Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus - PubMed (original) (raw)
Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus
Lixin Wang et al. Neurosci Lett. 2002.
Abstract
Ghrelin, a peptide isolated from the rat stomach, is the endogenous ligand of the growth hormone-secretagogue receptor and also known to have orexigenic effect. We examined the influence of intraperitoneal (i.p.) injection of ghrelin on food intake and brain neuronal activity in freely fed mice. Ghrelin (3, 10 or 30 microg/mouse) dose-dependently increased food intake by 0.8-, 1.6- and 2.6-fold, respectively, at 30 min post injection. Ghrelin (10 microg/mouse) induces Fos expression selectively in the ventromedial part of the hypothalamic arcuate nucleus (Arc). No change in Fos expression was observed in other hypothalamic and hindbrain nuclei. About 90% of the Fos-positive neurons in the Arc expressed neuropeptide Y (NPY) messenger RNA. These data indicate that NPY neurons in the Arc are likely the primary target mediating i.p. ghrelin induced orexigenic effect.
Similar articles
- Diet-derived nutrients mediate the inhibition of hypothalamic NPY neurons in the arcuate nucleus of mice during refeeding.
Becskei C, Lutz TA, Riediger T. Becskei C, et al. Am J Physiol Regul Integr Comp Physiol. 2009 Jul;297(1):R100-10. doi: 10.1152/ajpregu.91014.2008. Epub 2009 Apr 29. Am J Physiol Regul Integr Comp Physiol. 2009. PMID: 19403857 - Bombesin, but not amylin, blocks the orexigenic effect of peripheral ghrelin.
Kobelt P, Goebel M, Stengel A, Schmidtmann M, van der Voort IR, Tebbe JJ, Veh RW, Klapp BF, Wiedenmann B, Wang L, Taché Y, Mönnikes H. Kobelt P, et al. Am J Physiol Regul Integr Comp Physiol. 2006 Oct;291(4):R903-13. doi: 10.1152/ajpregu.00681.2005. Epub 2006 Apr 27. Am J Physiol Regul Integr Comp Physiol. 2006. PMID: 16644908 - Peptide YY directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression.
Riediger T, Bothe C, Becskei C, Lutz TA. Riediger T, et al. Neuroendocrinology. 2004;79(6):317-26. doi: 10.1159/000079842. Epub 2004 Jul 15. Neuroendocrinology. 2004. PMID: 15256809 - Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract.
Kojima M, Kangawa K. Kojima M, et al. Curr Opin Pharmacol. 2002 Dec;2(6):665-8. doi: 10.1016/s1471-4892(02)00220-5. Curr Opin Pharmacol. 2002. PMID: 12482728 Review. - Functions of Ghrelin in Brain, Gut and Liver.
Stasi C, Milani S. Stasi C, et al. CNS Neurol Disord Drug Targets. 2016;15(8):956-963. doi: 10.2174/1871527315666160709203525. CNS Neurol Disord Drug Targets. 2016. PMID: 27396373 Review.
Cited by
- Yin and Yang - the Gastric X/A-like Cell as Possible Dual Regulator of Food Intake.
Stengel A, Taché Y. Stengel A, et al. J Neurogastroenterol Motil. 2012 Apr;18(2):138-49. doi: 10.5056/jnm.2012.18.2.138. Epub 2012 Apr 9. J Neurogastroenterol Motil. 2012. PMID: 22523723 Free PMC article. - Characterization of extracellular spike waveforms recorded in wallaby primary visual cortex.
Jung YJ, Sun SH, Almasi A, Yunzab M, Meffin H, Ibbotson MR. Jung YJ, et al. Front Neurosci. 2023 Sep 8;17:1244952. doi: 10.3389/fnins.2023.1244952. eCollection 2023. Front Neurosci. 2023. PMID: 37746137 Free PMC article. Review. - Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents.
Kobelt P, Wisser AS, Stengel A, Goebel M, Bannert N, Gourcerol G, Inhoff T, Noetzel S, Wiedenmann B, Klapp BF, Taché Y, Mönnikes H. Kobelt P, et al. Peptides. 2008 Jun;29(6):1018-27. doi: 10.1016/j.peptides.2008.01.020. Epub 2008 Feb 7. Peptides. 2008. PMID: 18342400 Free PMC article. - Acylation type determines ghrelin's effects on energy homeostasis in rodents.
Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Heppner KM, et al. Endocrinology. 2012 Oct;153(10):4687-95. doi: 10.1210/en.2012-1194. Epub 2012 Aug 3. Endocrinology. 2012. PMID: 22865372 Free PMC article. - Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.
Wang Q, Liu C, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM. Wang Q, et al. Mol Metab. 2013 Oct 17;3(1):64-72. doi: 10.1016/j.molmet.2013.10.001. eCollection 2014 Feb. Mol Metab. 2013. PMID: 24567905 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous