Immunotherapy through TCR gene transfer - PubMed (original) (raw)
Immunotherapy through TCR gene transfer
H W Kessels et al. Nat Immunol. 2001 Oct.
Abstract
The antigen specificity of T lymphocytes is dictated solely by the T cell receptor (TCR) alpha and beta chains. Consequently, genetic transfer of TCR chains may be an appealing strategy with which to impose a desirable virus- or tumor-antigen specificity onto cytotoxic or helper T cell populations. We describe here the genetic introduction of a virus-specific TCR into peripheral T cells in a mouse model system. These experiments showed that T cells redirected by TCR gene transfer expanded upon viral infection of mice and efficiently homed to effector sites. In this setting, TCR gene transfer was not associated with any significant autoimmune pathology. In addition, small numbers of TCR-transduced T cells promoted the rejection of antigen-expressing tumors in vivo. These data suggest that the redirection of T cells by TCR gene transfer is a viable strategy for the rapid induction of virus- or tumor-specific immunity.
Comment in
- Redirecting T cell specificity by TCR gene transfer.
Moss PA. Moss PA. Nat Immunol. 2001 Oct;2(10):900-1. doi: 10.1038/ni1001-900. Nat Immunol. 2001. PMID: 11577342 No abstract available.
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