Four new members expand the interleukin-1 superfamily - PubMed (original) (raw)

. 2000 Jan 14;275(2):1169-75.

doi: 10.1074/jbc.275.2.1169.

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• PMID: 10625660
• DOI: 10.1074/jbc.275.2.1169

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Four new members expand the interleukin-1 superfamily

D E Smith et al. J Biol Chem. 2000.

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Abstract

We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.

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