Asymmetric Synthesis of the Nakijiquinones-Selective Inhibitors of the Her-2/Neu Protooncogene - PubMed (original) (raw)
. 1999 Dec 16;38(24):3710-3713.
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- PMID: 10649333
Asymmetric Synthesis of the Nakijiquinones-Selective Inhibitors of the Her-2/Neu Protooncogene
P Stahl et al. Angew Chem Int Ed Engl. 1999.
Abstract
A Wieland-Miescher type ketone and a tetramethoxyaryl derivative are the key building blocks for the enantioselective total synthesis of nakijiquinone C (1). The nakijiquinones are the only natural products known that selectively inhibit the Her-2/Neu tyrosine kinase, a protooncogene product that is vastly overexpressed in about 30 % of primary breast, ovary, and gastric carcinomas.
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