Extracellular role of S100A4 calcium-binding protein in the periodontal ligament - PubMed (original) (raw)
. 1999 Feb 16;255(2):416-20.
doi: 10.1006/bbrc.1999.0214.
Affiliations
- PMID: 10049723
- DOI: 10.1006/bbrc.1999.0214
Extracellular role of S100A4 calcium-binding protein in the periodontal ligament
W R Duarte et al. Biochem Biophys Res Commun. 1999.
Abstract
S100A4 is a member of the S100 calcium-binding protein family. S100A4 is expressed in several tissues; however, it is secreted by few cell types and its extracellular roles are unknown. In the present study we showed by in situ hybridization that periodontal ligament (PDL) cells express the S100A4 mRNA. Immunolocalization of the S100A4 protein in cryosections of PDL and analyses of PDL cell culture medium revealed that PDL cells secrete the S100A4 protein both in vivo and in vitro. Interestingly, addition of a recombinant mouse S100A4 protein to a bone marrow cell culture inhibited mineralized nodule formation in a concentration-dependent manner. This is the first report of an extracellular role for S100A4 as an inhibitor of mineralization. The PDL space is kept free of mineralization and S100A4 may be one of the factors responsible for such phenomenon.
Copyright 1999 Academic Press.
Similar articles
- Effects of mechanical stress on the mRNA expression of S100A4 and cytoskeletal components by periodontal ligament cells.
Duarte WR, Mikuni-Takagaki Y, Kawase T, Limura T, Oida S, Ohya K, Takenaga K, Ishikawa L, Kasugai S. Duarte WR, et al. J Med Dent Sci. 1999 Sep;46(3):117-22. J Med Dent Sci. 1999. PMID: 12160257 - cDNA cloning of S100 calcium-binding proteins from bovine periodontal ligament and their expression in oral tissues.
Duarte WR, Kasugai S, Iimura T, Oida S, Takenaga K, Ohya K, Ishikawa I. Duarte WR, et al. J Dent Res. 1998 Sep;77(9):1694-9. doi: 10.1177/00220345980770090501. J Dent Res. 1998. PMID: 9759666 - S100A4 inhibition by RNAi up-regulates osteoblast related genes in periodontal ligament cells.
Kato C, Kojima T, Komaki M, Mimori K, Duarte WR, Takenaga K, Ishikawa I. Kato C, et al. Biochem Biophys Res Commun. 2005 Jan 7;326(1):147-53. doi: 10.1016/j.bbrc.2004.11.010. Biochem Biophys Res Commun. 2005. PMID: 15567164 - S100A4 and metastasis: a small actor playing many roles.
Boye K, Maelandsmo GM. Boye K, et al. Am J Pathol. 2010 Feb;176(2):528-35. doi: 10.2353/ajpath.2010.090526. Epub 2009 Dec 17. Am J Pathol. 2010. PMID: 20019188 Free PMC article. Review. - Calcium-binding protein S100A4 in health and disease.
Barraclough R. Barraclough R. Biochim Biophys Acta. 1998 Dec 10;1448(2):190-9. doi: 10.1016/s0167-4889(98)00143-8. Biochim Biophys Acta. 1998. PMID: 9920410 Review.
Cited by
- In vitro investigation of canine periodontal ligament-derived mesenchymal stem cells: A possibility of promising tool for periodontal regeneration.
Salari Sedigh H, Saffarpour A, Jamshidi S, Ashouri M, Nassiri SM, Dehghan MM, Ranjbar E, Shafieian R. Salari Sedigh H, et al. J Oral Biol Craniofac Res. 2023 May-Jun;13(3):403-411. doi: 10.1016/j.jobcr.2023.03.010. Epub 2023 Apr 18. J Oral Biol Craniofac Res. 2023. PMID: 37113531 Free PMC article. - Therapeutic and Metagenomic Potential of the Biomolecular Therapies against Periodontitis and the Oral Microbiome: Current Evidence and Future Perspectives.
Santonocito S, Ferlito S, Polizzi A, Ronsivalle V, Sclafani R, Valletta A, Lo Giudice A, Cavalcanti R, Spagnuolo G, Isola G. Santonocito S, et al. Int J Mol Sci. 2022 Nov 8;23(22):13708. doi: 10.3390/ijms232213708. Int J Mol Sci. 2022. PMID: 36430182 Free PMC article. Review. - Dual peptide-functionalized hydrogels differentially control periodontal cell function and promote tissue regeneration.
Fraser D, Benoit D. Fraser D, et al. Biomater Adv. 2022 Oct;141:213093. doi: 10.1016/j.bioadv.2022.213093. Epub 2022 Aug 31. Biomater Adv. 2022. PMID: 36067642 Free PMC article. - Non-coding RNA delivery for bone tissue engineering: Progress, challenges, and potential solutions.
Guan S, Zhang Z, Wu J. Guan S, et al. iScience. 2022 Jul 20;25(8):104807. doi: 10.1016/j.isci.2022.104807. eCollection 2022 Aug 19. iScience. 2022. PMID: 35992068 Free PMC article. Review. - Migration and Differentiation of GFP-transplanted Bone Marrow-derived Cells into Experimentally Induced Periodontal Polyp in Mice.
Matsuda S, Shoumura M, Osuga N, Tsujigiwa H, Nakano K, Okafuji N, Ochiai T, Hasegawa H, Kawakami T. Matsuda S, et al. Int J Med Sci. 2016 Jun 29;13(7):500-6. doi: 10.7150/ijms.15671. eCollection 2016. Int J Med Sci. 2016. PMID: 27429586 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials