Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer - PubMed (original) (raw)
. 2002 Nov 1;62(21):6011-4.
Affiliations
- PMID: 12414620
Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer
Vicki L J Whitehall et al. Cancer Res. 2002.
Erratum in
- Cancer Res 2002 Dec 1;62(23):7132
Abstract
Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRCs into three groups: MINT++ (>2), MINT+ (1-2), and MINT- (0 markers methylated). The MSS/MSI-L/MINT++ group was indistinguishable from the MSI-H/MINT++ group with respect to methylation of p16(INK4a), p14(ARF), and RIZ1, and multiple morphological features. The only significant difference between MSI-H and non-MSI-H MINT++ cancers was the higher frequency of K-ras mutation (P < 0.004) and lower frequency of hMLH1 methylation (P < 0.001) in the latter. These data demonstrate that the separation of CRC into two nonoverlapping groups (MSI-H versus MSS/MSI-L) is a misleading oversimplification.
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