Microtubule motors in mitosis - PubMed (original) (raw)

Review

. 2000 Sep 7;407(6800):41-7.

doi: 10.1038/35024000.

Affiliations

• PMID: 10993066
• DOI: 10.1038/35024000

Review

Microtubule motors in mitosis

D J Sharp et al. Nature. 2000.

Abstract

The mitotic spindle uses microtubule-based motor proteins to assemble itself and to segregate sister chromatids. It is becoming clear that motors invoke several distinct mechanisms to generate the forces that drive mitosis. Moreover, in carrying out its function, the spindle appears to pass through a series of transient steady-state structures, each established by a delicate balance of forces generated by multiple complementary and antagonistic motors. Transitions from one steady state to the next can occur when a change in the activity of a subset of mitotic motors tips the balance.

PubMed Disclaimer

Similar articles

• Cell biology. Serving up a plate of chromosomes.
  Heald R. Heald R. Science. 2006 Jan 20;311(5759):343-4. doi: 10.1126/science.1123525. Science. 2006. PMID: 16424328 No abstract available.
• Mitotic microtubule crosslinkers: insights from mechanistic studies.
  Peterman EJ, Scholey JM. Peterman EJ, et al. Curr Biol. 2009 Dec 15;19(23):R1089-94. doi: 10.1016/j.cub.2009.10.047. Curr Biol. 2009. PMID: 20064413 Review.
• Spindle microtubules: getting attached at both ends.
  DeLuca JG. DeLuca JG. Curr Biol. 2007 Nov 20;17(22):R966-9. doi: 10.1016/j.cub.2007.09.040. Curr Biol. 2007. PMID: 18029252 Review.
• The mitotic spindle: a self-made machine.
  Karsenti E, Vernos I. Karsenti E, et al. Science. 2001 Oct 19;294(5542):543-7. doi: 10.1126/science.1063488. Science. 2001. PMID: 11641489 Review.
• The spindle: a dynamic assembly of microtubules and motors.
  Wittmann T, Hyman A, Desai A. Wittmann T, et al. Nat Cell Biol. 2001 Jan;3(1):E28-34. doi: 10.1038/35050669. Nat Cell Biol. 2001. PMID: 11146647 Review.

Cited by

• Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone.
  Thomas EC, Ismael A, Moore JK. Thomas EC, et al. Mol Biol Cell. 2020 Nov 15;31(24):2733-2747. doi: 10.1091/mbc.E20-07-0493-T. Epub 2020 Sep 30. Mol Biol Cell. 2020. PMID: 32997572 Free PMC article.
• Development of a Drosophila cell-based error correction assay.
  Salemi JD, McGilvray PT, Maresca TJ. Salemi JD, et al. Front Oncol. 2013 Jul 23;3:187. doi: 10.3389/fonc.2013.00187. eCollection 2013. Front Oncol. 2013. PMID: 23888285 Free PMC article.
• Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
  Kasahara M, Nagahara M, Nakagawa T, Ishikawa T, Sato T, Uetake H, Sugihara K. Kasahara M, et al. Oncol Lett. 2016 Sep;12(3):1909-1914. doi: 10.3892/ol.2016.4823. Epub 2016 Jul 7. Oncol Lett. 2016. PMID: 27588139 Free PMC article.
• Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology.
  Rojas AM, Santamaria A, Malik R, Jensen TS, Körner R, Morilla I, de Juan D, Krallinger M, Hansen DA, Hoffmann R, Lees J, Reid A, Yeats C, Wehner A, Elowe S, Clegg AB, Brunak S, Nigg EA, Orengo C, Valencia A, Ranea JA. Rojas AM, et al. PLoS One. 2012;7(3):e31813. doi: 10.1371/journal.pone.0031813. Epub 2012 Mar 9. PLoS One. 2012. PMID: 22427808 Free PMC article.
• Opposite-polarity motors activate one another to trigger cargo transport in live cells.
  Ally S, Larson AG, Barlan K, Rice SE, Gelfand VI. Ally S, et al. J Cell Biol. 2009 Dec 28;187(7):1071-82. doi: 10.1083/jcb.200908075. J Cell Biol. 2009. PMID: 20038680 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • FlyBase