Ectopic lymphoid organogenesis: a fast track for autoimmunity - PubMed (original) (raw)

Review

Ectopic lymphoid organogenesis: a fast track for autoimmunity

C M Weyand et al. Am J Pathol. 2001 Sep.

No abstract available

PubMed Disclaimer

Figures

Figure 1.

Emergent pathways of lymphoid organization in autoimmune disease. We propose that distinct pathways of lymphoid neogenesis can be set in place by an antigen-driven immune response occurring in extranodal tissue. Selection of the pathway depends on modulating host factors, including the aberrant expression of cytokines/chemokines and the recruitment of cellular components necessary for certain types of lymphoid microstructures. The organization of the lymphoid infiltrate may confer capabilities that fundamentally affect the quality and quantity of the pathological immune response and thus have direct implications in accelerating the breakdown in self-tolerance.

Comment on

• Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers.
  Armengol MP, Juan M, Lucas-Martín A, Fernández-Figueras MT, Jaraquemada D, Gallart T, Pujol-Borrell R. Armengol MP, et al. Am J Pathol. 2001 Sep;159(3):861-73. doi: 10.1016/S0002-9440(10)61762-2. Am J Pathol. 2001. PMID: 11549579 Free PMC article.

Similar articles

• Ectopic lymphoid-like structures in infection, cancer and autoimmunity.
  Pitzalis C, Jones GW, Bombardieri M, Jones SA. Pitzalis C, et al. Nat Rev Immunol. 2014 Jul;14(7):447-62. doi: 10.1038/nri3700. Epub 2014 Jun 20. Nat Rev Immunol. 2014. PMID: 24948366 Review.
• [Autoimmunization symptoms in thyroid diseases].
  Wegier A, Głab S, Wróblewska I, Nowak M, Feluś E. Wegier A, et al. Pol Tyg Lek. 1978 Dec 25;33(52):2011-3. Pol Tyg Lek. 1978. PMID: 366580 Review. Polish. No abstract available.
• Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers.
  Armengol MP, Juan M, Lucas-Martín A, Fernández-Figueras MT, Jaraquemada D, Gallart T, Pujol-Borrell R. Armengol MP, et al. Am J Pathol. 2001 Sep;159(3):861-73. doi: 10.1016/S0002-9440(10)61762-2. Am J Pathol. 2001. PMID: 11549579 Free PMC article.
• Discerning the kinetics of autoimmune manifestations in a model of Sjögren's syndrome.
  Karnell JL, Mahmoud TI, Herbst R, Ettinger R. Karnell JL, et al. Mol Immunol. 2014 Dec;62(2):277-82. doi: 10.1016/j.molimm.2014.05.006. Epub 2014 Jun 5. Mol Immunol. 2014. PMID: 24907930
• Immunology. Autoreactive B cells migrate into T cell territory.
  Fu YX, Storb U. Fu YX, et al. Science. 2002 Sep 20;297(5589):2006-8. doi: 10.1126/science.1077011. Science. 2002. PMID: 12242429 No abstract available.

Cited by

• The Role of Podoplanin in the Immune System and Inflammation.
  Zhang Z, Zhang N, Yu J, Xu W, Gao J, Lv X, Wen Z. Zhang Z, et al. J Inflamm Res. 2022 Jun 17;15:3561-3572. doi: 10.2147/JIR.S366620. eCollection 2022. J Inflamm Res. 2022. PMID: 35747250 Free PMC article. Review.
• Paving the way towards an effective treatment for multiple sclerosis: advances in cell therapy.
  Mansilla MJ, Presas-Rodríguez S, Teniente-Serra A, González-Larreategui I, Quirant-Sánchez B, Fondelli F, Djedovic N, Iwaszkiewicz-Grześ D, Chwojnicki K, Miljković Đ, Trzonkowski P, Ramo-Tello C, Martínez-Cáceres EM. Mansilla MJ, et al. Cell Mol Immunol. 2021 Jun;18(6):1353-1374. doi: 10.1038/s41423-020-00618-z. Epub 2021 May 6. Cell Mol Immunol. 2021. PMID: 33958746 Free PMC article. Review.
• Novel histopathologic predictors for renal outcomes in crescentic glomerulonephritis.
  Lim JH, Han MH, Kim YJ, Jeon Y, Jung HY, Choi JY, Cho JH, Kim CD, Kim YL, Lee H, Kim DK, Moon KC, Park SH. Lim JH, et al. PLoS One. 2020 Jul 27;15(7):e0236051. doi: 10.1371/journal.pone.0236051. eCollection 2020. PLoS One. 2020. PMID: 32716952 Free PMC article.
• Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy.
  Lin L, Hu X, Zhang H, Hu H. Lin L, et al. Front Immunol. 2019 Jun 20;10:1398. doi: 10.3389/fimmu.2019.01398. eCollection 2019. Front Immunol. 2019. PMID: 31281318 Free PMC article. Review.
• Podoplanin in Inflammation and Cancer.
  Quintanilla M, Montero-Montero L, Renart J, Martín-Villar E. Quintanilla M, et al. Int J Mol Sci. 2019 Feb 6;20(3):707. doi: 10.3390/ijms20030707. Int J Mol Sci. 2019. PMID: 30736372 Free PMC article. Review.

References

1. 1. Armengol MP, Juan M, Lucas-Martin A, Fernández-Figueras MT, Jaraquemada D, Gallart T, Pujol-Borrell R: Thyroid autoimmune disease: demonstration of thyroid-antigen specific B cells and recombination-activating gene expression in chemokine-containing intrathyroidal active germinal centers. Am J Pathol 2001, 159:861-873 - PMC - PubMed
2. 1. MacLennan IC: Germinal centers. Annu Rev Immunol 1994, 12:117-139 - PubMed
3. 1. McHeyzer-Williams LJ, Driver DJ, Mc-Heyzer-Williams MG: Germinal center reaction. Curr Opin Hematol 2001, 8:52-59 - PubMed
4. 1. Ruddle NH: Lymphoid neo-organogenesis: lymphotoxin’s role in inflammation and development. Immunol Res 1999, 19:119-125 - PubMed
5. 1. Knecht H, Saremaslani P, Hedinger C: Immunohistological findings in Hashimoto’s thyroiditis, focal lymphocytic thyroiditis and thyroiditis de Quervain. Comparative study. Virchows Arch A Pathol Anat Histol 1981, 393:215-231 - PubMed

Publication types

MeSH terms

Substances

Grants and funding

• R01 AR41974/AR/NIAMS NIH HHS/United States
• R01 AR042527/AR/NIAMS NIH HHS/United States
• R01 AI044142/AI/NIAID NIH HHS/United States
• R01 AR041974/AR/NIAMS NIH HHS/United States
• R01 AR42527/AR/NIAMS NIH HHS/United States
• R01 AI44142/AI/NIAID NIH HHS/United States

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations

• Medical

  • MedlinePlus Health Information