Biological Evaluations, 2016
Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in... more Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis, the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. The lesions of atherosclerosis occur principally in large and medium-sized elastic and muscular arteries and can lead to ischemia of the heart, brain, or extremities, resulting in infarction. They may be present throughout a person’s lifetime. Among patients with established cardiovascular disease, mortality is lower among those who participate in an exercise program than among those who do not. Furthermore, recent studies have reported positive lipid-lowering effects from estrogen and/or progestogen in postmenopausal women but there are still conflicting reports on the use of these agents in dyslipidae...
Rheumatoid arthritis (RA) is characterized by joint inflammation and swelling, rheumatoid factor ... more Rheumatoid arthritis (RA) is characterized by joint inflammation and swelling, rheumatoid factor (RF) and anticitrullinated protein antibody (ACPA) production, and bone and cartilage destruction. Drug Trend Report spending on rheumatologics grew 69 percent in the pediatric population in 2004, indicating that children are treated with biotech drugs at an increasing rate Recent studies indicate that early and aggressive therapy, including the use of specialty biotech drugs, can improve outcomes for children with JRA Patients with RA ultimately require DMARD therapy but adequate analgesia is also important. Paracetamol remains the analgesic of choice given its excellent safety profile and is prescribed in regular divided doses to a maximum of 4 g/day. Alone, however, it may provide. Tofacitinib (formerly tasocitinib) was recommended for approval by the Arthritis Advisory Committee to the FDA in May 2012. If approved, this will be the first RA treatment in a new class of medications kno...
Pharmaceutical and Biological Evaluations, 2018
The endocrine system is the group of glands that secrete hormone directly into the circulatory sy... more The endocrine system is the group of glands that secrete hormone directly into the circulatory system moves towards distant target organs and affects them. This system release hormones that help control many important body functions. Dysfunctioning in the endocrine system may develop many disorders like diabetes, thyroid, growth disorders and sexual dysfunction. Poly cystic ovarian syndrome is one of the common endocrine disorder. PCOS is a common condition that causes a range of symptoms including irregular periods, unwanted hair growth, acne and weight problems. Increased circulating levels of testosterone can be considered as the major cause of development of polycystic ovarian syndrome. It is a male hormone, but women’s bodies make it too. Higher than normal testosterone level, makes women to experience PCOS. The physicians target on regular menstruation. In order to maintain the regular periods physicians basically administer Estrogen and Progesterone injection. Metformin is us...
Current Trends in Pharmacy and Pharmaceutical Chemistry, 2022
Arsenic is a pollutant in the environment, and its poisoning of drinking water is considered a se... more Arsenic is a pollutant in the environment, and its poisoning of drinking water is considered a severe global health issue. Chronic arsenic exposure is linked to an increased risk of a variety of diseases, including cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. Furthermore, arsenic exposure has been linked to changes in liver function and the development of hepatotoxicity. Furthermore, only a few studies have shown that persistent exposure to arsenic causes carcinogenesis, particularly cancers of the skin, bladder, and lungs. The current study looks at a variety of processes that play a role in arsenic-induced toxicity and end-organ damage.
Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in... more Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis, the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. The lesions of atherosclerosis occur principally in large and medium-sized elastic and muscular arteries and can lead to ischemia of the heart, brain, or extremities, resulting in infarction. They may be present throughout a person's lifetime. Among patients with established cardiovascular disease, mortality is lower among those who participate in an exercise program than among those who do not. Furthermore, recent studies have reported positive lipid-lowering effects from estrogen and/or progestogen in postmenopausal women but there are still conflicting reports on the use of these agents in dyslipi...
Elemental or metallic silver (Ag) is a very malleable and ductile transition metal that is white ... more Elemental or metallic silver (Ag) is a very malleable and ductile transition metal that is white metallic luster appearance. Nanoparticles are fine particles that have size nano-meter in range, that have dimension less than 100 nm (1nm-100nm). As their nano sized they have special physiochemical properties. Silver nano-particles (AgNPs) are one of most widely used nano-material that are used in personal care products, dressings as treatments for external wounds, ointments, and surgical instruments because of their effective antibacterial activity. AgNPs have broad spectrum antibacterial action that acts on both gram-negative and grampositive bacteria both, including antibiotic-resistant strains. AgNPs (diameter 5-20 nm, average diameter ~10 nm) also exhibit the antiviral property against HIV-1, hepatitis B virus, respiratory syncytial virus, herpes simplex virus type 1, and monkey pox virus. AgNPs as well as nano silver-derived solution and their product have showed the potent anti-inflammatory properties. As the consumption of nano-silver products are increasing, the chances of adverse effect on human health and environment are increasing. Generally AgNPs are less toxic than silver ion, but here are several in vitro in vivo studies shown that on exposure of AgNPs leads to cytotoxicity, immunotoxicity and genotoxicity to vertebrates. AgNPs causes blood diseases and colon cancer when it has been found in the blood and colon of patients respectively. kim et al 2008. Reported than 28 oral exposures of AgNPs at 30 mg/kg, 300 mg/kg and 1000 mg/kg in sprague dawley rats show dose dependent distribution of AgNPs in various organs and gender specific two fold more accumulation in female kidneys in comparison to male kidney. Usually the in vivo studies, in vitro studies with AgNPs showed that shown genotoxic effects, induction of DNA strand breaks, micronuclei, and chromosomal aberrationsat low non-cytotoxic doses in different types of human and mammalian cells.