High levels of Y-chromosome differentiation among native Siberian populations and the genetic signature of a boreal hunter-gatherer way of life - PubMed (original) (raw)

Review

High levels of Y-chromosome differentiation among native Siberian populations and the genetic signature of a boreal hunter-gatherer way of life

Tatiana M Karafet et al. Hum Biol. 2002 Dec.

Abstract

We examined genetic variation on the nonrecombining portion of the Y chromosome (NRY) to investigate the paternal population structure of indigenous Siberian groups and to reconstruct the historical events leading to the peopling of Siberia. A set of 62 biallelic markers on the NRY were genotyped in 1432 males representing 18 Siberian populations, as well as nine populations from Central and East Asia and one from European Russia. A subset of these markers defines the 18 major NRY haplogroups (A-R) recently described by the Y Chromosome Consortium (YCC 2002). While only four of these 18 major NRY haplogroups accounted for -95% of Siberian Y-chromosome variation, native Siberian populations differed greatly in their haplogroup composition and exhibited the highest phiST value for any region of the world. When we divided our Siberian sample into four geographic regions versus five major linguistic groupings, analyses of molecular variance (AMOVA) indicated higher phiST and phiCT values for linguistic groups than for geographic groups. Mantel tests also supported the existence of NRY genetic patterns that were correlated with language, indicating that language affiliation might be a better predictor of the genetic affinity among Siberians than their present geographic position. The combined results, including those from a nested cladistic analysis, underscored the important role of directed dispersals, range expansions, and long-distance colonizations bound by common ethnic and linguistic affiliation in shaping the genetic landscape of Siberia. The Siberian pattern of reduced haplogroup diversity within populations combined with high levels of differentiation among populations may be a general feature characteristic of indigenous groups that have small effective population sizes and that have been isolated for long periods of time.

PubMed Disclaimer

Cited by

Mitochondrial DNA and Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians.
Dulik MC, Zhadanov SI, Osipova LP, Askapuli A, Gau L, Gokcumen O, Rubinstein S, Schurr TG. Dulik MC, et al. Am J Hum Genet. 2012 Feb 10;90(2):229-46. doi: 10.1016/j.ajhg.2011.12.014. Epub 2012 Jan 25. Am J Hum Genet. 2012. PMID: 22281367 Free PMC article.
Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations.
Behar DM, Garrigan D, Kaplan ME, Mobasher Z, Rosengarten D, Karafet TM, Quintana-Murci L, Ostrer H, Skorecki K, Hammer MF. Behar DM, et al. Hum Genet. 2004 Mar;114(4):354-65. doi: 10.1007/s00439-003-1073-7. Epub 2004 Jan 22. Hum Genet. 2004. PMID: 14740294
First molecular screening of deafness in the Altai Republic population.
Posukh O, Pallares-Ruiz N, Tadinova V, Osipova L, Claustres M, Roux AF. Posukh O, et al. BMC Med Genet. 2005 Mar 24;6:12. doi: 10.1186/1471-2350-6-12. BMC Med Genet. 2005. PMID: 15790391 Free PMC article.
The study of human Y chromosome variation through ancient DNA.
Kivisild T. Kivisild T. Hum Genet. 2017 May;136(5):529-546. doi: 10.1007/s00439-017-1773-z. Epub 2017 Mar 4. Hum Genet. 2017. PMID: 28260210 Free PMC article. Review.
The Druze: a population genetic refugium of the Near East.
Shlush LI, Behar DM, Yudkovsky G, Templeton A, Hadid Y, Basis F, Hammer M, Itzkovitz S, Skorecki K. Shlush LI, et al. PLoS One. 2008 May 7;3(5):e2105. doi: 10.1371/journal.pone.0002105. PLoS One. 2008. PMID: 18461126 Free PMC article.

High levels of Y-chromosome differentiation among native Siberian populations and the genetic signature of a boreal hunter-gatherer way of life - PubMed (original) (raw)