Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion - PubMed (original) (raw)
Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion
R Arens et al. Immunity. 2001 Nov.
Free article
Abstract
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal. Mice expressing constitutive CD70 on B cells had higher peripheral T cell numbers that showed increased differentiation toward effector-type T cells. B cell numbers in CD70 transgenic (TG) mice progressively decreased in primary and secondary lymphoid organs. This B cell depletion was caused by CD27-induced production of IFNgamma in T cells. We conclude that apart from its role in controlling the size of the activated T cell pool, CD27 ligation contributes to immunity by facilitating effector T cell differentiation.
Similar articles
- CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
Al Sayed MF, Ruckstuhl CA, Hilmenyuk T, Claus C, Bourquin JP, Bornhauser BC, Radpour R, Riether C, Ochsenbein AF. Al Sayed MF, et al. Blood. 2017 Jul 20;130(3):297-309. doi: 10.1182/blood-2016-12-756585. Epub 2017 May 11. Blood. 2017. PMID: 28495792 - Plasma cell generation from B-lymphocytes via CD27/CD70 interaction.
Agematsu K, Hokibara S, Nagumo H, Shinozaki K, Yamada S, Komiyama A. Agematsu K, et al. Leuk Lymphoma. 1999 Oct;35(3-4):219-25. doi: 10.3109/10428199909145724. Leuk Lymphoma. 1999. PMID: 10706444 Review. - CD27-CD70 interactions regulate B-cell activation by T cells.
Kobata T, Jacquot S, Kozlowski S, Agematsu K, Schlossman SF, Morimoto C. Kobata T, et al. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11249-53. doi: 10.1073/pnas.92.24.11249. Proc Natl Acad Sci U S A. 1995. PMID: 7479974 Free PMC article. - Involvement of CD70-CD27 interactions in the induction of experimental autoimmune encephalomyelitis.
Nakajima A, Oshima H, Nohara C, Morimoto S, Yoshino S, Kobata T, Yagita H, Okumura K. Nakajima A, et al. J Neuroimmunol. 2000 Sep 22;109(2):188-96. doi: 10.1016/s0165-5728(00)00324-6. J Neuroimmunol. 2000. PMID: 10996221 - CD27/CD70 interactions regulate T dependent B cell differentiation.
Jacquot S. Jacquot S. Immunol Res. 2000;21(1):23-30. doi: 10.1385/IR:21:1:23. Immunol Res. 2000. PMID: 10803880 Review.
Cited by
- Cellular indexing of transcriptomes and epitopes (CITE-Seq) in hidradenitis suppurativa identifies dysregulated cell types in peripheral blood and facilitates diagnosis via machine learning.
Kumar S, Orcales F, Shih BB, Fang X, Yin C, Yates A, Dimitrion P, Neuhaus I, Johnson C, Adrianto I, Wiala A, Hamzavi I, Zhou L, Naik H, Posch C, Mi QS, Liao W. Kumar S, et al. Res Sq [Preprint]. 2024 Sep 9:rs.3.rs-4791069. doi: 10.21203/rs.3.rs-4791069/v1. Res Sq. 2024. PMID: 39315268 Free PMC article. Preprint. - Azithromycin targets the CD27 pathway to modulate CD27hi T-lymphocyte expansion and type-1 effector phenotype.
Ansari AW, Jayakumar MN, Ahmad F, Venkatachalam T, Salameh L, Unnikannan H, Raheed T, Mohammed AK, Mahboub B, Al-Ramadi BK, Hamid Q, Steinhoff M, Hamoudi R. Ansari AW, et al. Front Immunol. 2024 Aug 15;15:1447625. doi: 10.3389/fimmu.2024.1447625. eCollection 2024. Front Immunol. 2024. PMID: 39211048 Free PMC article. - Transcriptional reprogramming via signaling domains of CD2, CD28, and 4-1BB.
De Sousa Linhares A, Sharma S, Steinberger P, Leitner J. De Sousa Linhares A, et al. iScience. 2024 Feb 19;27(3):109267. doi: 10.1016/j.isci.2024.109267. eCollection 2024 Mar 15. iScience. 2024. PMID: 38455974 Free PMC article. - Anti-PD-L1-Based Bispecific Antibodies Targeting Co-Inhibitory and Co-Stimulatory Molecules for Cancer Immunotherapy.
Geng Q, Jiao P. Geng Q, et al. Molecules. 2024 Jan 17;29(2):454. doi: 10.3390/molecules29020454. Molecules. 2024. PMID: 38257366 Free PMC article. Review. - The effect of edible bird's nests on the expression of MHC-II and costimulatory molecules of C57BL/6 mouse splenocytes.
Dobutr T, Jangpromma N, Patramanon R, Daduang J, Klaynongsruang S, Poopornchai S, Yabe T, Daduang S. Dobutr T, et al. Biochem Biophys Rep. 2023 Aug 25;35:101534. doi: 10.1016/j.bbrep.2023.101534. eCollection 2023 Sep. Biochem Biophys Rep. 2023. PMID: 37671389 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous