Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase - PubMed (original) (raw)

. 2000 Feb 1;345 Pt 3(Pt 3):719-24.

Affiliations

Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase

K Venkateswarlu et al. Biochem J. 2000.

Abstract

ADP-ribosylation factor (ARF) 6 regulates plasma membrane trafficking and cortical actin formation by cycling between inactive GDP and active GTP-bound conformations. Here we show that agonist stimulation of phosphatidylinositide 3-kinase (PI 3-kinase) activates a pathway that leads to ARF6 activation. We also describe experiments that propose a central role in this pathway for the PI 3-kinase-dependent plasma membrane recruitment of the cytohesin-1 family of PtdIns(3,4,5)P(3)-binding ARF-exchange factors.

PubMed Disclaimer

References

    1. Cell. 1996 Jul 26;86(2):233-42 - PubMed
    1. J Biol Chem. 1999 Sep 17;274(38):27099-104 - PubMed
    1. J Biol Chem. 1996 Sep 6;271(36):21767-74 - PubMed
    1. Nature. 1996 Dec 5;384(6608):481-4 - PubMed
    1. Science. 1997 Mar 28;275(5308):1927-30 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources