Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility - PubMed (original) (raw)
. 2001 Nov 7:(21):2159-69.
Affiliations
- PMID: 12240095
Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility
G W Cave et al. Chem Commun (Camb). 2001.
Abstract
A paradigm shift away from using solvents in organic synthesis as solventless reactions can lead to improved outcomes, and more benign synthetic procedures, in for example aldol condensation reactions, sequential aldol and Michael addition reactions en route to Kröhnke type pyridines, reactions leading to 3-carboxycoumarins, benzylidenes, 4-aryl-1,4-dihydropyridines and 2-aryl-1,2,3,4-tetrahydroquinazolines, and oligomerisation reactions for the synthesis of cavitands; kinetic considerations for the reaction of two solids can only be explained if a eutectic melt is formed during the reaction.
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