p53-mutant clones and field effects in Barrett's esophagus - PubMed (original) (raw)

. 1999 Oct 1;59(19):4784-7.

Affiliations

PMID: 10519384

p53-mutant clones and field effects in Barrett's esophagus

L J Prevo et al. Cancer Res. 1999.

Abstract

Previous studies have demonstrated multifocal neoplasia in Barrett's esophagus. We evaluated 213 mapped, flow-purified, endoscopic biopsies to determine the distribution of p53-mutant clones in the Barrett's segments of 58 patients who had high-grade dysplasia without cancer. Twenty-nine patients (50%) had p53 mutations in their Barrett's segments, including 3 patients with multiple distinct p53 mutations. p53-mutant clones, including diploid cell populations, underwent expansion from 1 to 9 cm in the Barrett's segment. In 12 of 29 patients (41%) with a p53 mutation, the same mutation was found at every evaluated level of the metaplastic epithelium. This extensive p53-mutant clonal expansion suggests a somatic genetic basis for previous observations of field effects in Barrett's esophagus.

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p53-mutant clones and field effects in Barrett's esophagus - PubMed (original) (raw)