Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes - PubMed (original) (raw)

doi: 10.1038/ni872. Epub 2002 Nov 25.

Affiliations

PMID: 12447360
DOI: 10.1038/ni872

Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes

Mara Messi et al. Nat Immunol. 2003 Jan.

Abstract

CD4+ T cell priming under T helper type I (T(H)1) or T(H)2 conditions gives rise to polarized cytokine gene expression. We found that in these conditions human naive T cells acquired stable histone hyperacetylation at either the Ifng or Il4 promoter. Effector memory T cells showed polarized cytokine gene acetylation patterns in vivo, whereas central memory T cells had hypoacetylated cytokine genes but acquired polarized acetylation and expression after appropriate stimulation. However, hypoacetylation of the nonexpressed cytokine gene did not lead to irreversible silencing because most T(H)1 and T(H)2 cells acetylated and expressed the alternative gene when stimulated under opposite T(H) conditions. Such cytokine flexibility was absent in a subset of T(H)2 cells that failed to up-regulate T-bet and to express interferon-gamma when stimulated under T(H)1 conditions. Thus, most human CD4+ T cells retain both memory and flexibility of cytokine gene expression.

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Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes - PubMed (original) (raw)