PUMA induces the rapid apoptosis of colorectal cancer cells - PubMed (original) (raw)
PUMA induces the rapid apoptosis of colorectal cancer cells
J Yu et al. Mol Cell. 2001 Mar.
Free article
Abstract
Through global profiling of genes that were expressed soon after p53 expression, we identified a novel gene termed PUMA (p53 upregulated modulator of apoptosis). The protein encoded by PUMA was found to be exclusively mitochondrial and to bind to Bcl-2 and Bcl-X(L) through a BH3 domain. Exogenous expression of PUMA resulted in an extremely rapid and profound apoptosis that occurred much earlier than that resulting from exogenous expression of p53. Based on its unique expression patterns, p53 dependence, and biochemical properties, PUMA may be a direct mediator of p53-associated apoptosis.
Similar articles
- PUMA, a novel proapoptotic gene, is induced by p53.
Nakano K, Vousden KH. Nakano K, et al. Mol Cell. 2001 Mar;7(3):683-94. doi: 10.1016/s1097-2765(01)00214-3. Mol Cell. 2001. PMID: 11463392 - PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.
Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR. Chipuk JE, et al. Science. 2005 Sep 9;309(5741):1732-5. doi: 10.1126/science.1114297. Science. 2005. PMID: 16151013 - Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1.
Nakajima W, Tanaka N. Nakajima W, et al. Biochem Biophys Res Commun. 2011 Oct 7;413(4):643-8. doi: 10.1016/j.bbrc.2011.09.036. Epub 2011 Sep 14. Biochem Biophys Res Commun. 2011. PMID: 21945433 - Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. Oda E, et al. Science. 2000 May 12;288(5468):1053-8. doi: 10.1126/science.288.5468.1053. Science. 2000. PMID: 10807576 - Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1.
Mei Y, Du W, Yang Y, Wu M. Mei Y, et al. Oncogene. 2005 Nov 3;24(48):7224-37. doi: 10.1038/sj.onc.1208873. Oncogene. 2005. PMID: 16007132
Cited by
- Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets.
Sharma Y, Gupta JK, Babu MA, Singh S, Sindhu RK. Sharma Y, et al. J Mol Neurosci. 2024 Oct 28;74(4):101. doi: 10.1007/s12031-024-02269-5. J Mol Neurosci. 2024. PMID: 39466510 Review. - Differential effect of plakoglobin in restoring the tumor suppressor activities of p53-R273H vs. p53-R175H mutants.
Lo CS, Alavi P, Bassey-Archibong B, Jahroudi N, Pasdar M. Lo CS, et al. PLoS One. 2024 Oct 3;19(10):e0306705. doi: 10.1371/journal.pone.0306705. eCollection 2024. PLoS One. 2024. PMID: 39361615 Free PMC article. - Unraveling cancer progression pathways and phytochemical therapeutic strategies for its management.
Sharma V, Chaudhary AA, Bawari S, Gupta S, Mishra R, Khan SU, Ali MAM, Shahid M, Srivastava S, Verma D, Gupta A, Kumar S, Kumar S. Sharma V, et al. Front Pharmacol. 2024 Aug 23;15:1414790. doi: 10.3389/fphar.2024.1414790. eCollection 2024. Front Pharmacol. 2024. PMID: 39246660 Free PMC article. Review. - Mouse models to investigate in situ cell fate decisions induced by p53.
Lieschke E, Thomas AF, Kueh A, Atkin-Smith GK, Baldoni PL, La Marca JE, Young S, Huang AS, Ross AM, Whelan L, Kaloni D, Tai L, Smyth GK, Herold MJ, Hawkins ED, Strasser A, Kelly GL. Lieschke E, et al. EMBO J. 2024 Oct;43(19):4406-4436. doi: 10.1038/s44318-024-00189-z. Epub 2024 Aug 19. EMBO J. 2024. PMID: 39160273 Free PMC article. - Determinants of p53 DNA binding, gene regulation, and cell fate decisions.
Fischer M, Sammons MA. Fischer M, et al. Cell Death Differ. 2024 Jul;31(7):836-843. doi: 10.1038/s41418-024-01326-1. Epub 2024 Jun 29. Cell Death Differ. 2024. PMID: 38951700 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
Miscellaneous