The importance of shedding of membrane proteins for cytokine biology - PubMed (original) (raw)
Affiliations
- PMID: 10705296
Free article
Review
The importance of shedding of membrane proteins for cytokine biology
J Müllberg et al. Eur Cytokine Netw. 2000 Mar.
Free article
Abstract
Most transmembrane proteins are subjected to limited proteolysis by cellular proteases. The recent molecular cloning of the TNF-a converting enzyme (TACE) revealed that this shedding enzyme belongs to a family of metalloproteinases which contain a disintegrin domain (ADAM family). The activity of these proteases seems to be tightly regulated. Mice lacking functional TACE are not viable demonstrating the importance of this enzyme for body homeostasis. This review describes the current knowledge of shedding enzymes, the ADAM protein family, the mechanism of shedding as well as physiological consequences of shedding of cytokines and cytokine receptors for cytokine biology.
Similar articles
- Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases.
Hiraoka Y, Yoshida K, Ohno M, Matsuoka T, Kita T, Nishi E. Hiraoka Y, et al. Biochem Biophys Res Commun. 2008 May 23;370(1):154-8. doi: 10.1016/j.bbrc.2008.03.050. Epub 2008 Mar 18. Biochem Biophys Res Commun. 2008. PMID: 18355445 - Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE).
Killar L, White J, Black R, Peschon J. Killar L, et al. Ann N Y Acad Sci. 1999 Jun 30;878:442-52. doi: 10.1111/j.1749-6632.1999.tb07701.x. Ann N Y Acad Sci. 1999. PMID: 10415747 Review. - Shedding of membrane proteins by ADAM family proteases.
Moss ML, Lambert MH. Moss ML, et al. Essays Biochem. 2002;38:141-53. doi: 10.1042/bse0380141. Essays Biochem. 2002. PMID: 12463167 Review.
Cited by
- A Bitter Experience That Enlightens the Future: COVID-19 Neurological Affection and Perspectives on the Orexigenic System.
Abdelmissih S. Abdelmissih S. Cureus. 2022 Oct 28;14(10):e30788. doi: 10.7759/cureus.30788. eCollection 2022 Oct. Cureus. 2022. PMID: 36457603 Free PMC article. Review. - Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.
Diener N, Fontaine JF, Klein M, Hieronymus T, Wanke F, Kurschus FC, Ludwig A, Ware C, Saftig P, Bopp T, Clausen BE, Backer RA. Diener N, et al. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2111234118. doi: 10.1073/pnas.2111234118. Proc Natl Acad Sci U S A. 2021. PMID: 34526403 Free PMC article. - Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases.
Lopes PH, van den Berg CW, Tambourgi DV. Lopes PH, et al. Front Pharmacol. 2020 May 13;11:636. doi: 10.3389/fphar.2020.00636. eCollection 2020. Front Pharmacol. 2020. PMID: 32477123 Free PMC article. - MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer.
Xu X, Padilla MT, Li B, Wells A, Kato K, Tellez C, Belinsky SA, Kim KC, Lin Y. Xu X, et al. Cancer Res. 2014 Jan 15;74(2):460-70. doi: 10.1158/0008-5472.CAN-13-1713. Epub 2013 Nov 26. Cancer Res. 2014. PMID: 24282280 Free PMC article. - Dominant-negative effect of truncated mannose 6-phosphate/insulin-like growth factor II receptor species in cancer.
Kreiling JL, Montgomery MA, Wheeler JR, Kopanic JL, Connelly CM, Zavorka ME, Allison JL, Macdonald RG. Kreiling JL, et al. FEBS J. 2012 Aug;279(15):2695-713. doi: 10.1111/j.1742-4658.2012.08652.x. Epub 2012 Jul 2. FEBS J. 2012. PMID: 22681933 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous