Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies - PubMed (original) (raw)

Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies

K B Pedersen et al. Br J Cancer. 2002.

Abstract

In 66 breast cancer biopsies, the expression of the Ca(2+)-binding protein S100A4, E-cadherin, alpha- and beta-catenin was examined by immunohistochemistry, and the results were related to clinical and pathological parameters. High levels of S100A4 were found to significantly correlate with histological grade (P=0.030) and loss of oestrogen receptor (P=0.046), but not to the time interval between surgery and development of distant metastasis (P=0.51) or to patient survival (P=0.89). Loss of E-cadherin expression, associated with altered cell-cell adhesion, showed a highly significant association to overall survival (P=0.020) and metastasis-free period (P=0.0052). In multivariate analysis, only lymph node involvement was a more significant predictor of patient demise. No association was found between expression of S100A4 and any single member of the cadherin-catenin complex, but a trend (P=0.053) towards reduced expression of one or several of these proteins and S100A4 immunoreactivity was observed. In conclusion, although our results suggest an association between S100A4 expression and an aggressive tumour phenotype, no relationship to overall survival was found. Deregulation of E-cadherin expression, however, was of high prognostic significance.

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Figures

Figure 1

Figure 1

Top panel: Tumour tissue showing strong immunoreactivity (+++) to the proteins indicated. Note the cytoplasmic staining for S100A4, while the adhesion molecules show a membranous distribution. Lower panel: Tumour tissue showing no (−) immunoreactivity.

Figure 2

Figure 2

Kaplan–Meier survival curves demonstrating the relationship between patient survival and protein expression of S100A4 (a) and (b) E-cadherin.

References

    1. AlbertazziECajoneFLeoneBENaguibRNLakshmiMSSherbetGV1998Expression of metastasis-associated genes h-mts1 (S100A4) and nm23 in carcinoma of breast is related to disease progression DNA Cell Biol 17335342 - PubMed
    1. BarracloughR1998Calcium-binding protein S100A4 in health and disease Biochim Biophys Acta 1448190199 - PubMed
    1. BehrensJ1999Cadherins and catenins: role in signal transduction and tumor progression Cancer Metastasis Rev 181530 - PubMed
    1. BehrensJvon KriesJPKuhlMBrunhLWedlichDGrosschedlRBirchmeierW1996Functional interaction of beta-catenin with the transcription factor LEF-1 Nature 382638642 - PubMed
    1. BjornlandKWinbergJOOdegaardOTHovigELoennechenTAasenAOFodstadOMælandsmoGM1999S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme Cancer Res 5947024708 - PubMed

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