An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway - PubMed (original) (raw)

. 2001 Sep 14;293(5537):2111-4.

doi: 10.1126/science.1061964. Epub 2001 Aug 16.

Affiliations

• PMID: 11509691
• DOI: 10.1126/science.1061964

An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway

B Schiemann et al. Science. 2001.

Abstract

The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

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Comment in

• Immunology. Long live the mature B cell--a baffling mystery resolved.
  Waldschmidt TJ, Noelle RJ. Waldschmidt TJ, et al. Science. 2001 Sep 14;293(5537):2012-3. doi: 10.1126/science.1065591. Science. 2001. PMID: 11557866

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