Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory - PubMed (original) (raw)

. 2001 May 17;411(6835):309-13.

doi: 10.1038/35077089.

Affiliations

• PMID: 11357133
• DOI: 10.1038/35077089

Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory

P W Frankland et al. Nature. 2001.

Abstract

Cortical plasticity seems to be critical for the establishment of permanent memory traces. Little is known, however, about the molecular and cellular processes that support consolidation of memories in cortical networks. Here we show that mice heterozygous for a null mutation of alpha-calcium-calmodulin kinase II (alpha-CaMKII+/-) show normal learning and memory 1-3 days after training in two hippocampus-dependent tasks. However, their memory is severely impaired at longer retention delays (10-50 days). Consistent with this, we found that alpha-CaMKII+/- mice have impaired cortical, but not hippocampal, long-term potentiation. Our results represent a first step in unveiling the molecular and cellular mechanisms underlying the establishment of permanent memories, and they indicate that alpha-CaMKII may modulate the synaptic events required for the consolidation of memory traces in cortical networks.

PubMed Disclaimer

Comment in

• Memory. Why is the cortex a slow learner?
  Lisman J, Morris RG. Lisman J, et al. Nature. 2001 May 17;411(6835):248-9. doi: 10.1038/35077185. Nature. 2001. PMID: 11357109 No abstract available.

Similar articles

• Memory. Why is the cortex a slow learner?
  Lisman J, Morris RG. Lisman J, et al. Nature. 2001 May 17;411(6835):248-9. doi: 10.1038/35077185. Nature. 2001. PMID: 11357109 No abstract available.
• The involvement of the anterior cingulate cortex in remote contextual fear memory.
  Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ. Frankland PW, et al. Science. 2004 May 7;304(5672):881-3. doi: 10.1126/science.1094804. Science. 2004. PMID: 15131309
• A fresh look at the role of CaMKII in hippocampal synaptic plasticity and memory.
  Rongo C. Rongo C. Bioessays. 2002 Mar;24(3):223-33. doi: 10.1002/bies.10057. Bioessays. 2002. PMID: 11891759 Review.
• Glial protein S100B modulates long-term neuronal synaptic plasticity.
  Nishiyama H, Knopfel T, Endo S, Itohara S. Nishiyama H, et al. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4037-42. doi: 10.1073/pnas.052020999. Epub 2002 Mar 12. Proc Natl Acad Sci U S A. 2002. PMID: 11891290 Free PMC article.
• The molecular basis of CaMKII function in synaptic and behavioural memory.
  Lisman J, Schulman H, Cline H. Lisman J, et al. Nat Rev Neurosci. 2002 Mar;3(3):175-90. doi: 10.1038/nrn753. Nat Rev Neurosci. 2002. PMID: 11994750 Review.

Cited by

• Effect of Ketamine on LTP and NMDAR EPSC in Hippocampus of the Chronic Social Defeat Stress Mice Model of Depression.
  Yang Y, Ju W, Zhang H, Sun L. Yang Y, et al. Front Behav Neurosci. 2018 Oct 9;12:229. doi: 10.3389/fnbeh.2018.00229. eCollection 2018. Front Behav Neurosci. 2018. PMID: 30356718 Free PMC article.
• Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation.
  Almeida-Filho DG, Queiroz CM, Ribeiro S. Almeida-Filho DG, et al. Cell Mol Life Sci. 2018 Oct;75(20):3715-3740. doi: 10.1007/s00018-018-2886-9. Epub 2018 Jul 27. Cell Mol Life Sci. 2018. PMID: 30054638 Free PMC article. Review.
• Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons.
  Murano T, Nakajima R, Nakao A, Hirata N, Amemori S, Murakami A, Kamitani Y, Yamamoto J, Miyakawa T. Murano T, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2106830119. doi: 10.1073/pnas.2106830119. Epub 2022 Aug 5. Proc Natl Acad Sci U S A. 2022. PMID: 35930667 Free PMC article.
• Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.
  Tao J, Hu K, Chang Q, Wu H, Sherman NE, Martinowich K, Klose RJ, Schanen C, Jaenisch R, Wang W, Sun YE. Tao J, et al. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7. doi: 10.1073/pnas.0811648106. Epub 2009 Feb 18. Proc Natl Acad Sci U S A. 2009. PMID: 19225110 Free PMC article.
• A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.
  Matynia A, Anagnostaras SG, Wiltgen BJ, Lacuesta M, Fanselow MS, Silva AJ. Matynia A, et al. PLoS One. 2008 May 7;3(5):e2121. doi: 10.1371/journal.pone.0002121. PLoS One. 2008. PMID: 18464936 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group
  • Ovid Technologies, Inc.

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)