Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis - PubMed (original) (raw)

Guy Hermans, Rosetta Pedotti, Andrea Brendolan, Eric Schadt, Hideki Garren, Annette Langer-Gould, Samuel Strober, Barbara Cannella, John Allard, Paul Klonowski, Angela Austin, Nagin Lad, Naftali Kaminski, Stephen J Galli, Jorge R Oksenberg, Cedric S Raine, Renu Heller, Lawrence Steinman

Affiliations

PMID: 11984595
DOI: 10.1038/nm0502-500

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Christopher Lock et al. Nat Med. 2002 May.

Abstract

Microarray analysis of multiple sclerosis (MS) lesions obtained at autopsy revealed increased transcripts of genes encoding inflammatory cytokines, particularly interleukin-6 and -17, interferon-gamma and associated downstream pathways. Comparison of two poles of MS pathology--acute lesions with inflammation versus 'silent' lesions without inflammation--revealed differentially transcribed genes. Some products of these genes were chosen as targets for therapy of experimental autoimmune encephalomyelitis (EAE) in mice. Granulocyte colony-stimulating factor is upregulated in acute, but not in chronic, MS lesions, and the effect on ameliorating EAE is more pronounced in the acute phase, in contrast to knocking out the immunoglobulin Fc receptor common gamma chain where the effect is greatest on chronic disease. These results in EAE corroborate the microarray studies on MS lesions. Large-scale analysis of transcripts in MS lesions elucidates new aspects of pathology and opens possibilities for therapy.

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Comment in

An array of possibilities for multiple sclerosis.
Tompkins SM, Miller SD. Tompkins SM, et al. Nat Med. 2002 May;8(5):451-3. doi: 10.1038/nm0502-451. Nat Med. 2002. PMID: 11984584 No abstract available.

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis - PubMed (original) (raw)