Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer - PubMed (original) (raw)
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
J M Piek et al. J Pathol. 2001 Nov.
Abstract
The aim of this study was to investigate the occurrence of (pre)neoplastic lesions in overtly normal Fallopian tubes from women predisposed to developing ovarian carcinoma. The presence of (pre)neoplastic lesions was scored in histological specimens from 12 women with a genetically determined predisposition for ovarian cancer, of whom seven tested positive for a germline BRCA1 mutation. A control group included 13 women. Immunohistochemistry was used to determine the expression of p21, p27, p53, cyclin A, cyclin D1, bcl-2, Ki67, HER-2/neu, and the oestrogen and progesterone receptors. Loss of heterozygosity (LOH) analysis on the BRCA1 locus was also assessed on dysplastic tissue by PCR studies. Of the 12 women with a predisposition for ovarian cancer, six showed dysplasia, including one case of severe dysplasia. Five harboured hyperplastic lesions and in one woman no histological aberrations were found in the Fallopian tube. No hyperplastic, dysplastic or neoplastic lesions were detected in the Fallopian tubes of control subjects. In the cases studied, morphologically normal tubal epithelium contained a higher proportion of Ki67-expressing cells (p=0.005) and lower fractions of cells expressing p21 (p<0.0001) and p27 (p=0.006) than in the control group. Even higher fractions of proliferating cells were found in dysplastic areas (p=0.07) and accumulation of p53 was observed in the severely dysplastic lesion. Expression patterns of other proteins studied, including the hormone receptors, were similar in cases and controls. One subject, a germline BRCA1 mutation carrier, showed loss of the wild-type BRCA1 allele in the severely dysplastic lesion. In conclusion, the Fallopian tubes of women predisposed to developing ovarian cancer frequently harbour dysplastic changes, accompanied by changes in cell-cycle and apoptosis-related proteins, indicating an increased risk of developing tubal cancer.
Copyright 2001 John Wiley & Sons, Ltd.
Similar articles
- BRCA1 and p53 protein expression in cultured ovarian surface epithelial cells derived from women with and without a BRCA1 germline mutation.
Piek JM, Dorsman JC, Massuger LF, Ansink AC, Weegenaar J, Shvarts A, Kenemans P, Verheijen RH. Piek JM, et al. Arch Gynecol Obstet. 2006 Oct;274(6):327-31. doi: 10.1007/s00404-006-0200-9. Epub 2006 Jul 7. Arch Gynecol Obstet. 2006. PMID: 16826413 - Expression of differentiation and proliferation related proteins in epithelium of prophylactically removed ovaries from women with a hereditary female adnexal cancer predisposition.
Piek JM, Verheijen RH, Menko FH, Jongsma AP, Weegenaar J, Gille JJ, Pals G, Kenemans P, van Diest PJ. Piek JM, et al. Histopathology. 2003 Jul;43(1):26-32. doi: 10.1046/j.1365-2559.2003.01654.x. Histopathology. 2003. PMID: 12823709 - Expression of cell cycle regulatory proteins in ovaries prophylactically removed from Jewish Ashkenazi BRCA1 and BRCA2 mutation carriers: correlation with histopathology.
Kerner R, Sabo E, Gershoni-Baruch R, Beck D, Ben-Izhak O. Kerner R, et al. Gynecol Oncol. 2005 Nov;99(2):367-75. doi: 10.1016/j.ygyno.2005.06.041. Epub 2005 Jul 26. Gynecol Oncol. 2005. PMID: 16051332 - The distal fallopian tube: a new model for pelvic serous carcinogenesis.
Crum CP, Drapkin R, Miron A, Ince TA, Muto M, Kindelberger DW, Lee Y. Crum CP, et al. Curr Opin Obstet Gynecol. 2007 Feb;19(1):3-9. doi: 10.1097/GCO.0b013e328011a21f. Curr Opin Obstet Gynecol. 2007. PMID: 17218844 Review. - A pathologist's road map to benign, precancerous, and malignant intraepithelial proliferations in the fallopian tube.
Mehrad M, Ning G, Chen EY, Mehra KK, Crum CP. Mehrad M, et al. Adv Anat Pathol. 2010 Sep;17(5):293-302. doi: 10.1097/PAP.0b013e3181ecdee1. Adv Anat Pathol. 2010. PMID: 20733351 Review.
Cited by
- Technical challenges and limitations of current mouse models of ovarian cancer.
Garson K, Gamwell LF, Pitre EM, Vanderhyden BC. Garson K, et al. J Ovarian Res. 2012 Nov 29;5(1):39. doi: 10.1186/1757-2215-5-39. J Ovarian Res. 2012. PMID: 23190474 Free PMC article. - DNA Methylome Analyses Implicate Fallopian Tube Epithelia as the Origin for High-Grade Serous Ovarian Cancer.
Klinkebiel D, Zhang W, Akers SN, Odunsi K, Karpf AR. Klinkebiel D, et al. Mol Cancer Res. 2016 Sep;14(9):787-94. doi: 10.1158/1541-7786.MCR-16-0097. Epub 2016 Jun 3. Mol Cancer Res. 2016. PMID: 27259716 Free PMC article. - Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities.
Koopmans T, Rinkevich Y. Koopmans T, et al. Commun Biol. 2018 Oct 16;1:170. doi: 10.1038/s42003-018-0180-x. eCollection 2018. Commun Biol. 2018. PMID: 30345394 Free PMC article. Review. - Methylation and ovarian cancer: Can DNA methylation be of diagnostic use?
Hentze JL, Høgdall CK, Høgdall EV. Hentze JL, et al. Mol Clin Oncol. 2019 Mar;10(3):323-330. doi: 10.3892/mco.2019.1800. Epub 2019 Jan 11. Mol Clin Oncol. 2019. PMID: 30847169 Free PMC article. Review. - New approaches in ovarian cancer based on genetics and carcinogenesis hypotheses (Review).
Mogos RA, Popovici R, Tanase AE, Calistru T, Popovici P, Grigore M, Carauleanu A. Mogos RA, et al. Exp Ther Med. 2022 Jun;23(6):423. doi: 10.3892/etm.2022.11351. Epub 2022 May 4. Exp Ther Med. 2022. PMID: 35607380 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous