Transforming growth factor-beta in T-cell biology - PubMed (original) (raw)
Review
doi: 10.1038/nri704.
Affiliations
- PMID: 11905837
- DOI: 10.1038/nri704
Review
Transforming growth factor-beta in T-cell biology
Leonid Gorelik et al. Nat Rev Immunol. 2002 Jan.
Abstract
Strict control of T-cell homeostasis is required to permit normal immune responses and prevent undesirable self-targeted responses. Transforming growth factor-beta (TGF-beta) has been shown to have an essential role in that regulation. Owing to its broad expression, and inhibitory effects on multiple cell types of the immune system, TGF-beta regulation is complex. Through advances in cell-specific targeting of TGF-beta signalling in vivo, the role of TGF-beta in T-cell regulation has become clearer. Recent in vitro studies provide a better understanding of how TGF-beta regulates T-cell homeostasis, through multiple mechanisms involving numerous cell types.
Similar articles
- TGFbeta-mediated immunoregulation.
Peng Y, Gorelik L, Laouar Y, Li MO, Flavell RA. Peng Y, et al. Ernst Schering Res Found Workshop. 2006;(56):155-60. Ernst Schering Res Found Workshop. 2006. PMID: 16329651 - TGFbeta signalling in control of T-cell-mediated self-reactivity.
Rubtsov YP, Rudensky AY. Rubtsov YP, et al. Nat Rev Immunol. 2007 Jun;7(6):443-53. doi: 10.1038/nri2095. Nat Rev Immunol. 2007. PMID: 17525753 Review. - Transforming growth factor-beta: an important role in CD4+CD25+ regulatory T cells and immune tolerance.
Zhang L, Yi H, Xia XP, Zhao Y. Zhang L, et al. Autoimmunity. 2006 Jun;39(4):269-76. doi: 10.1080/08916930600753903. Autoimmunity. 2006. PMID: 16891215 Review. - TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia.
Letterio JJ. Letterio JJ. Oncogene. 2005 Aug 29;24(37):5701-12. doi: 10.1038/sj.onc.1208922. Oncogene. 2005. PMID: 16123803 Review. - TGF-beta as a promising option in the treatment of multiple sclerosis.
Mirshafiey A, Mohsenzadegan M. Mirshafiey A, et al. Neuropharmacology. 2009 May-Jun;56(6-7):929-36. doi: 10.1016/j.neuropharm.2009.02.007. Epub 2009 Mar 11. Neuropharmacology. 2009. PMID: 19285095 Review.
Cited by
- MicroRNAs are enriched at COVID-19 genomic risk regions, and their blood levels correlate with the COVID-19 prognosis of cancer patients infected by SARS-CoV-2.
Anfossi S, Darbaniyan F, Quinlan J, Calin S, Shimizu M, Chen M, Rausseo P, Winters M, Bogatenkova E, Do KA, Martinez I, Li Z, Antal L, Olariu TR, Wistuba I, Calin GA. Anfossi S, et al. Mol Cancer. 2024 Oct 21;23(1):235. doi: 10.1186/s12943-024-02094-9. Mol Cancer. 2024. PMID: 39434078 Free PMC article. - Beta cells deficient for Renalase counteract autoimmunity by shaping natural killer cell activity.
Bode K, Wei S, Gruber I, Li J, Kissler S, Yi P. Bode K, et al. Front Immunol. 2024 Jun 4;15:1403752. doi: 10.3389/fimmu.2024.1403752. eCollection 2024. Front Immunol. 2024. PMID: 38975343 Free PMC article. - Sex differences and immune correlates of Long COVID development, persistence, and resolution.
Hamlin RE, Pienkos SM, Chan L, Stabile MA, Pinedo K, Rao M, Grant P, Bonilla H, Holubar M, Singh U, Jacobson KB, Jagannathan P, Maldonado Y, Holmes SP, Subramanian A, Blish CA. Hamlin RE, et al. bioRxiv [Preprint]. 2024 Jun 19:2024.06.18.599612. doi: 10.1101/2024.06.18.599612. bioRxiv. 2024. PMID: 38948732 Free PMC article. Updated. Preprint. - Construction of immune-related gene pairs signature to predict the overall survival of multiple myeloma patients based on whole bone marrow gene expression profiling.
Jafari-Raddani F, Davoodi-Moghaddam Z, Bashash D. Jafari-Raddani F, et al. Mol Genet Genomics. 2024 Apr 22;299(1):47. doi: 10.1007/s00438-024-02140-7. Mol Genet Genomics. 2024. PMID: 38649532 - TGF-β mRNA levels in circulating extracellular vesicles are associated with response to anti-PD1 treatment in metastatic melanoma.
Crucitta S, Cucchiara F, Marconcini R, Bulleri A, Manacorda S, Capuano A, Cioni D, Nuzzo A, de Jonge E, Mathjissen RHJ, Neri E, van Schaik RHN, Fogli S, Danesi R, Del Re M. Crucitta S, et al. Front Mol Biosci. 2024 Apr 3;11:1288677. doi: 10.3389/fmolb.2024.1288677. eCollection 2024. Front Mol Biosci. 2024. PMID: 38633217 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources