Systemic lupus erythematosus and antiphospholipid syndrome in children and adolescents - PubMed (original) (raw)
Review
Systemic lupus erythematosus and antiphospholipid syndrome in children and adolescents
T Lee et al. Curr Opin Rheumatol. 2001 Sep.
Abstract
Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) can be associated with significant morbidity in children and adolescents. Renal involvement in SLE appears to be more severe and more frequent in the pediatric age group, with the major predictors for poor outcome being the severity of histopathologic lesions, severity of renal impairment at diagnosis, and hypertension. In addition to currently recognized cardiovascular and pulmonary involvement, accelerated atherosclerosis is of increasing concern in young individuals with SLE, because of both disease effects and medication usage. Neuropsychiatric SLE seen in childhood ranges from subtle cognitive dysfunction to severe central nervous system involvement; however, there is controversy over the value of different diagnostic studies. APS in children may be associated with SLE, idiopathic, or associated with viral infections. Systemic anticoagulation is recommended for patients with thrombotic events, but long-term management has not been well studied in children.
Similar articles
- Primary antiphospholipid syndrome as the forerunner of systemic lupus erythematosus.
Tarr T, Lakos G, Bhattoa HP, Szegedi G, Shoenfeld Y, Kiss E. Tarr T, et al. Lupus. 2007;16(5):324-8. doi: 10.1177/0961203307077993. Lupus. 2007. PMID: 17576733 - Clinical development in the management of lupus in the neonate, child, and adolescent.
Szer IS. Szer IS. Curr Opin Rheumatol. 1998 Sep;10(5):431-4. doi: 10.1097/00002281-199809000-00006. Curr Opin Rheumatol. 1998. PMID: 9746858 Review. - [Systemic lupus erythematosus and antiphospholipid syndrome - diagnostic and therapeutic problems].
Zdrojewski Z. Zdrojewski Z. Wiad Lek. 2018;71(1 pt 1):40-46. Wiad Lek. 2018. PMID: 29558350 Review. Polish. - Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome.
Avcin T, Silverman ED. Avcin T, et al. Lupus. 2007;16(8):627-33. doi: 10.1177/0961203307079036. Lupus. 2007. PMID: 17711899 Review. - Zonal cortical scarring and tubular thyroidization in kidney biopsies of patients with SLE-histologic indicator for antiphospholipid antibodies.
Shah R, Brodsky SV, Hebert L, Rovin BH, Nadasdy T, Satoskar AA. Shah R, et al. Lupus. 2018 Dec;27(14):2236-2244. doi: 10.1177/0961203318809177. Epub 2018 Nov 7. Lupus. 2018. PMID: 30403144
Cited by
- Biomarkers for CNS involvement in pediatric lupus.
Rubinstein TB, Putterman C, Goilav B. Rubinstein TB, et al. Biomark Med. 2015;9(6):545-58. doi: 10.2217/bmm.15.26. Biomark Med. 2015. PMID: 26079959 Free PMC article. Review. - [Connective tissue diseases in childhood].
Gensch K, Gudowius S, Niehues T, Kuhn A. Gensch K, et al. Hautarzt. 2005 Oct;56(10):925-36. doi: 10.1007/s00105-005-1016-4. Hautarzt. 2005. PMID: 16160808 Review. German. - Antiphospholipid antibodies in pediatrics.
Quintero-Del-Rio AI. Quintero-Del-Rio AI. Curr Rheumatol Rep. 2002 Oct;4(5):387-91. doi: 10.1007/s11926-002-0082-1. Curr Rheumatol Rep. 2002. PMID: 12217242 Review. - Renal infarction in a child with systemic lupus erythematosus.
Kuzmanovska DB, Sahpazova EM, Grujovska SJ, Trajkovski Z. Kuzmanovska DB, et al. Pediatr Nephrol. 2004 Jun;19(6):685-7. doi: 10.1007/s00467-004-1454-8. Epub 2004 Apr 3. Pediatr Nephrol. 2004. PMID: 15064940 - Predictors for neuropsychiatric development in Chinese adolescents with systemic lupus erythematosus.
Dong J, Li H, Wang JB, Yao Y, Yang QR. Dong J, et al. Rheumatol Int. 2012 Sep;32(9):2681-6. doi: 10.1007/s00296-011-2042-4. Epub 2011 Jul 26. Rheumatol Int. 2012. PMID: 21789612
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous