Expression of G1 phase cyclins in human gastric cancer and gastric mucosa of first-degree relatives - PubMed (original) (raw)

. 2002 Jun;47(6):1248-56.

doi: 10.1023/a:1015358127751.

Jun Yu, Matthias Ebert, Daniel Szokodi, Michael Vieth, Eberhard Kuhlisch, Rene Buchcik, Wolfgang Schimmin, Ursula Wehrmann, Peter Malfertheiner, Gerhard Ehninger, Ekkehard Bayerdörffer, Manfred Stolte

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Expression of G1 phase cyclins in human gastric cancer and gastric mucosa of first-degree relatives

Stephan Miehlke et al. Dig Dis Sci. 2002 Jun.

Abstract

The aim of this study was to investigate the expression of D-type cyclins and cyclin E in gastric cancer patients (N = 34), in healthy first-degree relatives of gastric cancer patients (N = 29), and in control subjects (N = 18). Expression of cyclins D1, D2, D3, and E was determined by RT-PCR. Localization of cyclin expression was determined by immunohistochemistry. Expression of cyclins D2, D3, and E was more frequently detected in tumor tissue compared with tumor-free gastric mucosa (P < 0.05) and was associated with the presence of intestinal metaplasia. In contrast, cyclin D1 was frequently expressed in both tumor- and tumor-free tissue. Cyclin D3 expression was more frequently detected in the antrum mucosa of first-degree relatives compared to controls (P < 0.01) and was associated with the presence of Helicobacter pylori. Our data suggest that deregulation of G1 phase cyclins may play a role in gastric carcinogenesis, and may point to the presence of molecular alterations in individuals at an increased risk for gastric cancer.

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