Four new members expand the interleukin-1 superfamily - PubMed (original) (raw)

. 2000 Jan 14;275(2):1169-75.

doi: 10.1074/jbc.275.2.1169.

Affiliations

• PMID: 10625660
• DOI: 10.1074/jbc.275.2.1169

Free article

Four new members expand the interleukin-1 superfamily

D E Smith et al. J Biol Chem. 2000.

Free article

Abstract

We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.

PubMed Disclaimer

Similar articles

• Genomic organization of the interleukin-1 locus.
  Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE. Taylor SL, et al. Genomics. 2002 May;79(5):726-33. doi: 10.1006/geno.2002.6752. Genomics. 2002. PMID: 11991723
• Identification and initial characterization of four novel members of the interleukin-1 family.
  Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR. Kumar S, et al. J Biol Chem. 2000 Apr 7;275(14):10308-14. doi: 10.1074/jbc.275.14.10308. J Biol Chem. 2000. PMID: 10744718
• Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.
  Eisenberg SP, Brewer MT, Verderber E, Heimdal P, Brandhuber BJ, Thompson RC. Eisenberg SP, et al. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5232-6. doi: 10.1073/pnas.88.12.5232. Proc Natl Acad Sci U S A. 1991. PMID: 1828896 Free PMC article.
• The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish.
  Huising MO, Stet RJ, Savelkoul HF, Verburg-van Kemenade BM. Huising MO, et al. Dev Comp Immunol. 2004 May 3;28(5):395-413. doi: 10.1016/j.dci.2003.09.005. Dev Comp Immunol. 2004. PMID: 15062640 Review.
• Virus-encoded homologs of cellular interleukin-10 and their control of host immune function.
  Slobedman B, Barry PA, Spencer JV, Avdic S, Abendroth A. Slobedman B, et al. J Virol. 2009 Oct;83(19):9618-29. doi: 10.1128/JVI.01098-09. Epub 2009 Jul 29. J Virol. 2009. PMID: 19640997 Free PMC article. Review. No abstract available.

Cited by

• The role of IL-36 and 37 in hepatocellular carcinoma.
  Cao J, Liu JH, Wise SG, Fan J, Bao S, Zheng GS. Cao J, et al. Front Immunol. 2024 Jan 19;15:1281121. doi: 10.3389/fimmu.2024.1281121. eCollection 2024. Front Immunol. 2024. PMID: 38312834 Free PMC article. Review.
• Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process.
  Gu M, Jin Y, Gao X, Xia W, Xu T, Pan S. Gu M, et al. Front Immunol. 2023 Oct 20;14:1278521. doi: 10.3389/fimmu.2023.1278521. eCollection 2023. Front Immunol. 2023. PMID: 37928545 Free PMC article. Review.
• The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARγ.
  Wei R, Han X, Li M, Ji Y, Zhang L, Christodoulou MI, Hameed Aga NJ, Zhang C, Gao R, Liu J, Fu J, Lu G, Xiao X, Liu X, Yang PC, McInnes IB, Sun Y, Gao P, Qin C, Huang SK, Zhou Y, Xu D. Wei R, et al. Cell Mol Immunol. 2023 Dec;20(12):1428-1444. doi: 10.1038/s41423-023-01091-0. Epub 2023 Oct 27. Cell Mol Immunol. 2023. PMID: 37891333
• The Pro-Tumor Biological Function of IL-36α Plays an Important Role in the Tumor Microenvironment of HCC.
  Song Y, Chu H, Liu F, Guo W, Gao N, Chen C, Bao S. Song Y, et al. Cancer Manag Res. 2023 Aug 29;15:895-904. doi: 10.2147/CMAR.S407123. eCollection 2023. Cancer Manag Res. 2023. PMID: 37663894 Free PMC article.
• Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet's Syndrome and Psoriatic Arthritis.
  Bettiol A, Fagni F, Mattioli I, Bagni G, Vitiello G, Grassi A, Della Bella C, Benagiano M, Troilo A, Holownia KS, Simon D, Argento FR, Sota J, Fabiani C, Becatti M, Fiorillo C, Schett G, Lopalco G, Cantarini L, Prisco D, Silvestri E, Emmi G, D'Elios MM. Bettiol A, et al. Int J Mol Sci. 2023 May 16;24(10):8817. doi: 10.3390/ijms24108817. Int J Mol Sci. 2023. PMID: 37240162 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)

• Miscellaneous

  • NCI CPTAC Assay Portal