Natural killer cells determine the outcome of B cell-mediated autoimmunity - PubMed (original) (raw)
Natural killer cells determine the outcome of B cell-mediated autoimmunity
F D Shi et al. Nat Immunol. 2000 Sep.
Abstract
Natural killer (NK) cells can affect the outcome of adaptive immune responses. NK cells, but not NK1.1+T cells, were found to participate in the development of myasthenia gravis (a T cell-dependent, B cell- and antibody-mediated autoimmune disease) in C57BL/6 mice. The requirement for NK cells was reflected by the lack of a type I helper T cell response and antibodies to the acetylcholine receptor in both NK1.1+ cell-depleted and NK cell-deficient IL-18-/- mice. These findings establish a previously unrecognized link between NK cells and autoreactive T and B cells.
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