TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice - PubMed (original) (raw)
TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice
D Zhang et al. Nat Med. 2000 May.
Abstract
The transforming-growth-factor-beta-activated kinase TAK1 is a member of the mitogen-activated protein kinase kinase kinase family, which couples extracellular stimuli to gene transcription. The in vivo function of TAK1 is not understood. Here, we investigated the potential involvement of TAK1 in cardiac hypertrophy. In adult mouse myocardium, TAK1 kinase activity was upregulated 7 days after aortic banding, a mechanical load that induces hypertrophy and expression of transforming growth factor beta. An activating mutation of TAK1 expressed in myocardium of transgenic mice was sufficient to produce p38 mitogen-activated protein kinase phosphorylation in vivo, cardiac hypertrophy, interstitial fibrosis, severe myocardial dysfunction, 'fetal' gene induction, apoptosis and early lethality. Thus, TAK1 activity is induced as a delayed response to mechanical stress, and can suffice to elicit myocardial hypertrophy and fulminant heart failure.
Similar articles
- Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch.
Takeishi Y, Huang Q, Abe J, Glassman M, Che W, Lee JD, Kawakatsu H, Lawrence EG, Hoit BD, Berk BC, Walsh RA. Takeishi Y, et al. J Mol Cell Cardiol. 2001 Sep;33(9):1637-48. doi: 10.1006/jmcc.2001.1427. J Mol Cell Cardiol. 2001. PMID: 11549343 - Mitogen-activated protein kinases (p38 and c-Jun NH2-terminal kinase) are differentially regulated during cardiac volume and pressure overload hypertrophy.
Sopontammarak S, Aliharoob A, Ocampo C, Arcilla RA, Gupta MP, Gupta M. Sopontammarak S, et al. Cell Biochem Biophys. 2005;43(1):61-76. doi: 10.1385/CBB:43:1:061. Cell Biochem Biophys. 2005. PMID: 16043884 - TGF-β1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney.
Ma FY, Tesch GH, Ozols E, Xie M, Schneider MD, Nikolic-Paterson DJ. Ma FY, et al. Am J Physiol Renal Physiol. 2011 Jun;300(6):F1410-21. doi: 10.1152/ajprenal.00018.2011. Epub 2011 Mar 2. Am J Physiol Renal Physiol. 2011. PMID: 21367917 - [Transforming growth factor-β-activated kinase 1 and pathological myocardial hypertrophy].
Li Y, Chen Y, Zhang DM. Li Y, et al. Sheng Li Xue Bao. 2020 Aug 25;72(4):499-505. Sheng Li Xue Bao. 2020. PMID: 32820312 Review. Chinese. - Emerging role of TAK1 in the regulation of skeletal muscle mass.
Roy A, Narkar VA, Kumar A. Roy A, et al. Bioessays. 2023 Apr;45(4):e2300003. doi: 10.1002/bies.202300003. Epub 2023 Feb 15. Bioessays. 2023. PMID: 36789559 Free PMC article. Review.
Cited by
- Cardiac Hypertrophy: From Pathophysiological Mechanisms to Heart Failure Development.
Caturano A, Vetrano E, Galiero R, Salvatore T, Docimo G, Epifani R, Alfano M, Sardu C, Marfella R, Rinaldi L, Sasso FC. Caturano A, et al. Rev Cardiovasc Med. 2022 May 6;23(5):165. doi: 10.31083/j.rcm2305165. eCollection 2022 May. Rev Cardiovasc Med. 2022. PMID: 39077592 Free PMC article. Review. - Downregulation of Mitochondrial Fusion Protein Expression Affords Protection from Canonical Necroptosis in H9c2 Cardiomyoblasts.
Toda Y, Ong SB, Yano T, Kuno A, Kouzu H, Sato T, Ohwada W, Tatekoshi Y, Ogawa T, Shimizu M, Tanno M, Furuhashi M. Toda Y, et al. Int J Mol Sci. 2024 Mar 2;25(5):2905. doi: 10.3390/ijms25052905. Int J Mol Sci. 2024. PMID: 38474152 Free PMC article. - TAK1 Activation by NLRP3 Deficiency Confers Cardioprotection Against Pressure Overload-Induced Cardiomyocyte Pyroptosis and Hypertrophy.
Li X, You J, Dai F, Wang S, Yang FH, Wang X, Ding Z, Huang J, Chen L, Abudureyimu M, Tang H, Yang X, Xiang Y, Backx PH, Ren J, Ge J, Zou Y, Wu J. Li X, et al. JACC Basic Transl Sci. 2023 Aug 9;8(12):1555-1573. doi: 10.1016/j.jacbts.2023.05.008. eCollection 2023 Dec. JACC Basic Transl Sci. 2023. PMID: 38205342 Free PMC article. - Transforming growth factor-β and bone morphogenetic protein signaling pathways in pathological cardiac hypertrophy.
Wen J, Liu G, Liu M, Wang H, Wan Y, Yao Z, Gao N, Sun Y, Zhu L. Wen J, et al. Cell Cycle. 2023 Nov;22(21-22):2467-2484. doi: 10.1080/15384101.2023.2293595. Epub 2024 Jan 18. Cell Cycle. 2023. PMID: 38179789 Free PMC article. Review. - Guanxinning tablets improve myocardial hypertrophy by inhibiting the activation of MEK-ERK1/2 signaling pathway.
Zhang Y, Huang Y, Ma QX, Xu ST, Shen L, Xu YY, Hai-Ye T, Chen ML, Rong YL. Zhang Y, et al. J Appl Biomed. 2023 Sep;21(3):137-149. doi: 10.32725/jab.2023.014. Epub 2023 Sep 18. J Appl Biomed. 2023. PMID: 37747313
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous