A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs - PubMed (original) (raw)
Comparative Study
. 2000 Dec 29;279(3):832-7.
doi: 10.1006/bbrc.2000.4042.
Affiliations
- PMID: 11162436
- DOI: 10.1006/bbrc.2000.4042
Comparative Study
A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs
F Marqués et al. Biochem Biophys Res Commun. 2000.
Abstract
Kinases of the CDC2 family play a key role in cell cycle regulation and gene expression. In the present work, we identified sea urchin and human cDNAs encoding homologues of a high molecular mass CDC2-like kinase (designated CDC2L5) sharing respectively a PITAVRE and PITAIRE motif. The human cDNA encodes the full-length amino acid sequence of the cholinesterase-related cell division controller (CHED) kinase, a previously published partial coding sequence. CDC2L5 overexpressed in mammalian cells is an approximately 170-kDa nuclear protein. The mRNA is present during the sea urchin early embryogenesis and is ubiquitously expressed in human tissues.
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