Increased p53 mutation frequency during tumor progression--results from a breast cancer cohort - PubMed (original) (raw)

Comparative Study

. 2001 Nov 15;61(22):8317-21.

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• PMID: 11719465

Comparative Study

Increased p53 mutation frequency during tumor progression--results from a breast cancer cohort

T Norberg et al. Cancer Res. 2001.

Abstract

The mutational patterns of the p53 gene for exons 4-9 were analyzed in 30 recurring tumors compared with the p53 status of the corresponding 30 primary breast cancers. The prevalence of p53 mutations was higher, although not statistically significant (P = 0.07), in the evaluable recurring tumors compared with the corresponding primaries, 12 of 29 (41%) versus 7 of 30 (23%). Twenty-one of the patients had unchanged p53 mutation status in the recurring compared with the primary tumors, whereas 8 had an altered mutational status or pattern in the sequential tumor. These findings indicate that p53 mutations may be an important factor for tumor progression in human breast cancer.

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