ATP synthesis driven by proton transport in F1F0-ATP synthase - PubMed (original) (raw)

Review

. 2003 Jun 12;545(1):61-70.

doi: 10.1016/s0014-5793(03)00394-6.

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Review

ATP synthesis driven by proton transport in F1F0-ATP synthase

Joachim Weber et al. FEBS Lett. 2003.

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Abstract

Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms.

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