The effect of testosterone replacement treatment on immunological features of patients with Klinefelter's syndrome - PubMed (original) (raw)

The effect of testosterone replacement treatment on immunological features of patients with Klinefelter's syndrome

I H Koçar et al. Clin Exp Immunol. 2000 Sep.

Abstract

Although the effects of androgen deficiency in the immune system have long been appreciated, little is known about the immunological features of patients with Klinefelter's syndrome (KS). On the other hand, interest in androgens as a possible treatment for some autoimmune diseases is growing. In the present study, some immunological parameters were evaluated in 26 patients with KS prior to androgen replacement treatment (ART) and the results were compared with those in 19 healthy control subjects. Patients were then treated with testosterone for 6 months and the pre- and post-treatment findings were compared. Serum levels of IgG, IgA, IgM, C3c and C4 were measured by nephelometry and lymphocyte subsets and CD4+/CD8+ ratios were examined by flow cytometry. IL-2 and IL-4 levels were measured by ELISA. Pretreatment levels of the serum IgA, IgG, IgM, IL-2 and IL-4 of the patients were higher than those of the controls and were all decreased significantly following ART. The pretreatment absolute numbers and percentages of CD3+, CD4+, CD19+ cells and CD4+/CD8+ ratios of patients with KS were higher than those of the controls and were all decreased with ART. Percentages of CD8+ cells were increased significantly, while C3 and C4 levels were both significantly decreased after ART. It is concluded that the lack of testosterone in patients with KS enhances cellular and humoral immunity and that ART may suppress this.

PubMed Disclaimer

Similar articles

• The effects of gonadotropin treatment on the immunological features of male patients with idiopathic hypogonadotropic hypogonadism.
  Yesilova Z, Ozata M, Kocar IH, Turan M, Pekel A, Sengul A, Ozdemír IC. Yesilova Z, et al. J Clin Endocrinol Metab. 2000 Jan;85(1):66-70. doi: 10.1210/jcem.85.1.6226. J Clin Endocrinol Metab. 2000. PMID: 10634365 Clinical Trial.
• Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's syndrome.
  Bizzarro A, Valentini G, Di Martino G, DaPonte A, De Bellis A, Iacono G. Bizzarro A, et al. J Clin Endocrinol Metab. 1987 Jan;64(1):32-6. doi: 10.1210/jcem-64-1-32. J Clin Endocrinol Metab. 1987. PMID: 3097058
• Bone mineral density and quantitative ultrasound parameters in patients with Klinefelter's syndrome after long-term testosterone substitution.
  van den Bergh JP, Hermus AR, Spruyt AI, Sweep CG, Corstens FH, Smals AG. van den Bergh JP, et al. Osteoporos Int. 2001;12(1):55-62. doi: 10.1007/s001980170158. Osteoporos Int. 2001. PMID: 11305084
• Effects of hormone replacement therapy on immunological factors in the postmenopausal period.
  Abdi F, Mobedi H, Mosaffa N, Dolatian M, Ramezani Tehrani F. Abdi F, et al. Climacteric. 2016 Jun;19(3):234-9. doi: 10.3109/13697137.2016.1164136. Epub 2016 Apr 18. Climacteric. 2016. PMID: 27086591 Review.
• Osteoporosis in Klinefelter's syndrome.
  Ferlin A, Schipilliti M, Di Mambro A, Vinanzi C, Foresta C. Ferlin A, et al. Mol Hum Reprod. 2010 Jun;16(6):402-10. doi: 10.1093/molehr/gaq026. Epub 2010 Mar 27. Mol Hum Reprod. 2010. PMID: 20348548 Review.

Cited by

• Biological Sex and Pregnancy Affect Influenza Pathogenesis and Vaccination.
  Creisher PS, Seddu K, Mueller AL, Klein SL. Creisher PS, et al. Curr Top Microbiol Immunol. 2023;441:111-137. doi: 10.1007/978-3-031-35139-6_5. Curr Top Microbiol Immunol. 2023. PMID: 37695427
• Sex and Gender Differences in Bacterial Infections.
  Dias SP, Brouwer MC, van de Beek D. Dias SP, et al. Infect Immun. 2022 Oct 20;90(10):e0028322. doi: 10.1128/iai.00283-22. Epub 2022 Sep 19. Infect Immun. 2022. PMID: 36121220 Free PMC article. Review.
• Cancer-specific survival after diagnosis in men versus women: A pan-cancer analysis.
  He Y, Su Y, Zeng J, Chong W, Hu X, Zhang Y, Peng X. He Y, et al. MedComm (2020). 2022 Jun 30;3(3):e145. doi: 10.1002/mco2.145. eCollection 2022 Sep. MedComm (2020). 2022. PMID: 35783087 Free PMC article.
• The spectrum of sex differences in cancer.
  Rubin JB. Rubin JB. Trends Cancer. 2022 Apr;8(4):303-315. doi: 10.1016/j.trecan.2022.01.013. Epub 2022 Feb 18. Trends Cancer. 2022. PMID: 35190302 Free PMC article. Review.
• Sex Differences in Immunity.
  Wilkinson NM, Chen HC, Lechner MG, Su MA. Wilkinson NM, et al. Annu Rev Immunol. 2022 Apr 26;40:75-94. doi: 10.1146/annurev-immunol-101320-125133. Epub 2022 Jan 5. Annu Rev Immunol. 2022. PMID: 34985929 Free PMC article. Review.

References

1. 1. Ahmed SA, Penhale WJ, Talal N. Sex hormones, immune responses and autoimmune diseases. Am J Pathol. 1985;121:531–51. - PMC - PubMed
2. 1. Beeson PB. Age and sex associations of 40 autoimmune diseases. Am J Med. 1994;96:457–62. - PubMed
3. 1. Cutolo M, Sulli A, Seriolo B, et al. Estrogens, the immune response and autoimmunity. Clin Exp Rheumatol. 1995;13:217–26. - PubMed
4. 1. Sullivan DA. Sex hormones and Sjögren's syndrome. J Rheumatol. 1997;24(Suppl. 50):17–32. - PubMed
5. 1. Butterworth M, McClellan B, Allansmith M. Influence of sex in immunoglobulin levels. Nature. 1967;214:1224–5. - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • PubMed Central
  • Silverchair Information Systems
  • Wiley

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal