Telomerase beyond telomeres - PubMed (original) (raw)

Review

doi: 10.1038/nrc862.

Affiliations

• PMID: 12154355
• DOI: 10.1038/nrc862

Review

Telomerase beyond telomeres

María A Blasco. Nat Rev Cancer. 2002 Aug.

Abstract

The role of telomerase in actively proliferating cells is assumed to be restricted to maintaining of telomeres above a minimum-length threshold, thereby preventing telomere exhaustion and chromosomal instability. However, forced telomerase expression in cells and mice with normal-length telomeres has shown that telomerase promotes growth and survival in a manner that is uncoupled from net telomere lengthening. These findings imply that telomerase might have a fundamental role in tumour growth and survival, even at stages when telomeres are sufficiently long.

PubMed Disclaimer

Similar articles

• New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin.
  Chan SW, Blackburn EH. Chan SW, et al. Oncogene. 2002 Jan 21;21(4):553-63. doi: 10.1038/sj.onc.1205082. Oncogene. 2002. PMID: 11850780 Review.
• Telomere Dysfunction, Chromosomal Instability and Cancer.
  Meena J, Rudolph KL, Günes C. Meena J, et al. Recent Results Cancer Res. 2015;200:61-79. doi: 10.1007/978-3-319-20291-4_3. Recent Results Cancer Res. 2015. PMID: 26376872 Review.
• Dysfunctional telomeres promote genomic instability and metastasis in the absence of telomerase activity in oncogene induced mammary cancer.
  Bojovic B, Crowe DL. Bojovic B, et al. Mol Carcinog. 2013 Feb;52(2):103-17. doi: 10.1002/mc.21834. Epub 2011 Nov 15. Mol Carcinog. 2013. PMID: 22086874
• A critical role for telomeres in suppressing and facilitating carcinogenesis.
  Artandi SE, DePinho RA. Artandi SE, et al. Curr Opin Genet Dev. 2000 Feb;10(1):39-46. doi: 10.1016/s0959-437x(99)00047-7. Curr Opin Genet Dev. 2000. PMID: 10679392 Review.
• Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics--current status and future prospects.
  Kelland LR. Kelland LR. Eur J Cancer. 2005 May;41(7):971-9. doi: 10.1016/j.ejca.2004.11.024. Eur J Cancer. 2005. PMID: 15862745 Review.

Cited by

• The fetal programming of telomere biology hypothesis: an update.
  Entringer S, de Punder K, Buss C, Wadhwa PD. Entringer S, et al. Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):20170151. doi: 10.1098/rstb.2017.0151. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29335381 Free PMC article. Review.
• Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
  Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S. Laud PR, et al. Genes Dev. 2005 Nov 1;19(21):2560-70. doi: 10.1101/gad.1321305. Genes Dev. 2005. PMID: 16264192 Free PMC article.
• Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice.
  Canela A, Martín-Caballero J, Flores JM, Blasco MA. Canela A, et al. Mol Cell Biol. 2004 May;24(10):4275-93. doi: 10.1128/MCB.24.10.4275-4293.2004. Mol Cell Biol. 2004. PMID: 15121848 Free PMC article.
• The telomerase cycle: normal and pathological aspects.
  Brunori M, Luciano P, Gilson E, Géli V. Brunori M, et al. J Mol Med (Berl). 2005 Apr;83(4):244-57. doi: 10.1007/s00109-004-0616-2. Epub 2005 Jan 4. J Mol Med (Berl). 2005. PMID: 15630594 Review.
• A defect of amphiregulin release predicted longer survival independently of YAP expression in patients with pleural mesothelioma in the IFCT-0701 MAPS phase 3 trial.
  Maille E, Levallet J, Dubois F, Antoine M, Danel C, Creveuil C, Mazieres J, Margery J, Greillier L, Gounant V, Moro-Sibilot D, Molinier O, Léna H, Monnet I, Bergot E, Langlais A, Morin F, Scherpereel A, Zalcman G, Levallet G. Maille E, et al. Int J Cancer. 2022 Jun 1;150(11):1889-1904. doi: 10.1002/ijc.33997. Epub 2022 Mar 16. Int J Cancer. 2022. PMID: 35262190 Free PMC article. Clinical Trial.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)