Regional mu opioid receptor regulation of sensory and affective dimensions of pain - PubMed (original) (raw)
Clinical Trial
. 2001 Jul 13;293(5528):311-5.
doi: 10.1126/science.1060952.
Affiliations
- PMID: 11452128
- DOI: 10.1126/science.1060952
Clinical Trial
Regional mu opioid receptor regulation of sensory and affective dimensions of pain
J K Zubieta et al. Science. 2001.
Abstract
The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. We examined the function of the opioid system and mu-opioid receptors in the brains of healthy human subjects undergoing sustained pain. Sustained pain induced the regional release of endogenous opioids interacting with mu-opioid receptors in a number of cortical and subcortical brain regions. The activation of the mu-opioid receptor system was associated with reductions in the sensory and affective ratings of the pain experience, with distinct neuroanatomical involvements. These data demonstrate the central role of the mu-opioid receptors and their endogenous ligands in the regulation of sensory and affective components of the pain experience.
Similar articles
- Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission.
Zubieta JK, Ketter TA, Bueller JA, Xu Y, Kilbourn MR, Young EA, Koeppe RA. Zubieta JK, et al. Arch Gen Psychiatry. 2003 Nov;60(11):1145-53. doi: 10.1001/archpsyc.60.11.1145. Arch Gen Psychiatry. 2003. PMID: 14609890 - Differential opioid action on sensory and affective cerebral pain processing.
Oertel BG, Preibisch C, Wallenhorst T, Hummel T, Geisslinger G, Lanfermann H, Lötsch J. Oertel BG, et al. Clin Pharmacol Ther. 2008 Apr;83(4):577-88. doi: 10.1038/sj.clpt.6100441. Epub 2007 Nov 21. Clin Pharmacol Ther. 2008. PMID: 18030306 - Acute opioid effects on human brain as revealed by functional magnetic resonance imaging.
Leppä M, Korvenoja A, Carlson S, Timonen P, Martinkauppi S, Ahonen J, Rosenberg PH, Aronen HJ, Kalso E. Leppä M, et al. Neuroimage. 2006 Jun;31(2):661-9. doi: 10.1016/j.neuroimage.2005.12.019. Epub 2006 Feb 3. Neuroimage. 2006. PMID: 16459107 - Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone).
Pergolizzi J, Böger RH, Budd K, Dahan A, Erdine S, Hans G, Kress HG, Langford R, Likar R, Raffa RB, Sacerdote P. Pergolizzi J, et al. Pain Pract. 2008 Jul-Aug;8(4):287-313. doi: 10.1111/j.1533-2500.2008.00204.x. Epub 2008 May 23. Pain Pract. 2008. PMID: 18503626
Cited by
- Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception.
Dou YN, Liu Y, Ding WQ, Li Q, Zhou H, Li L, Zhao MT, Li ZY, Yuan J, Wang XF, Zou WY, Li A, Sun YG. Dou YN, et al. Natl Sci Rev. 2024 Jun 4;11(7):nwae195. doi: 10.1093/nsr/nwae195. eCollection 2024 Jul. Natl Sci Rev. 2024. PMID: 39045468 Free PMC article. - Polymorphisms of the μ-opioid receptor gene influence cerebral pain processing in fibromyalgia.
Ellerbrock I, Sandström A, Tour J, Kadetoff D, Schalling M, Jensen KB, Kosek E. Ellerbrock I, et al. Eur J Pain. 2021 Feb;25(2):398-414. doi: 10.1002/ejp.1680. Epub 2020 Nov 2. Eur J Pain. 2021. PMID: 33064887 Free PMC article. - Chronic Back Pain Is Associated with Alterations in Dopamine Neurotransmission in the Ventral Striatum.
Martikainen IK, Nuechterlein EB, Peciña M, Love TM, Cummiford CM, Green CR, Stohler CS, Zubieta JK. Martikainen IK, et al. J Neurosci. 2015 Jul 8;35(27):9957-65. doi: 10.1523/JNEUROSCI.4605-14.2015. J Neurosci. 2015. PMID: 26156996 Free PMC article. - Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects.
Wanigasekera V, Lee MC, Rogers R, Kong Y, Leknes S, Andersson J, Tracey I. Wanigasekera V, et al. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17705-10. doi: 10.1073/pnas.1120201109. Epub 2012 Oct 8. Proc Natl Acad Sci U S A. 2012. PMID: 23045652 Free PMC article. - µ-Opioid Activity in Chronic TMD Pain Is Associated with COMT Polymorphism.
Nascimento TD, Yang N, Salman D, Jassar H, Kaciroti N, Bellile E, Danciu T, Koeppe R, Stohler C, Zubieta JK, Ellingrod V, DaSilva AF. Nascimento TD, et al. J Dent Res. 2019 Nov;98(12):1324-1331. doi: 10.1177/0022034519871938. Epub 2019 Sep 6. J Dent Res. 2019. PMID: 31490699 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials