Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background - PubMed (original) (raw)

Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background

Milena Hasan et al. Eur J Immunol. 2002 Dec.

Free article

Abstract

The expression of the preB cell receptor (preBCR), composed of the mu chain, surrogate light chains and the Igalpha /Igbeta signal transduction unit, permits further differentiation of Bcell precursors. C57BL/6 mice homozygous for an inactivating mutation of the membrane exon of the mu chain gene (C57BL/6muMT/muMT)) cannot form a preBCR and are, consequently, devoid of mature B lymphocytes. Here we present evidence that the block of B cell development by the muMT mutation is incomplete in BALB/c mice. Unlike C57BL/6muMT/muMT), BALB/cmuMT/muMT) mice generate small numbers of mature B cells, accumulate plasma cells and produce high levels of all immunoglobulin isotypes, except IgM. The observed phenomenon seems to be controlled by a single genetic locus that is not linked to IgH.

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Incomplete block of B cell development and immunoglobulin production in mice carrying the muMT mutation on the BALB/c background - PubMed (original) (raw)