Plasticity and reprogramming of differentiated cells in amphibian regeneration - PubMed (original) (raw)
Review
doi: 10.1038/nrm881.
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- PMID: 12154368
- DOI: 10.1038/nrm881
Review
Plasticity and reprogramming of differentiated cells in amphibian regeneration
Jeremy P Brockes et al. Nat Rev Mol Cell Biol. 2002 Aug.
Abstract
Adult urodele amphibians, such as the newt, can regenerate their limbs and various other structures. This is the result of the plasticity and reprogramming of residual differentiated cells, rather than the existence of a 'reserve-cell' mechanism. The recent demonstrations of plasticity in mouse myotubes should facilitate comparative studies of the pathways that underlie the regenerative response, as well as proposing new approaches to promote mammalian regeneration.
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