Feeding-related immune responsive brain stem neurons: association with CGRP - PubMed (original) (raw)

Feeding-related immune responsive brain stem neurons: association with CGRP

J Paues et al. Neuroreport. 2001.

Erratum in

• Neuroreport 2001 Nov 16;12(16):inside back cover
• Neuroreport 2001 Sep 17;12(13):inside back cover

Abstract

Using dual-labeling in situ hybridization histochemistry, the neurotransmitter expression of immune-responsive neurons in the pontine parabrachial nucleus, a major relay for interoceptive information, was investigated. Intravenous injection of bacterial wall lipopolysaccharide resulted in dense c-fos mRNA expression in the external lateral parabrachial nucleus, and a majority of the c-fos expressing cells also expressed calcitonin gene-related peptide (CGRP) mRNA. In contrast CGRP-positive cells in the adjoining external medial subnucleus were c-fos negative. Taken together with previous hodological and behavioral studies, these data suggest that CGRPergic parabrachial neurons may mediate lipopolysaccharide-induced anorexia by means of their projection to central nucleus of the amygdala.

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