The role of p53 in determining sensitivity to radiotherapy - PubMed (original) (raw)
Review
doi: 10.1038/nrc992.
Affiliations
- PMID: 12563311
- DOI: 10.1038/nrc992
Review
The role of p53 in determining sensitivity to radiotherapy
Andrei V Gudkov et al. Nat Rev Cancer. 2003 Feb.
Abstract
Ionizing radiation (IR) has proven to be a powerful medical treatment in the fight against cancer. Rational and effective use of its killing power depends on understanding IR-mediated responses at the molecular, cellular and tissue levels. Tumour cells frequently acquire defects in the molecular regulatory mechanisms of the response to IR, which sensitizes them to radiation therapy. One of the key molecules involved in a cell's response to IR is p53. Understanding these mechanisms indicates new rational approaches to improving cancer treatment by IR.
Similar articles
- P53 and radiation responses.
Fei P, El-Deiry WS. Fei P, et al. Oncogene. 2003 Sep 1;22(37):5774-83. doi: 10.1038/sj.onc.1206677. Oncogene. 2003. PMID: 12947385 Review. - Functional p53 increases prostate cancer cell survival after exposure to fractionated doses of ionizing radiation.
Scott SL, Earle JD, Gumerlock PH. Scott SL, et al. Cancer Res. 2003 Nov 1;63(21):7190-6. Cancer Res. 2003. PMID: 14612513 - Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?
Coates PJ, Lorimore SA, Lindsay KJ, Wright EG. Coates PJ, et al. J Pathol. 2003 Nov;201(3):377-88. doi: 10.1002/path.1456. J Pathol. 2003. PMID: 14595749 - JNK/p53 mediated cell death response in K562 exposed to etoposide-ionizing radiation combined treatment.
Sabatini N, Di Giacomo V, Rapino M, Rana R, Garaci G, Cataldi A. Sabatini N, et al. J Cell Biochem. 2005 Jun 1;95(3):611-9. doi: 10.1002/jcb.20392. J Cell Biochem. 2005. PMID: 15832344 - Targeting p53 for enhanced radio- and chemo-sensitivity.
Lu C, El-Deiry WS. Lu C, et al. Apoptosis. 2009 Apr;14(4):597-606. doi: 10.1007/s10495-009-0330-1. Apoptosis. 2009. PMID: 19259822 Review.
Cited by
- Dynamic role of CUL4B in radiation-induced intestinal injury-regeneration.
Guo B, Huo X, Xie X, Zhang X, Lian J, Zhang X, Gong Y, Dou H, Fan Y, Mao Y, Wang J, Hu H. Guo B, et al. Sci Rep. 2024 Apr 30;14(1):9906. doi: 10.1038/s41598-024-60704-4. Sci Rep. 2024. PMID: 38689033 Free PMC article. - Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy.
Song B, Yang P, Zhang S. Song B, et al. Cancer Commun (Lond). 2024 Mar;44(3):297-360. doi: 10.1002/cac2.12520. Epub 2024 Feb 4. Cancer Commun (Lond). 2024. PMID: 38311377 Free PMC article. Review. - Translating p53-based therapies for cancer into the clinic.
Peuget S, Zhou X, Selivanova G. Peuget S, et al. Nat Rev Cancer. 2024 Mar;24(3):192-215. doi: 10.1038/s41568-023-00658-3. Epub 2024 Jan 29. Nat Rev Cancer. 2024. PMID: 38287107 Review. - Targeted Radium Alpha Therapy in the Era of Nanomedicine: In Vivo Results.
Trencsényi G, Csikos C, Képes Z. Trencsényi G, et al. Int J Mol Sci. 2024 Jan 4;25(1):664. doi: 10.3390/ijms25010664. Int J Mol Sci. 2024. PMID: 38203834 Free PMC article. Review. - Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies.
Lu Q, Liang Y, Tian S, Jin J, Zhao Y, Fan H. Lu Q, et al. Toxics. 2023 Dec 10;11(12):1011. doi: 10.3390/toxics11121011. Toxics. 2023. PMID: 38133412 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous